Synthesis, characterization, spectroscopic properties, theoretical calculation, and antimicrobial activity of new aryldisulfonamides

WOS: 000289965000004New aryldisulfonamides were synthesized and characterized by FTIR, (1)H NMR, (13)C NMR, HETCOR, COSY, LC-MS and elemental analysis techniques. The compounds gave intense emissions, where lambda(max) = 405, 379 and 402 nm, upon irradiation by Ultra-Violet light. The photoluminescence quantum yields and long excited-state lifetimes of the compounds were calculated and were found to have photoluminescence quantum yields 39 +/- 1.8%, 45 +/- 2.2% and 34 +/- 1.4% and long excited-state lifetimes of 3.65 +/- 0.16, 4.17 +/- 0.20 and 3.15 +/- 0.12 ns, respectively. The photoluminescence intensities and quantum yields of compounds varied with the position of substituent on the ring and the chain length between aromatic rings. These novel compounds may be of interest as organic emitting materials for electroluminescent devices. The visible absorption maxima were calculated using time-depended density-functional theory (ID-OFT) and Zerner's intermediate neglect of differential overlap/spectroscopic (ZINDO/S) method in the gas phase. Further, the compounds were evaluated for in vitro antimicrobial activity against various microorganisms by microdilution and disk diffusion methods. (C) 2011 Elsevier B.V. All rights reserved.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG 104 T 390, MAG 104M 367]; Gazi University Scientific Research ProjectGazi University [05/2008-05]The authors wish to thank TUBITAK for the financial support (TBAG 104 T 390 and (MAG 104M 367) and Gazi University Scientific Research Project (05/2008-05). We would also like to thank the Departments of Chemistry at Gazi University and Gaziantep University

The Pediatric Tracheostomy Practice During COVID-19 Pandemic at a PICU

Introduction:To evaluate pediatric tracheostomies performed at a tertiary care pediatric intensive care unit (PICU) before and after the Coronavirus disease-2019 (COVID-19) pandemic.Methods:A total of 57 pediatric tracheostomy patients performed at a tertiary care PICU were included. Prognostic scores including pediatric risk of mortality 2, pediatric index of mortality 2 and pediatric logistic organ dysfunction scores, the family education process and time to home discharge were evaluated according to time of tracheostomy (pre-pandemic vs. after pandemic) and responsible surgeon (pediatric surgeon vs. otolaryngologist). MedCalc® Statistical Software version 19.7.2 (MedCalc Software Ltd, Ostend, Belgium; https: //www.medcalc.org; 2021) was used for statistical analysis.Results:A non-significant tendency for higher rate of pediatric surgery-based tracheostomies was noted after the pandemic (76.0 vs. 24.0%, p=0.134). No significant difference was noted between tracheostomies performed before vs. after the COVID-19 pandemic and those performed by otolaryngologists vs. pediatric surgeons in terms of prognostic scores and time to home discharge.Conclusion:Our findings emphasize the maintenance of high quality patient care for pediatric tracheostomy patients in accordance with standardized tracheostomy protocols and policies during the pandemic period with no significant difference between tracheostomies performed before and after the COVID-19 pandemic and those performed by pediatric surgeons vs. otolaryngologists in terms of prognostic scores and time to home discharge

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ABSTRACT Context Heterotopic pancreas is defined as the presence of pancreatic tissue, outside its usual location, which lacks anatomical and vascular continuity with the pancreas proper. Despite the development of modern diagnostic procedures, it is still difficult to differentiate heterotopic pancreas from benign or malignant tumors and other tumor-like lesions. Frozen examination of mucinous lesions arising from heterotopic pancreas may represent a diagnostic problem. A decision may be very difficult and it is sometimes impossible to decide on the basis of the frozen sections whether a lesion is benign or malignant. Case report We report a tumor-like lesion mimicking a mucinous (colloid) carcinoma arising in heterotopic pancreatic tissue in the prepyloric antrum of a 56-year-old woman which was found incidentally during an elective laparoscopic cholecystectomy for cholelithiasis. The tumor was treated by wedge resection and, in the frozen section examination, there were pancreatic ducts in the proper muscle layer, pancreatic acini with islets of Langerhans under the serosal surface and mucinous lakes close to the heterotopic pancreatic tissue and to a peripheral nerve. Conclusion The significance of this unusual lesion is its potential confusion with mucinous (colloid) carcinoma or other mucous tumors. Such confusion is more likely to occur if the tissue sample is selective or limited, and the presence of pancreatic tissue cannot be verified. Therefore, we believe that a choice of local excision, wedge resection or more extensive eradication be determined only after intraoperative, pathological confirmation of the complete and accurate diagnosis

