COVID-19 and the effect of its infodemic on people’s wellbeing

In this research, it was used to look at social media behaviour during the pandemic and how it might have affected well-being. The WHO-5 Well-Being Index (WHO-5) score was used to do this. COVID-19-related material was sought for and disseminated through social media by those who participated in the study. This research shows how social media might affect people's well-being during this epidemic and other crisis in the future. 73 percent of the 993 participants were women, 91 percent were university graduates, and 50 percent worked in diverse occupations, with 20 percent working in health care. Participants said they got COVID-19-related news mostly via social media and messaging apps, with WhatsApp being the most popular. After authentication, the majority of participants said they shared information. Throughout the coronavirus pandemic, this research offers insight into the usage of Social Media and its influence on well-being. During catastrophes and disasters, social media behaviours may have an influence on public safety. There is also a need for global and local health authorities to better prepare for future challenges by developing policies and actions that address these difficulties. Social media activities may directly affect one's mental health, but more research is required before conclusions can be drawn

Supramolecular Interactions Involved in the Solid State Structure of N,N\u27-[bis(pyridin-2-yl)formylidene]ethane-1,2-diamine

The structure of the symmetrical Schiff base, N,N\u27-[bis(pyridin-2-yl)formylidene]ethane-1,2-diamine (bpfd) has been characterized by single crystal X-ray diffraction. The non-covalent supramolecular chemistry involved in the crystal structure of this ligand has been carefully investigated. The structure adopted different motifs of nitrogen-hydrogen interactions that led to the formation of centrosymmetric dimers. In addition, edge-edge and face-face nitrogen-nitrogen interactions were ob-served and reported. The Schiff base (bpfd) ligand crystallizes in a monoclinic space group C12/c1 with a = 19.128(2) Å; b = 5.8776(6) Å; c = 13.1403(15) Å; α = 90o; β = 121.970o(4); γ = 90o and z = 4. This structure is an example of compounds with many symmetry-independent molecules in the asymmetric unit cell (Z > 2)

Effect of Pr3+ doping on structural, electrical, and optical properties of BaTi0.925(Yb0.5Nb0.5)0.075O3 ceramics

cited By 5International audienceThe effect of Pr3+ addition on structural, electrical, and optical properties of Ba1-xPr2x/3Ti0.925(Yb0.5Nb0.5)0.075O3 (0.3% ≤ x ≤ 1%) ceramics was investigated. X-ray studies have allowed the identification of a continuous solid solution with P4mm-tetragonal symmetry of all prepared samples. Incorporation of Pr3+ was found to improve ferroelectric and piezoelectric properties with an optimum at the critical concentration of 0.005. Photoluminescence properties revealed that the introduction of Pr3+ ions gives rise to the green and red photoemissions and permitted to shed more light on the created structural disorder and shallow defects. This effect was confirmed by Raman spectroscopy investigation. The presence of Pr element in such materials may have significant technological promise in novel multifunctional devices. © 2016 Elsevier B.V

Significance of AZD1152 as a potential treatment against Aurora B overexpression in acute promyelocytic leukemia

Aurora B kinase as a chromosomal passenger protein plays multiple roles in regulating mitosis and cytokinesis. The function of Aurora B in leukemic cells has made it an important treatment target. In this study, we explored the expressions of Aurora (A, B, and C) kinases in newly diagnosed acute promyelocytic leukemia (APL) patients. In addition, we investigated the effects of AZD1152 as a specific inhibitor of Aurora B on cell survival, DNA synthesis, nuclear morphology, apoptosis induction, cell cycle distribution, and gene expression in an APL-derived NB4 cell line. Our results showed that Aurora B was overexpressed in 88 of APL patients. AZD1152 treatment of NB4 cells led to viability reduction and G2/M arrest followed by an increase in cell size and polyploidy induction. These giant cells showed morphological evidence of mitotic catastrophe. AZD1152 treatment induced activation of G2/M checkpoint which in turn led to transient G2/M arrest in a p21-independent manner. Lack of functional p53 in NB4 cells might provide an opportunity to escape from G2/M block and to endure repeated rounds of replication and polyploidy. Treated cells were probably eliminated via p73-mediated overexpression of BAX, PUMA, and APAF1 and downregulation of survivin and MCL-1. In summary, AZD1152 treatment led to endomitosis and polyploidy in TP53-mutated NB4 cells. These giant polyploid cells might undergo mitotic catastrophe and p73-mediated apoptosis. It seems that induction of polyploidy via AZD1152 could be a novel form of anti-cancer therapy for APL that may be clinically accessible in the near future. © 2016, Springer-Verlag Berlin Heidelberg