Serous Pigment Epithelium Detachment Associated with Age-Related Macular Degeneration: A Possible Treatment Approach

To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous Pigment Epithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this study has been performed. Seventeen patients (19 eyes) with serous PED associated with AMD were observed. All patients received 0.1ml (4mg) of intravitreal TA. The mean follow-up period was 18 months. Re-attachment of serous PED was observed in 37% of cases to the end of follow-up. In other cases, the height and length of serous PED significantly decreased. Visual acuity remained stable in all cases. No evidence of RPE tear or CNV development were noted. Before TA administration, intraocular pressure (IOP) was 20.18 ± 2.58 mmHg however, after intravitreal TA, IOP increased gradually and reached its maximum of all period of observation (23.25±1.85mmHg) six months after injection (P=0.031). In 7 (37%) of the cases, progression to cataract was observed after treatment. After surgery, the visual acuity in all cases increased by 0.2 to 0.5. As a conclusion, intravitreal TA decreases of both the height and length of serous PED associated with AMD after 18 months follow-up in most cases. The presented data provides support for the hypothesis regarding the possibility of monotherapy of serous PED with intravitreal TA

Heat exchange in the human eye: a review

Thermal homeostasis is required in order to ensure that the normal function of the human body is maintained under various environmental conditions. Various pathological processes impacting metabolism in tissues and organs (e.g., the human eye) are accompanied by changes in relative internal heat balance. Although numerous relevant studies have been conducted, heat exchange processes in the human eye have not been yet sufficiently investigated. Further research on the features of heat exchange in the eye is required not only to improve our knowledge in the field of physiology of the eye, but also to use the data obtained for developing novel advanced techniques for eye disease diagnosis and treatment

Serous Pigment Epithelium Detachment Associated with Age-Related Macular Degeneration: A Possible Treatment Approach

oai:www.mehdijournal.com:article/50To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous Pigment Epithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this study has been performed. Seventeen patients (19 eyes) with serous PED associated with AMD were observed. All patients received 0.1ml (4mg) of intravitreal TA. The mean follow-up period was 18 months. Re-attachment of serous PED was observed in 37% of cases to the end of follow-up. In other cases, the height and length of serous PED significantly decreased. Visual acuity remained stable in all cases. No evidence of RPE tear or CNV development were noted. Before TA administration, intraocular pressure (IOP) was 20.18 ± 2.58 mmHg however, after intravitreal TA, IOP increased gradually and reached its maximum of all period of observation (23.25±1.85mmHg) six months after injection (P=0.031). In 7 (37%) of the cases, progression to cataract was observed after treatment. After surgery, the visual acuity in all cases increased by 0.2 to 0.5. As a conclusion, intravitreal TA decreases of both the height and length of serous PED associated with AMD after 18 months follow-up in most cases. The presented data provides support for the hypothesis regarding the possibility of monotherapy of serous PED with intravitreal TA

First measurement of neutrino oscillation parameters using neutrinos and antineutrinos by NOvA

The NOvA experiment has seen a 4.4σ signal of ν̄e appearance in a 2 GeV ν̄μ beam at a distance of 810 km. Using 12.33×1020 protons on target delivered to the Fermilab NuMI neutrino beamline, the experiment recorded 27 ν̄μ→ν̄e candidates with a background of 10.3 and 102 ν̄μ→ν̄μ candidates. This new antineutrino data are combined with neutrino data to measure the parameters |Δm322|=2.48-0.06+0.11×10-3 eV2/c4 and sin2θ23 in the ranges from (0.53-0.60) and (0.45-0.48) in the normal neutrino mass hierarchy. The data exclude most values near δCP=π/2 for the inverted mass hierarchy by more than 3σ and favor the normal neutrino mass hierarchy by 1.9σ and θ23 values in the upper octant by 1.6σ

Search for multimessenger signals in NOvA coincident with LIGO/Virgo detections

Using the NOvA neutrino detectors, a broad search has been performed for any signal coincident with 28 gravitational wave events detected by the LIGO/Virgo Collaboration between September 2015 and July 2019. For all of these events, NOvA is sensitive to possible arrival of neutrinos and cosmic rays of GeV and higher energies. For five (seven) events in the NOvA Far (Near) Detector, timely public alerts from the LIGO/Virgo Collaboration allowed recording of MeV-scale events. No signal candidates were found

Search for multimessenger signals in NOvA coincident with LIGO/Virgo detections

Using the NOvA neutrino detectors, a broad search has been performed for any signal coincident with 28 gravitational wave events detected by the LIGO/Virgo Collaboration between September 2015 and July 2019. For all of these events, NOvA is sensitive to possible arrival of neutrinos and cosmic rays of GeV and higher energies. For five (seven) events in the NOvA Far (Near) Detector, timely public alerts from the LIGO/Virgo Collaboration allowed recording of MeV-scale events. No signal candidates were found

First measurement of neutrino oscillation parameters using neutrinos and antineutrinos by NOvA

The NOvA experiment has seen a 4.4 σ signal of ¯ ν e appearance in a 2 GeV ¯ ν μ beam at a distance of 810 km. Using 12.33 × 10 20 protons on target delivered to the Fermilab NuMI neutrino beamline, the experiment recorded 27 ¯ ν μ → ¯ ν e candidates with a background of 10.3 and 102 ¯ ν μ → ¯ ν μ candidates. This new antineutrino data are combined with neutrino data to measure the parameters | Δ m 2 32 | = 2.4 8 + 0.11 − 0.06 × 10 − 3     eV 2 / c 4 and sin 2 θ 23 in the ranges from (0.53–0.60) and (0.45–0.48) in the normal neutrino mass hierarchy. The data exclude most values near δ C P = π / 2 for the inverted mass hierarchy by more than 3 σ and favor the normal neutrino mass hierarchy by 1.9 σ and θ 23 values in the upper octant by 1.6 σ

Seasonal Variation of Multiple-Muon Cosmic Ray Air Showers Observed in the NOvA Detector on the Surface

We report the rate of cosmic ray air showers with multiplicities exceeding 15 muon tracks recorded in the NOvA Far Detector between May 2016 and May 2018. The detector is located on the surface under an overburden of 3.6 meters water equivalent. We observe a seasonal dependence in the rate of multiple-muon showers, which varies in magnitude with multiplicity and zenith angle. During this period, the effective atmospheric temperature and surface pressure ranged between 210 K to 230 K and 940mbar to 990mbar, respectively; the shower rates are anti-correlated with the variation in the effective temperature. The variations are about 30% larger for the highest multiplicities than the lowest multiplicities and 20% larger for showers near the horizon than vertical showers