Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Advanced production routes for metal matrix composites

The use of metal matrix composites (MMCs) in a variety of products is significantly increasing with time due to the fact that their properties can be tailored and designed to suit specific applications. However, the future usage of MMC products is very much dependent on their beneficial aspects and hence it is critical to ensure in a robust repeatable manner the superior physical property advantages compared to conventional unreinforced monolithic metal counterparts. Although numerous routes are available for production of MMC products, each of them has their own advantages and disadvantages. This article provides an overview of advanced production routes for MMCs. The discussion also highlights challenges and presents a future prospectus for MMCs. Powder metallurgy and casting routes are still extensively used for production of MMCs. Aluminum alloys are today the most commonly used matrix materials in MMC products. Carbides (eg, SiC, TiC, and B4C), carbon allotropes (eg, CNTs and graphene), and alumina (Al2O3) are currently the most used reinforcement materials. Nevertheless, the use of nano and of hybrid reinforcements are seeing increased usage in niche applications. Additive manufacturing (AM) is discussed as a novel production route for MMC products. This process represents a promising method for the production of MMC products

Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. In the last two decades, the prevalence of NAFLD has been growing in most developed countries, mainly as a consequence of its close association with obesity and diabetes mellitus. The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression have not been completely understood. Adipocytes produce and secrete several bioactive substances known as adipocytokines which are implicated in the pathogenesis of the disease. Among them, adiponectin is an insulin-sensitizing adipocytokine possessing multiple beneficial effects on obesity-related medical complication. This review focuses on the role of adiponectin in NAFLD pathogenesis and its potential use as a diagnostic tool but also as therapeutic target for NAFLD management