Oral administration and intralesional injection of hyaluronic acid Versus intralesional injection alone in peyronie's disease: Results from a phase III study

Purpose: The aim of this study was to compare the effect of combined oral administration and intralesional injection of hyaluronic acid (HA) with intralesional injections alone, in patients with early onset of Peyronie's disease (PD). Materials and Methods: For this prospective, randomized phase III clinical trial we included patients with recent diagnosis of PD. Eighty-one patients were randomized into two groups. Group A consisted of 41 patients receiving oral administration of HA in combination with weekly intralesional injection of HA for 6 weeks. Group B consisted of 40 patients group B who received weekly intralesional injections of HA for 6 weeks, only. The main outcome measures were the changes from baseline to the end of therapy after three months in penile curvature (°) and changes in the international index of erectile function (IIEF-5) score and patient's global impressions of improvement (PGI-I) score. Results: Group A had a significantly larger reduction in penile curvature as compared with group B (Group A: -7.8°, Group B: -4.1° [p<0.001]). Group A also showed a higher improvement in IIEF-5 and PGI-I scores in comparison with Group B (Group A: +4 IIEF-5, Group B: +2 IIEF-5 [p<0.001]; Group A: 3 PGI-I, Group B: 1 PGI-I, [p<0.001]). At three months both groups had a significant reduction of penile curvature from baseline (p<0.001). Conclusions: Oral administration combined with intralesional treatment with HA shows greater efficacy to improve penile curvature and overall sexual satisfaction in comparison with intralesional HA treatment alone

Pseudomonas aestus nov. sp. from mangrove sediments: a gluconic acid and betaine producer.

Because of the environmental problems from global warming, the search for microorganisms that promote plant growth under drought and salt conditions is becoming inevitable. A Gram negative bacterium, resistant to 1M salt, gluconic acid and betaine producer and plant growth promoter was isolated from the Brazilian coast mangroves. By the phylogenetic analysis of the 16S rRNA, the strain was included in the taxonomic group of Pseudomonas. Hybridization with type strains and biochemical tests indicate that Pseudomonas strain is a new species. Thus, the name Pseudomonas aestus nov. sp. was proposed and the strain deposited in Embrapa Environment culture collection with the access code CMAA1215

Geodermatophilus marinus sp. npv. associated to the marine sponge Scopalina ruetzleri from São Pedro and São Paulo Archipelago, Equatorial Atlantic, Brazil.

A novel gram-positive, aerobic, actinobacterial strain, CMAA 1362T, was isolated from marine sponge Scopalina ruetzleri collected in the São Pedro and São Paulo Archipelago. São Pedro and São Paulo Archipelago (former Saint Paul`s Rocks) liaison the São Paulo Fracture Zone, 1,010 km northeast from Brazilian mainland in the Equatorial Atlantic Ocean, Brazil (0°54’57”N; 29°20\'41\"W). It is one of the smallest and most isolated archipelagos in the world, with 420 m across, 18 m height and 1.7 ha. The archipelago is under the influence of the South Equatorial Current, driving surface water from east to west, and the Equatorial Undercurrent, moving water in the opposite direction between 40-150 m depth. Tissue samples of the marine sponge Scopalina ruetzleri were collected by SCUBA between 20 and 30 m depth at the East Face of São Pedro and São Paulo Archipelago in August, 2013. This is the first report of marine species of the genera Geodermatophilus. The isolate grew in a temperature range between 15-30°C and pH 6.0-10.0, showed high halotolerance 5-12.5% NaCl (w/v) and black-dry and circular colonies on cultures media. Chemotaxonomic and molecular characteristics of the isolate match those described for members of the genus Geodermatophilus. The DNA G + C content of the genome strain was 69.41 mol%. The major cellular fatty acids were found to be the branched-chain satured acid iso-C16:0 and iso-C15:0, as well as C17:1?8c and C18:1?9c. Molecular analysis of 16S rRNA gene sequence showed 97.2 - 98.4% of pairwise sequence identity with members of the genus Geodermatophilus: Geodermatophilus obscurus (98.4%), Geodermatophilus siccatus (98.3%), Geodermatophilus africanus (98%), Geodermatophilus ruber (97.3%) and Geodermatophilus tzadiensis (97.1%). Based on the results of this polyphasic taxonomic description, the strain type CMAA 1362 represents a novel species, for which the name Geodermatophilus marinus sp. nov. is proposed

Hidrogenionic potential (pH) of the attractant, trap density and control threshold for Ceratitis capitata (Diptera: tephritidae) on Hamlin oranges in São Paulo central region, Brazil

This study evaluated the effect of initial pH values of 4.5, 6.5 and 8.5 of the attractant (protein bait) Milhocina® and borax (sodium borate) in the feld, on the capture of fruit flies in McPhail traps, using 1, 2, 4 and 8 traps per hectare, in order to estimate control thresholds in a Hamlin orange grove in the central region of the state of São Paulo. The most abundant fruit fly species was Ceratitis capitata, comprising almost 99% of the fruit flies captured, of which 80% were females. The largest captures of C. capitata were found in traps baited with Milhocina® and borax at pH 8.5. Captures per trap for the four densities were similar, indicating that the population can be estimated with one trap per hectare in areas with high populations. It was found positive relationships between captures of C. capitata and the number of Hamlin oranges damaged, 2 and 3 weeks after capture. It was obtained equations that correlate captures and damage levels which can be used to estimate control thresholds. The average loss caused in Hamlin orange fruits by C. capitata was 2.5 tons per hectare or 7.5% of production.Esta pesquisa teve como objetivos: avaliar o efeito do pH inicial, 4.5; 6.5 e 8.5, do atrativo proteico Milhocina® e bórax (tetraborato de sódio) na captura de moscas-das-frutas em armadilhas McPhail; estudar densidades de armadilhas, 1; 2; 4 e 8 por hectare, para estimar níveis de controle em laranja cv. Hamlin, na região central de São Paulo. A espécie predominante, com 99% das moscas-das-frutas capturadas, foi Ceratitis capitata, sendo 80% de fêmeas. As maiores capturas de C. capitata ocorreram nas armadilhas com Milhocina® e bórax em pH 8.5. As capturas, nas 4 densidades, foram semelhantes, indicando que a população pode ser estimada com uma armadilha por hectare em áreas de altas populações. Houve relações positivas entre capturas de C. capitata e o número de frutos danificados, 2 e 3 semanas após a captura. Assim, foram obtidas equações que relacionam a captura e o dano, possibilitando estimar níveis de controle desse inseto. As perdas médias causadas por C. capitata em laranja cv. Hamlin chegaram a 2,5 toneladas de frutos por hectare ou 7,5% da produção.info:eu-repo/semantics/publishedVersio