2 research outputs found
The prevalence and associated factors of clinical and subclinical rheumatic heart disease among rheumatic heart disease children admitted in HUSM
INTRODUCTION
Rheumatic heart disease or rheumatic carditis remains the leading cause of acquired
heart disease in children worldwide and continues to be an important public health
problem in developing countries. To date, there is no local data regarding the clinical
and subclinical rheumatic heart disease.
OBJECTIVES:
The main objectives of this study is to determine the prevalence of clinical and
subclinical rheumatic heart disease and to study the factors associated with both clinical
and subclinical rheumatic heart disease in children presented to Hospital Universiti
Sains Malaysia.
METHODS:
This study was conducted via retrospective record review of children with rheumatic
heart disease who was referred or admitted to Hospital Universiti Sains Malaysia from
2002 to 2014 who meet all the study criteria.
RESULT
There were 171 newly diagnosed rheumatic heart disease patients included in this study.
The prevalence of clinical rheumatic heart disease and subclinical rheumatic heart
disease were 86.5% and 13.5% respectively. The mean age at diagnosis of rheumatic
heart disease was 10.8 years old and predominantly male with ratio of 1.1 to 1. The
mean age for subclinical rheumatic heart disease was 9 years old and predominantly
female. All patients of rheumatic heart disease involved in this study were Malay.
Majority of the patients of rheumatic heart disease were from rural areas and it
accounted for 60.2%. Patient with rheumatic heart disease mainly have siblings more
than 5 which is 52.6%, as compared to number of siblings less or equal to 5 which
comprised only 47.4%. The low household income group showed high prevalence of
rheumatic heart disease, in which 78.7% of the cases of clinical rheumatic heart disease
and comprised of 56.3% cases of subclinical. The majority of the parents were educated
up to secondary school level, which was comprised of 76.4%. Age was the only
significant factor which influenced subclinical RHD compare to clinical RHD.
CONCLUSION
The prevalence of subclinical rheumatic heart disease in this study was comparable to
other studies. Increasing age was less likely to develop subclinical rheumatic heart
disease compare to clinical RHD
Audit of newborn screening programme for congenital hypothyroidism
Congenital hypothyroidism screening programme in Universiti Sains Malaysia (USM) was started since 2004 using cord blood TSH. An audit of the screening programme for a period of 24 months was done for the year 2010 and 2011. A total of 12928 newborn babies were screened with coverage of 100%. Two cases were confirmed to have primary congenital hypothyroidism. The mean recall rate was 2.31% and the mean sample rejection rate was 1.59%. The subject response for the repeat test was 63% for the year 2010 and 78% for the year 2011. Continuous surveillance is important to ensure the National Quality Assurance (QA) were met