4 research outputs found
A Comparison of Methods for Automated Motion Correction of DCE-MRI Perfusion Datasets Evaluated in Terms of Diagnostic Accuracy: A CE-MARC sub-study
Automated mage registration in cardiac myocardial perfusion
is a necessity before quantitative perfusion can be
widely accepted in clinical practice. Increasingly complex
motion correction algorithms are being developed
to deal with cardiac motion. However, the impact of
these improvements has not been evaluated in terms of
the final clinical diagnosis. Advanced motion correction
methods are associated with increased computational
overhead and the potential of introducing subtle registration
errors, which can be hard to detect and quantify.
The aim of this study was to compare the performance
of the various automated correction methods in terms
of their impact on diagnostic accuracy
Automated Registration of Dynamic Contrast Enhanced DCE-MRI Cardiac Perfusion Achieves Comparable Diagnostic Accuracy to Manual Motion Correction: a CE-MARC sub-study
The human interaction required for manual motion
correction/contouring of cardiac perfusion series
remains a significant obstacle to quantitative perfusion
gaining a wider acceptance in clinical practice. The use
of image registration for motion correction in perfusion
data offers a considerable time saving. Numerous registration
methods have been proposed, with evaluation
limited to the image registration accuracy. However, the
important clinical question is how do these methods
affect diagnosis? The aim of this study is to evaluate
perfusion series registration in terms of its affect on the
diagnostic accuracy of myocardial ischaemia
Registration of Coronary MRA to DCE-MRI Myocardial Perfusion Series Improves Diagnostic Accuracy Through the Computation of Patient-Specific Coronary Supply Territories: A CE-MARC Sub-Study
Background: It is generally acknowledged that the 17-segment AHA
model provides a suitable approximation for mapping
the results of X-ray angiography onto myocardial anatomy
in a consistent way in the absence of a more exact
method. In practice, coronary anatomy varies from
patient to patient which is acknowledged as the main
limitation of the AHA model. The aim of this study was
to establish whether the generation of a patient-specific
coronary artery to perfusion segment map improved
diagnosis of myocardial ischaemia
Coronary smooth muscle cell calcium dynamics: Effects of bifurcation angle on atheroprone conditions
© 2018 Frontiers Media S.A.All right reserved. This work investigates the effect of arterial bifurcation angulation on atherosclerosis development through in-silico simulations of coupled cell dynamics. The computational model presented here combines cellular pathways, fluid dynamics, and physiologically-realistic vessel geometries as observed in the human vasculature. The coupled cells model includes endothelial cells (ECs) and smooth muscle cells (SMCs) with ion dynamics, hetero and homotypic coupling, as well as electro-diffusive coupling. Three arterial bifurcation surface models were used in the coupled cells simulations. All three simulations showed propagating waves of Ca2+ in both the SMC and EC layers, following the introduction of a luminal agonist, in this case ATP. Immediately following the introduction of ATP concentration Ca2+ waves propagate from the area of high ATP toward the areas of low ATP concentration, forming complex patterns where waves interact with eachother, collide and fade. These dynamic phenomena are repeated with a series of waves of slower velocity. The underlying motivation of this research was to examine the macro-scale phenomena, given that the characteristic length scales of atherosclerotic plaques are much larger than a single cell. The micro-scale dynamics were modeled on macro-scale arterial bifurcation surfaces containing over one million cells. The results of the simulations presented here suggest that susceptibility to atherosclerosis development depends on the bifurcation angulation. In conjunction with findings reported in the literature, the simulation results demonstrate that arterial bifurcations containing wider angles have a more prominent influence on the coupled cells pathways associated with the development of atherosclerosis, by means of disturbed flow and lower SMC Ca2+ concentrations. The discussion of the results considers the findings of this research within the context of the potential link between information transport through frequency encoding of Ca2+ wave dynamics and development of atheroprone conditions