Top quark, heavy fermions and the composite Higgs boson

We study the properties of heavy fermions in the vector-like representation of the electro-weak gauge group $SU(2)_W\times U(1)_Y$ with Yukawa couplings to the standard model Higgs boson. Applying the renormalization group analysis, we discuss the effects of heavy fermions to the vacuum stability bound and the triviality bound on the mass of the Higgs boson. We also discuss the interesting possibility that the Higgs particle is composed of the top quark and heavy fermions. The bound on the composite Higgs mass is estimated using the method of Bardeen, Hill and Lindner, 150GeV$\leq m_H\leq$ 450GeV.Comment: 10 pages and 6 figures. This paper replaces and is an extended version of hep-ph/9602340 (published in Phys. Lett. B370(1996)201;Erratum B382(1996)448

A STUDY ON THE ISSUE OF INNOVATIVE INDUSTRIAL CONSTRUCTION AND INNOVATIVE INDUSTRIAL CLUSTER IN BUILDING AN INNOVATIVE NINGXIA

To construct an Innovative Ningxia and develop its economy by leaps and bounds, This paper puts forward the necessity and urgency of adjusting and optimizing the industrial structure in Ningxia, it analyses the conclusion and enlightenment of theoretical research on the industrial cluster and the experience and enlightenment of the development of innovative industrial cluster at home and abroad, it pointes the tendency and the barriers to the industrial cluster in Ningxia, it advances the goal, direction and measures of innovative clusters development and construction in Ningxia. Key words: industrial structure, industrial cluster, innovative industrial construction, innovative industrial cluster, innovative Ningxi

A novel Toxoplasma gondii TGGT1_316290 mRNA-LNP vaccine elicits protective immune response against toxoplasmosis in mice

Toxoplasma gondii (T. gondii) can infect almost all warm-blooded animals and is a major threat to global public health. Currently, there is no effective drug or vaccine for T. gondii. In this study, bioinformatics analysis on B and T cell epitopes revealed that TGGT1_316290 (TG290) had superior effects compared with the surface antigen 1 (SAG1). TG290 mRNA-LNP was constructed through the Lipid Nanoparticle (LNP) technology and intramuscularly injected into the BALB/c mice, and its immunogenicity and efficacy were explored. Analysis of antibodies, cytokines (IFN-γ, IL-12, IL-4, and IL-10), lymphocytes proliferation, cytotoxic T lymphocyte activity, dendritic cell (DC) maturation, as well as CD4+ and CD8+ T lymphocytes revealed that TG290 mRNA-LNP induced humoral and cellular immune responses in vaccinated mice. Furthermore, T-Box 21 (T-bet), nuclear factor kappa B (NF-kB) p65, and interferon regulatory factor 8 (IRF8) subunit were over-expressed in the TG290 mRNA-LNP-immunized group. The survival time of mice injected with TG290 mRNA-LNP was significantly longer (18.7 ± 3 days) compared with the survival of mice of the control groups (p < 0.0001). In addition, adoptive immunization using 300 μl serum and lymphocytes (5*107) of mice immunized with TG290 mRNA-LNP significantly prolonged the survival time of these mice. This study demonstrates that TG290 mRNA-LNP induces specific immune response against T. gondii and may be a potential toxoplasmosis vaccine candidate for this infection