A mini review on food preservatives

Food additives are not recently discovered, humans used food additives from ancient times.These food additives enhance the color and taste of food but also, kill harmful pathogens andkeep food safe for a long time. Ancient people used salting, smoking, jugging and many moretechniques to preserve food but in modern times, lifestyles changed, and people used advancedtechniques like ultra-sonication, vacuum packing, electro plasmolysis, bio preservation,nanotechnology, etc. There are many natural compounds extracted from plants like caffeine,anthocyanin, turmeric, saffron used as food additives. Similarly, many synthetic additives canbe used in food for example ampicillin, benzoic acid, tetrazine and many more. These syntheticadditives are more dangerous as compared to natural additives; therefore, many additives arebanned in the world. These additives are given E codes (European union numbers) and INS(International numbering system of food), but E code is used more commonly and labelled onall food items like chips, biscuit, pharmaceutics, cosmetics etc. In this review, we summarizesome traditional and modern food preservation techniques and give some most commonly usedfood additives with E codes

Physiochemical Analysis of River Sutlej, Sindh and the Arabian Sea to Evaluate the Water Quality

Globally, water pollution is caused primarily by growing populations, urbanization, and modern agricultural techniques. In this study, freshwater samples were collected from Satluj river, Sindh river, and Arabian sea to assess water quality. A variety of physicochemical parameters were measured in these samples, including pH (7.5 to 8.4), color (variable), odor, turbidity (7 NTU to 18 NTU), taste (salty/bitter), total dissolved solids (182 mg/L to 34768 mg/L), total soluble solids (52 mg/L to 1244 mg/L), EC (109 μS/cm to 51488 μS/cm), total hardness/Ca+2+Mg+2 (25 mg/L to 125 mg/L), total alkalinity or CO3-2, HCO3- (80 mg/L to 172 mg/L), exchangeable ions like Cl- (27 mg/L to 19742 mg/L), F- (0.3 mg/L to 1.29 mg/L), SO4-2 (30 mg/L to 2974 mg/L), PO4-3 (8 mg/L to 35 mg/L), NO2-2 (18 mg/L to 43 mg/L), Mn+2 (0.0002 mg/L to 0.63 mg/L), Cu (0.0005 mg/L to 0.08 mg/L), Cd+2 (0.0005 mg/L to 0.88 mg/L), Cr+3 (0.003 mg/L to 0.32 mg/L), Zn+2 (0.001 mg/L to 2.72 mg/L), Fe+2 (0.01 mg/L to 0.9 mg/L), Ni+2 (0.002 mg/L to 0.23 mg/L), Na+ (15 mg/L to 10157 mg/L), K+ (4.4 mg/L to 379 mg/L), Ca+2 (20 mg/L to 380 mg/L), Mg+2 (5.4 mg/L to 1584 mg/L) tested by standard methods reported in Association of Official Analytical Chemists (AOAC) with little modifications. Most of the parameters studied in these water samples were beyond the National Environment Quality Standard of drinking water guidelines for seawater, but within acceptable limits for rivers. Consequently, these trends made seawater unfit for the survival of aquatic plants and marine life as well as for the people who use river water for domestic and agricultural purposes

Exploring the Synthetic Chemistry of Phenyl-3-(5-aryl-2-furyl)- 2-propen-1-ones as Urease Inhibitors: Mechanistic Approach through Urease Inhibition, Molecular Docking and Structure–Activity Relationship

Furan chalcone scaffolds belong to the most privileged and promising oxygen-containing heterocyclic class of compounds, which have a wide spectrum of therapeutic applications in the field of pharmaceutics, pharmacology, and medicinal chemistry. This research described the synthesis of a series of twelve novel and seven reported furan chalcone (conventional synthetic approach) analogues 4a–s through the application of microwave-assisted synthetic methodology and evaluated for therapeutic inhibition potential against bacterial urease enzyme. In the first step, a series of nineteen substituted 5-aryl-2-furan-2-carbaldehyde derivatives 3a–s were achieved in moderate to good yields (40–70%). These substituted 5-aryl-2-furan-2-carbaldehyde derivatives 3a–s were condensed with acetophenone via Claisen–Schmidt condensation to furnish 19 substituted furan chalcone scaffolds 4a–s in excellent yields (85–92%) in microwave-assisted synthetic approach, while in conventional methodology, these furan chalcone 4a–s were furnished in good yield (65–90%). Furan chalcone structural motifs 4a–s were characterized through elemental analysis and spectroscopic techniques. These nineteen (19)-afforded furan chalcones 4a–s were screened for urease inhibitory chemotherapeutic efficacy and most of the furan chalcones displayed promising urease inhibition activity. The most active urease inhibitors were 1-phenyl-3-[5-(2′,5′-dichlorophenyl)-2-furyl]-2–propen-1-one 4h with an IC50 value of 16.13 ± 2.45 μM, and 1-phenyl- 3-[5-(2′-chlorophenyl)-2-furyl] -2-propen-1-one 4s with an IC50 value of 18.75 ± 0.85 μM in comparison with reference drug thiourea (IC50 = 21.25 ± 0.15 μM). These furan chalcone derivatives 4h and 4s are more efficient urease inhibitors than reference drug thiourea. Structure–activity relationship (SAR) revealed that the 2,5-dichloro 4h and 2-chloro 4s moiety containing furan chalcone derivatives may be considered as potential lead reagents for urease inhibition. The in silico molecular docking study results are in agreement with the experimental biological findings. The results of this study may be helpful in the future drug discovery and designing of novel efficient urease inhibitory agents from this biologically active class of furan chalcones