Threats to the Soil Resource Base of Food Security in China and Europe. A report from the Sino-EU Panel on Land and Soil

To secure adequate food supply is the major challenge for humanity in the 21st century. Growing world population and its urbanization put pressure on this basic need, which is further threatened by the constant loss of fertile land. The assessment of sustainability of food supply under increasing pressure on land resources has been selected as one of the most important priority topics of the activities of Sino-EU Panel on Land and Soil (SEPLS). The Panel has performed a number of related researches and discussed the results on a scientific seminar in January 2012 in Nanjing, China. This report is an output of this seminar with a summary of the structured discussions on the below issues. 1. Urban and peri-urban development (soil sealing and loss of land functions) Urbanization and the linked spread of infrastructural development mean sealing of soil surfaces. Soil sealing is the most rapidly growing limitation for soil functions (including biomass production function) both in China and Europe. Soil sealing in China has been taking dramatic degree in the last two decades and the process is estimated to continue in the coming period as well. While urban and peri-urban development is looked as a necessity for social development, its negative effect on natural resources are inevitable. 2. Land degradation Despite the widely recognized importance of land degradation in the unsustainability of economic development and implementation of various policies to halt degradation (e.g. green for grain programme in China; cross-compliance measures in the EU), loss of land productivity by degradation is an ongoing process both in China and the EU. Major forms of soil degradation (erosion, desertification, landslides etc.) are similar in both regions. Assessment of the causes and consequences of soil degradation processes in relation to policy actions is highlighted among the priorities of the SEPLS. 3. Intensive agriculture and multi-function management of land resources Intensification and extensification in agriculture can be considered as the main changes in land use in rural areas in both EU and China. While agricultural intensification is one of the greatest threats to the soil and environment and then hampers the sustainable development of agriculture and food security. To meet this challenge, sustainable management of multi-functionality of land resources is undoubtedly an effective strategy, in which the EU has a good expertise. Bilateral exchange of the experience and knowledge benefits the sustainable management of land resources.JRC.H.5-Land Resources Managemen

Relationship between lung function impairment, hypertension, and major adverse cardiovascular events: A 10‐year follow‐up study

Abstract Lung function impairment and hypertension, especially hypertension, are risk factors of major adverse cardiovascular events (MACEs). However, the relationships among lung function impairment, hypertension, and MACEs have not been well‐reported. We aimed to investigate the association between lung function and hypertension and MACEs. We studied 6769 people who were a representative sample of the general population in Jiangsu Province using the multi‐stage stratified cluster sampling method. The average age was 51.54 years. Cox proportional hazards models were used to analyze the relationships between the blood pressure status and various types of lung function impairment related to MACEs. Over a follow‐up of 10 years, 236 MACEs occurred. After adjusting for age, sex, BMI, smoking, drinking, education, physical activity, diabetes mellitus, dyslipidemia, creatine and use of antihypertensive drugs, hypertension [hazard ratio (HR) = 2.154, 95% confidence intervals (CI): 1.565–2.966], and restrictive lung function impairment (RLFI) (HR = 1.398, 95% CI: 1.021–1.879) were independently associated with MACEs. Individuals with hypertension and RFLI had the highest risk for MACEs (HR = 2.930, 95% CI: 1.734–4.953) and stroke (HR = 3.296, 95% CI: 1.862–5.832). Moreover, when combined with hypertension, obstructive lung function impairment (OLFI) (HR = 2.376, 95% CI: 1.391–4.056) and mixed lung function impairment (MLFI) (HR = 2.423, 95% CI: 1.203–4.882) were associated with MACEs. There is a synergistic effect of lung function impairment (especially RLFI) and hypertension on MACEs. Therefore, more attention should be paid to the incidence of MACEs in individuals with impaired lung function, especially those who have hypertension

2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione isolated from Averrhoa carambola L. root inhibits high glucose-induced EMT in HK-2 cells through targeting the regulation of miR-21–5p/Smad7 signaling pathway

Objective: 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione (DMDD) isolated from Averrhoa carambola L. root, has been proven therapeutic effects on diabetic kidney disease (DKD). This research aims to assess DMDD’s effects on DKD and to investigate its underlying mechanisms, to establish DMDD as a novel pharmaceutical agent for DKD treatment. Methods: The human renal tubular epithelial (HK-2) cells were induced by high glucose (HG) to mimic DKD and followed by DMDD treatment. The cytotoxicity of DMDD was assessed using the Cell Counting Kit-8 (CCK-8) assay. The migratory capacity of HK-2 cells was evaluated through transwell and scratch-wound assays. To investigate the effect of Smad7 and miR-21–5p, lentiviral transfection was employed in HK-2 cells. Additionally, the expression of proteins related to epithelial-mesenchymal transition (EMT) and TGFβ1/Smad2/3 pathway was checked by QRT-PCR, Western blot, and immunofluorescence techniques. Results: This study has shown that DMDD significantly suppresses cell migration and the expression of Vimentin, α-SMA, TGFβ1, and p-Smad2/3 in HK-2 cells under HG conditions. Concurrently, DMDD enhances the protein expression of E-cadherin and Smad7. Intriguingly, the therapeutic effect of DMDD was abrogated upon Smad7 silencing. Further investigations revealed that DMDD effectively inhibits miR-21–5p expression, which is upregulated by HG. Downregulation of miR-21–5p inhibits the activation of the TGFβ1/Smad2/3 pathway and EMT induced by HG. In contrast, overexpression of miR-21–5p negates DMDD’s therapeutic benefits. Conclusion: DMDD mitigates EMT in HG-induced HK-2 cells by modulating the miR-21–5p/Smad7 pathway, thereby inhibiting renal fibrosis in DKD. These findings suggest that DMDD holds promise as a potential therapeutic agent for DKD

GlobalSoilMap: Toward a Fine-Resolution Global Grid of Soil Properties

Soil scientists are being challenged to provide assessments of soil condition from local through to global scales. A particular issue is the need for estimates of the stores and fluxes in soils of water, carbon, nutrients, and solutes. This review outlines progress in the development and testing of GlobalSoilMap—a digital soil map that aims to provide a fineresolution global grid of soil functional properties with estimates of their associated uncertainties. A range of methods can be used to generate the fine-resolution spatial estimates depending on the availability of existing soil surveys, environmental data, and point observations. The system has an explicit geometry for estimating point and block estimates of soil properties continuously down the soil profile. This geometry is necessary to ensure mass balance when stores and fluxes are computed. It also overcomes some limitations with existing systems for characterizing soil variation with depth. GlobalSoilMap has been designed to enable delivery of soil data via Web services. This review provides an overview of the system's technical specifications including the minimum data set. Examples from contrasting countries and environments are then presented to demonstrate the robustness of the technical specifications. GlobalSoilMap provides the means for supplying soil information in a format and resolution compatible with other fundamental data sets from remote sensing, terrain analysis, and other systems for mapping, monitoring, and forecasting biophysical processes. The initial research phase of the core project is nearing completion and attention is now shifting toward establishing the institutional and governance arrangements necessary to complete a full global coverage and maintaining the operational version of the GlobalSoilMap. This will be a grand and rewarding challenge for the soil science profession in the coming years.JRC.H.5-Land Resources Managemen