Physicochemical characterization and drug release properties of Eudragit® E PO/Eudragit® L 100-55 interpolyelectrolyte complexes

The formation of interpolyelectrolyte complexes (IPEC) between Eudragit® E PO (EE) and Eudragit® L 100-55 (EL) was investigated, using turbidimetry, apparent viscosity measurements, elementary analysis and MT-DSC. The structure of the synthesized IPEC was investigated using FT-IR spectroscopy. The binding ratio of a unit molecule of EL with EE was found to be approximately 1:1 at pH 5.5. Based on the results of elementary analysis and FT-IR, the binding ratio of each component in the solid complexes was very close to that observed in turbidity and apparent viscosity measurements and indicate that the synthesized products can be considered as IPEC. As a result of electrostatic interaction between the polymer chains, the glass transition temperature of the IPEC increased significantly. Due to the structure of the IPEC, two maxima were observed in the swelling behavior as a function of pH. The release of the model drug ibuprofen (IBF) was significantly retarded from tablets made up of the IPEC as compared with individual copolymers, its physical mixture and Eudragit® RL PO (RL), RS PO (RS). © 2005 Elsevier B.V. All rights reserved

ETALON-1,-2 center of mass correction and array reflectivity

Center of mass correction to be applied to measured ranges to the ETALON 1 and 2 satellites is considered. Numerical values of the correction and reflectivity from the retroreflector array are computed. The variations of these values with satellite orientation are investigated

"Doubled" generalized Landau-Lifshiz hierarchies and special quasigraded Lie algebras

Using special quasigraded Lie algebras we obtain new hierarchies of integrable nonlinear vector equations admitting zero-curvature representations. Among them the most interesting is extension of the generalized Landau-Lifshitz hierarchy which we call "doubled" generalized Landau-Lifshiz hierarchy. This hierarchy can be also interpreted as an anisotropic vector generalization of "modified" Sine-Gordon hierarchy or as a very special vector generalization of so(3) anisotropic chiral field hierarchy.Comment: 16 pages, no figures, submitted to Journal of Physics

Sistema renovador de reproducción de capacidad profesional como condición efectiva de gestión regional

The article studies the orientation of professional potential reproduction to ensure the effectiveness of regional management, discloses the mechanisms for management professional potential transformation into the indicators of its effectiveness and efficiency. They provided the data of the sociological study “Professional potential reproduction system development among regional management personnel”. The result of the study in this direction was the developed cumulative technology for computer assessment of the competence potential among regional management employees, which includes three blocks: assessment unit, planning unit, and control (correction) unit.El artículo estudia la orientación de la reproducción potencial profesional para garantizar la efectividad de la gestión regional, revela los mecanismos para la transformación del potencial profesional de gestión en los indicadores de su eficacia y eficiencia. Proporcionaron los datos del estudio sociológico “Desarrollo potencial profesional del sistema de reproducción entre el personal de gestión regional”. El resultado del estudio en esta dirección fue la tecnología acumulada desarrollada para la evaluación informática del potencial de competencia entre los empleados de gestión regional, que incluye tres bloques: unidad de evaluación, unidad de planificación y unidad de control (corrección)

STATE GOVERNANCE OF SOCIO-DEMOGRAPHIC PROCESSES IN AGING SOCIETY

Purpose of the study: The main approach of the research is a combination of methodological and applied aspects, including the development of public policy directions aimed at prolonging the active longevity of the Russian population. Methodology: The research used a statistical analysis of the processing of official statistics of Rosstat, data of international organizations - the United Nations (Population Division), the World Bank, the World Health Organization (WHO); analytical - analysis of regulatory legal acts of Russian and international law in the field of regulation. Results: The authors analyze global and Russian trends in an aging society. The influence of the demographic aging of the population on the socio-economic development of the state is revealed. The main directions of the state policy in relation to the aging problems of the population are determined, and the world experience of solving the indicated problems is studied. Applications of this study: This research can be used for the universities, teachers, and students. Novelty/Originality of this study: In this research, the model of state governance of socio-demographic processes in an aging society is presented in a comprehensive and complete manner

Dynamics of risk degree of innovation-driven growth at higher education institutions

In this article, the analysis of dynamics of risk degree of innovation-driven growth at higher education institutions is discussed. The survey has been employed in this paper and the data analyzed by SPSS software. Results revealed that the resulting risks are regularly encountered in a modern Russian higher educational institution: inability to provide necessary financial support for educational activities; inability to provide required modern material and technical basis; challenges and failures in collaboration with enterprises for organizing practical training for students and the absence of practical training programs at the university. It is also indicated that the risk event might lead to different results: negative, positive, or nul

Transformation approach to implementation of transparency of the Russian supreme audit institution activity

A financial system is generally considered a "circulatory system" of the state, which is essential for its existence. A key role in this system belongs to public funds. That is why issues of improving efficient state audit are becoming extremely important nowaday

DIAGNOSTICS OF PROBLEMS OF REPRODUCTION OF PROFESSIONAL POTENTIAL OF THE STATE AND MUNICIPAL MANAGEMENT AS A PRECONDITION OF ITS SYSTEM RENOVATION

Purpose of the study: This article deals with the renovation system of reproduction of professional potential and provides a definition of this concept. Methodology: The study uses the methods of dialectical contradiction, the ascent from the abstract to the concrete, structural-functional and comparative analysis, theoretical modeling and generalization. Primary sociological information is collected through a questionnaire survey, document analysis, free interview, and observation. Methods of grouping and classification of empirical data, qualitative analysis of factors are also used. Results: the renovation system of reproduction of the professional potential of a state municipal government involves the diagnosis of its problems with the aim of determining the ways of their resolution. The conducted diagnostics identified six groups of actual problems, namely lack of professionalism, the disintegration of indicators of individual and institutional efficiency, the imperfect system of training and advanced training of managerial personnel, the weak motivation of their professional development, inefficient use of professional potential, and passive personnel policy Applications of this study: This research can be used for the universities, teachers, and students. Novelty/Originality of this study: In this research, the model of Diagnostics of Problems of Reproduction of Professional Potential of the State and Municipal Management as a Precondition of Its System Renovation is presented in a comprehensive and complete manner

Life without water: Cryptobiosis of invertebrates as a model for next generation techmology of biomaterials preservation

To date, advances in the field of tissue engineering, cell transplantation and genetic engineering have made the biological materials of different origin an important therapeutic tool in clinical medicine. Currently, cells preservation is achieved by freezing at -80°? or in liquid nitrogen. Cryopreservation technology is expensive and has considerable limits during transportation. Preservation of viable biological material in dry state under ambient temperature is considered as attractive, but yet fully achieved alternative. There are organisms which are able to survive complete water loss. Understanding of mechanisms underlying dehydration tolerance will allow the development of dry preservation technology for molecules, cells and organs, and further use of these methods in medicine, pharmacology and biotechnology

Kinetics of exciton photoluminescence in type-II semiconductor superlattices

The exciton decay rate at a rough interface in type-II semiconductor superlattices is investigated. It is shown that the possibility of recombination of indirect excitons at a plane interface essentially affects kinetics of the exciton photoluminescence at a rough interface. This happens because of strong correlation between the exciton recombination at the plane interface and at the roughness. Expressions that relate the parameters of the luminescence kinetics with statistical characteristics of the rough interface are obtained. The mean height and length of roughnesses in GaAs/AlAs superlattices are estimated from the experimental data.Comment: 3 PostScript figure