Effect of solvent composition on DSC exothermic peak of human serum albumin suspended in pyridkne-n-hexane mixtures

Human serum albumin (HSA) immersed in pyridine-n-hexane mixtures was analyzed using differential scanning calorimetry (DSC). State of the solid HSA in organic solvent mixtures is the non-equilibrium state which is seen as the exothermic peak on the DSC curves. The enthalpy change corresponding to this exothermic peak approaches zero when going from pure pyridine to pure n-hexane. Dependence of the enthalpy change on the pyridine concentration is suggestive that the non-equilibrium state of the immersed HSA results from the HSA-pyridine interactions 'frozen' at the lower temperature. Most likely the temperature-initiated exothermic peak observed on the DSC curves reflects the swelling of HSA by pyridine

Effect of solvent composition on DSC exothermic peak of human serum albumin suspended in pyridkne-n-hexane mixtures

Human serum albumin (HSA) immersed in pyridine-n-hexane mixtures was analyzed using differential scanning calorimetry (DSC). State of the solid HSA in organic solvent mixtures is the non-equilibrium state which is seen as the exothermic peak on the DSC curves. The enthalpy change corresponding to this exothermic peak approaches zero when going from pure pyridine to pure n-hexane. Dependence of the enthalpy change on the pyridine concentration is suggestive that the non-equilibrium state of the immersed HSA results from the HSA-pyridine interactions 'frozen' at the lower temperature. Most likely the temperature-initiated exothermic peak observed on the DSC curves reflects the swelling of HSA by pyridine

Effect of solvent composition on DSC exothermic peak of human serum albumin suspended in pyridkne-n-hexane mixtures

Human serum albumin (HSA) immersed in pyridine-n-hexane mixtures was analyzed using differential scanning calorimetry (DSC). State of the solid HSA in organic solvent mixtures is the non-equilibrium state which is seen as the exothermic peak on the DSC curves. The enthalpy change corresponding to this exothermic peak approaches zero when going from pure pyridine to pure n-hexane. Dependence of the enthalpy change on the pyridine concentration is suggestive that the non-equilibrium state of the immersed HSA results from the HSA-pyridine interactions 'frozen' at the lower temperature. Most likely the temperature-initiated exothermic peak observed on the DSC curves reflects the swelling of HSA by pyridine

Effect of solvent composition on DSC exothermic peak of human serum albumin suspended in pyridkne-n-hexane mixtures

Human serum albumin (HSA) immersed in pyridine-n-hexane mixtures was analyzed using differential scanning calorimetry (DSC). State of the solid HSA in organic solvent mixtures is the non-equilibrium state which is seen as the exothermic peak on the DSC curves. The enthalpy change corresponding to this exothermic peak approaches zero when going from pure pyridine to pure n-hexane. Dependence of the enthalpy change on the pyridine concentration is suggestive that the non-equilibrium state of the immersed HSA results from the HSA-pyridine interactions 'frozen' at the lower temperature. Most likely the temperature-initiated exothermic peak observed on the DSC curves reflects the swelling of HSA by pyridine

Charge-Transfer Complexes of Linear Acenes with a New Acceptor Perfluoroanthraquinone. The Interplay of Charge-Transfer and F···F Interactions

© 2019 American Chemical Society. Two charge-transfer bicomponent 1:1 crystals of polycyclic aromatic hydrocarbons (anthracene and tetracene) with a new acceptor molecule (perfluoroanthraquinone) were grown by slow evaporation from solutions in toluene. In both crystals, π-πstacks of alternating donor and acceptor molecules are observed. In the tetracene-perfluoroanthraquinone complex, face-to-face stacking is the prevailing intermolecular interaction, while in the complex of anthracene-perfluoroanthraquinone multiple interactions (stacking, F···H, O···H, F···F) of similar energy are observed, as revealed by the Quantum Theory of Atoms in Molecules method, resulting in the formation of polymorphic modifications, as determined by X-ray single crystal diffraction and differential scanning calorimetry. The charge-transfer degree was estimated to be equal to 0.04 and 0.08 e in anthracene- and tetracene-containing complexes, respectively