A Rare Cardiotoxicity: Butane Inhalation

The number of cases of voluntary inhalation of volatile substances is increasing all over the world and in our country. This is a social health problem that can be encountered in different socioeconomic and cultural levels. The number of applications to pediatric emergency services cannot be underrated because the age of first use of such illegal substances has decreased gradually. Inhalation of volatile substances can cause pathologies in a very broad spectrum, including sudden death. In this paper, we report a case of cardiac arrest developing after lighter fluid inhalation

Doğumsal nazolakrimal kanal tıkanıklığı tedavisinde sondalama yönteminin etkinliği ve zamanlaması

Objective: To evaluate the efficacy of probing in patients with congenital nasolacrimal duct obstruction (CNLDO) and to evaluate the success rates with respect to their effectiveness, and age groups. Methods: the charts of patients who underwent probing for congenital nasolacrimal duct obstruction between 2010 and 2012 were retrospectively reviewed. Patients’ ages at the time of probing, the presence of watering complaints and epiphoras, and fluorescein dye disappearance test results after the procedure were recorded. Postoperative follow- up, safety and efficacy were evaluated according to age groups. Results: Eighty-four patients (46 girls (55.0%), and 38 boys (45.0%) diagnosed as congenital nasolacrimal duct obstruction were included in the study. the mean age of patients was 16.4 months (12-34 month) and mean follow- up period was 10.4 months (6-18 months). Forty-six patients were between 12 and 24 months, and 38 patients were over 24 months. By probing, success was achieved in 78 of 105 eyes (74.3%). According to the age groups, success rate of probing was 86.7% (52 of 60 eyes) in patients between 12-24 months and 57.7% (26 eyes of 45 patients) in those over 24 months. No complications were noted during follow-up. Conclusion: Probing is an effective treatment for congenital nasolacrimal duct obstruction in cases not improving with conservative treatment in the early age group. As the age increases, the chance of success decreases, thus the application should not be delayed.Amaç: Doğumsal nazolakrimal kanal tıkanıklığı (DNLKT) olan hastalarda sondalama tedavisinin etkinlik ve yaş gruplarına göre başarı oranlarını değerlendirmek. Yöntemler: Bu çalışmada, DNLKT nedeni ile 2010-2012 yılları arasında sondalama işlemi uygulanan hastaların kayıtları retrospektif olarak incelendi. Hastaların sondalama yapıldığı zamandaki yaşı, işlem sonrası sulanma yakınmalarının durumu, epiforanın varlığı ve floresein kaybolma testinin sonuçları not edildi. Ameliyat sonrası dönemde işlemin başarısı ve komplikasyonlar yaş gruplarına göre değerlendirildi. Bulgular: Doğumsal nazolakrimal kanal tıkanıklığı tanısı alan 46 kız (%55.0), 38 erkek (%45.0) toplam 84 hasta çalışmaya alındı. Olguların yaş ortalaması 16.4 ay (12-34 ay) ve ortalama takip süresi 10.4 ay (6-18 ay) idi. Olguların 46’sı 12-24 ay arasında, 38’i 24 aydan büyüktü. Sondalama ile 105 gözün 78’inde (%74.3) başarı sağlandı. Yaş gruplarına göre değerlendirildiğinde sondalama ile başarı oranı, 12-24 ay grubunda %86.7 (60 gözün 52’si), 24 ayın üzerindeki hastalarda ise %57.7 (45 gözün 26’sı) olarak saptandı. Olguların hiçbirinde takip süresi boyunca herhangi bir komplikasyon izlenmedi. Sonuç: Konservatif tedavi ile yaşamın ilk yılında düzelmeyen doğumsal nazolakrimal kanal tıkanıklığı olguları için sondalama işlemi erken yaş gruplarında etkili bir tedavi şeklidir. Hastanın yaşı arttıkça başarı şansı azalacağı için uygulamada geç kalınmaması gerekmektedir

Çocuklardaki bakteriyel konjonktivit tedavisinde azitromisin (%1,5) ile netilmisin (%0.3) göz damlasının karşılaştırılması

