In vivo biocompatibility assessment of (PTFE–PVDF–PP) terpolymer-based membrane with potential application for glaucoma treatment

The aim of the work was to evaluate the in vivo biological behaviour of polymeric membrane materials for glaucoma implants. The base material was biostable synthetic terpolymer (PTFE–PVDF–PP) with proved biocompability (PN-EN ISO 10993). The samples manufactured in the form a membrane were subjected to chemical and physical treatment to create an open pore system within the polymer matrix. As a porogenic phase biodegradable natrium alginate in a fibrous form was employed. The non-perforating deep sclerectomy technique was performed in a rabbit model. The clinical observations were made after 14 and 30 days. During the study clinical symptoms of a moderate degree were observed, and histopathological changes were typical for foreign body implantation. At the end stage of the study no significant difference in histopathological assessment was found between control and experimental group. Similarities observed in both groups and relatively mild histopathological changes in the tissue surrounding the implant indicate that the observed symptoms come from a deep scleral trauma caused by surgery, and not by the presence of the implant itself

QURATOR: Innovative technologies for content and data curation

In all domains and sectors, the demand for intelligent systems to support the processing and generation of digital content is rapidly increasing. The availability of vast amounts of content and the pressure to publish new content quickly and in rapid succession requires faster, more efficient and smarter processing and generation methods. With a consortium of ten partners from research and industry and a broad range of expertise in AI, Machine Learning and Language Technologies, the QURATOR project, funded by the German Federal Ministry of Education and Research, develops a sustainable and innovative technology platform that provides services to support knowledge workers in various industries to address the challenges they face when curating digital content. The project’s vision and ambition is to establish an ecosystem for content curation technologies that significantly pushes the current state of the art and transforms its region, the metropolitan area Berlin-Brandenburg, into a global centre of excellence for curation technologies