58 research outputs found
Surface Activity and Mechanism of Action of Antiarrhythmic Drugs
Get PDFSurface active substances are widely used in medicine, among
them the drugs capable of adsorption in efficient concentrations at
various interface points. The relationship between the pharmacological
action of a ntiarrhythmic drugs and their surface activity and
influence on the lipid-containing interfaces (bimolecular layers of
phosphatidylcholine) have been studied. It has been revealed that
diphisopronyle (diethylaminopropyl ether a-isopropyloxydiphenylacetic
acid, hydrochloride), fubromegane (1-methyl-3-diethylaminopropyl
ether 5-bromofurane-2-carboxylic acid, iodomethylate), methamicile
(~-diethylaminopropyl ether benzyl acid, hydrochloride),
propranolole (l-isopropylamino-3 (oxynaphtyl-1)--propanol-2, hydrochloride),
chinidine (chinidine sulphate), novocainamide (~-diethylaminoethyl-
amid p-aminobenzoic acid, hydrochloride), novocaine
(~ -diethylaminoethyl ether p-aminobenzoic acid, hydrochloride), xylocaine
(N,N-diethylamino-2,6-dimethylacethanilide, hydrochloride),
trimecaine (N,N-diethylamino-2,4,6-trimethylacethanilide, hydrochloride)
possess surface activity. Parallelism between the physiological
action and interfacial activity of antiarrhythmic drugs has
been established. Antiarrhythmics increase the electric conductance
of lecithine bilayers. There exists a symbate dependence between
the effect of drugs on the permeability of a bimolecular lecithin
membrane and . their pharmacological activity. These results are
essential a) for understanding the mode of action of antiarrhythmic
agents and b) discovering new drugs which possess the required
properties
The local reflex component in the cardiac response to raised intrapulmonary pressure and to increased pressure in the vena cava
No full textSurface Activity and Mechanism of Action of Antiarrhythmic Drugs
Get PDFSurface active substances are widely used in medicine, among
them the drugs capable of adsorption in efficient concentrations at
various interface points. The relationship between the pharmacological
action of a ntiarrhythmic drugs and their surface activity and
influence on the lipid-containing interfaces (bimolecular layers of
phosphatidylcholine) have been studied. It has been revealed that
diphisopronyle (diethylaminopropyl ether a-isopropyloxydiphenylacetic
acid, hydrochloride), fubromegane (1-methyl-3-diethylaminopropyl
ether 5-bromofurane-2-carboxylic acid, iodomethylate), methamicile
(~-diethylaminopropyl ether benzyl acid, hydrochloride),
propranolole (l-isopropylamino-3 (oxynaphtyl-1)--propanol-2, hydrochloride),
chinidine (chinidine sulphate), novocainamide (~-diethylaminoethyl-
amid p-aminobenzoic acid, hydrochloride), novocaine
(~ -diethylaminoethyl ether p-aminobenzoic acid, hydrochloride), xylocaine
(N,N-diethylamino-2,6-dimethylacethanilide, hydrochloride),
trimecaine (N,N-diethylamino-2,4,6-trimethylacethanilide, hydrochloride)
possess surface activity. Parallelism between the physiological
action and interfacial activity of antiarrhythmic drugs has
been established. Antiarrhythmics increase the electric conductance
of lecithine bilayers. There exists a symbate dependence between
the effect of drugs on the permeability of a bimolecular lecithin
membrane and . their pharmacological activity. These results are
essential a) for understanding the mode of action of antiarrhythmic
agents and b) discovering new drugs which possess the required
properties
Changes in the structure of spike trains of cortical neurons produced by prolonged administration of different doses of neuroleptics
No full textEffect of agonists and antagonists of opiate receptors on resistance of animals to hypoxic hypoxia
No full textReflex changes in the intracardial nervous formations encountered in focal experimental myocarditis
No full text
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