Objective: To compare the safety and efficacy of 1.5% azithromycin eye drops with 0.3% netilmicin ophthalmic solution in a pediatric population with purulent bacterial conjunctivitis. Methods: Patients received either azithromycin (1.5%) (Group 1) (twice daily for 3 days) or netilmicin (0.3%) (Group 2) eye drops (four times daily for 7 days) to treat bacterial conjunctivitis. Clinical signs were evaluated on day 3 and 7. the primary variable was the clinical cure (absence of bulbar conjunctival injection and discharge) on day 3 for Group 1 and day 7 for Group 2. Results: A total of 92 patients were randomized, and both study medications were well tolerated. Clinical signs were evaluated on day 3 and 7. Clinical cure rate was similar between two groups (91.3% vs 89.3%, respectively). the most frequently observed ocular adverse events in the azithromycin group were eye irritation (15.2%) and con- junctival hyperemia (13.0%) in the netilmicin %0.3 group. Conclusion: Despite their similar clinical responses in the treatment of children with bacterial conjunctivitis, azithromycin (1.5%) eye drops is safe and can be administered with a more convenient twice-a-day dosing regimen.when compared with netilmicin (0.3%) eye drops.Amaç: Bu çalışmada çocuklardaki bakteriyel konjonktivit tedavisinde azitromisin %1,5 göz damlası ile netilmisin %0.3 göz damlasının tedavideki etkinlik ve güvenirliliğinin karşılaştırılması amaçlanmıştır. Yöntemler: Hastalara bakteriyel konjonktivit tedavisi için azitromisin %1,5 (Grup 1) göz damlası (3 gün günde 2 kez) veya netilmisin %0,3 (Grup 2) göz damlası (günde 4 kez 1 hafta boyunca) uygulanmıştır. Klinik bulgular 3. ve 7. günde değerlendirilmiş - tir. Klinik iyileşme (konjonktival hiperemi ve sekresyonun olmaması) Grup 1’de 3. gün, Grup 2’de 7. gün değerlendirilmiştir. Bulgular: Toplam 92 olgu randomize edilmiş ve iki grupta da tedavi iyi tolere edilmiş tir. Klinik yanıt 3. ve 7. günde değerlendirilmiştir. Tedavi yanıtı iki grupta da birbirine yakın saptanmıştır. (sırasıyla, %91,3 ve %89,1). En sık rastlanan oküler yan etki azitromisin grubunda göz irritasyonu (%15,2) iken, netilmisin %0,3 grubunda kon- jonktival hiperemi (%13,0) olarak görülmüştür. Sonuç: Çocuklardaki bakteriyel konjonktivit tedavisinde, benzer klinik yanıtlar görülmüş olsa da, azitromisin %1,5 göz damlası netilmicin %0.3 göz damlasına göre daha kısa süreli ve günde iki kez uygulanması açısından daha uygun ve güvenilir gözükmektedir

Iatrogenic calcinosis cutis at upper eyelid following extravasation of calcium gluconate from inappropriate intravenous cannula

Purpose: To report a case of iatrogenic calcinosis at the upper eyelid region due to inappropriate placement of intravenous cannula and extravasation of calcium gluco - nate. Case report: A 3970-g female neonate withedema and erythema and a firm mass on the temple, forehead and right upper eyelid was evaluated. Subcutaneous calcium deposition was only seen on the upper eyelid. With the diagnosis of neonatal hypocal- cemia, she was treated with intravenous calcium gluconate injected into the superfici- al temporal vein on the right temple. Results: Calcium gluconate was discontinued, the cannula was removed and warm compresses were applied. At 13 th day of her life the size of the firm lesion had mar- kedly resolved however subcutaneus calcium deposits remained. At the second month after delivery, routine control examination revealed no sequela.Amaç: Uygun biçimde yerleştirilmeyen intravenöz kanmülden kalsiyum glukonatın damar dışına sızması sonucu üst göz kapağında kalsinozis saptanan bir olgunun sunulması amaçlanmıştır. Olgu sunumu: Üst göz kapağı, şakak ve alın bölgesinde hiperemi ve ödem saptanan 3970 g yenidoğan olgu değerlendirilmiştir. Cilt altı kalsiyum birikimi yalnızca sağ üst göz kapağında izlenmekteydi. Olguya nonatal hipokalsemi nedeni ile süperfisiyal temporal venden inravenöz kasiyum glukonat verilmişti. Sonuç: Kalsiyum glukonat tedavisi kesilip, kanül çıkarıldı ve sıcak baskı uygulandı. on üçüncü günde sert lezyon geriledi fakat cilt altı kalsiyum birikimi devam etmekteydi. İki ay sonra yapılan kontrolde hiçbir sekel kalmadığı görüldü