Analisis Rantai Pasok Produk Beras dari Kabupaten Konawe Selatan ke Kota Kendari

This study aims to find out how the supply chain of rice from South Konawe to Kendari. This type of research is included in descriptive research or categorized in qualitative research method by using survey method that is described, explain and interpret a phenomenon that occurs on an object and data is qualitative, ie data that is described with words or sentences by category to obtain a conclusion. This research was conducted in South Konawe Village specifically at UD. Fandi in Laeya District, South Konawe District in August 2017. Data collection techniques were conducted through observation, interviews, discussions with supply chain members and documentation at the research sites. Supply Chain of rice products from South Konawe District to Kendari City starts from Farmers, Rice Millers, Distributors UD Fandi, Retailer and Final Consumer. Farmers as rice suppliers cultivate and sell their crops to the rice mills, then the mills' process rice from farmers into rice products to be sold to Distributor. In this research, the Distributor Party also as the owner of rice milling, after the packaging of rice products, will then be distributed to retailers both in South Konawe District itself and outside the region, especially Kendari City distributor of UD. Fandi has a rice warehouse which is a shelter of rice products that will be sold to retailers in Kendari City. The selling price of rice products from Distributor UD. Fandi is accepted by retailers in South Konawe and outside Kendari especially divided by size, for rice with size 50 kg sold with price Rp. 420.000, - and for rice with size 25 kg sold with price Rp. 220.000, Furthermore the retailers will repackage the rice products into several sizes that are tailored to the needs of the end consumer is the size of 10 kg, and size 5 kg. for rice with size 10 kg sold with price Rp. 110.000, - and rice with size 5 kg sold with price Rp. 55.000, -. But retailers also sell rice with liter sizes which for liters sold to consumers at a price of Rp. 8,000-8,500, / litres. This is done to adjust to the level of end consumer needs

Analisis Pendapatan Usahatani Padi Sawah dan Sayuran di Desa Dawi-Dawi Kecamatan Wonggeduku Kabupaten Konawe

This research aims to find out Paddy and vegetable farm income, and Paddy and vegetable farm efficiency in Dawi-Dawi Village, Wonggeduku Subdistrict, Konawe Regency. The population of this research is comprised of all farmers who grow paddy and plant vegetables (tomato and yardlong bean) in Dawi-Dawi Village, Wonggeduku Subdistrict, Konawe Regency which consist of 21 farmers. Samples are taken using census method, in which all of the population is taken as research sample. Therefore, a number of samples in this research are 21 farmers. The data are analyzed using income analysis, namely, Pd = TR TC and farm efficiency analysis R/C Ratio = TR/TC. The results show that: (1) paddy farm incomes per season range from IDR 1,901,250 – IDR 24,492,250 with the average of IDR 7,697,670. Tomato farm incomes per season range from IDR 1,979,772 – IDR 25,351,820 with an average of IDR 7,970,189. Yardlong bean farm incomes per season range from IDR 1,532,389 – IDR 3,391,000 with an average of IDR 1,822,370, and (2) Paddy, tomato and yardlong bean farms are deemed efficient with the R/C ratio of 2.73, 2.97, and 3.13 respectively

HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers

Valproic acid (VPA), a histone deacetylase inhibitor, causes differentiation in different cell lines and in a cell-specific manner; yet, its effect on megakaryocytic (MK) differentiation has not been studied. We evaluated whether VPA induces MK differentiation in a UT-7 cell line through histone acetylation in the GpIIIa gene region and activation of the ERK pathway. UT-7 cells, derived from megakaryoblastic leukemia, were treated with VPA at various concentrations, and the expression of differentiation markers as well as the gene expression profile was assessed. Flow cytometry, immunoblot analysis, and RT-PCR demonstrated that VPA induced the expression of the early MK markers GpIIIa (CD61) and GpIIb/IIIa (CD41) in a dose-dependent manner. The VPA-treated cells showed hyperacetylation of the histones H3 and H4; in particular, histone acetylation was found to have been associated with CD61 expression, in that the GpIIIa promoter showed H4 hyperacetylation, as demonstrated by the chromatin immunoprecipitation assay. Furthermore, activation of the ERK pathway was involved in VPA-mediated CD61/CD41 expression and in cell adhesion, as demonstrated by using the MEK/ERK inhibitor U0126. In conclusion, the capacity of VPA to commit UT-7 cells to MK differentiation is mediated by its inhibitory action on HDAC and the long-lived activation of ERK1/2

Analisis Persediaan Bahan Baku pada Usaha Mete di Kota Kendari (Studi Kasus pada UD. Mete Mubaraq Lombe)

This research aims to know the inventory of raw cashew nuts peeled on UD. Mete Mubaraq Lombe of the year 2017; Analyze the efficiency of the inventory of raw materials according to the EOQ method on UD. Mete Mubaraq Lombe; determine the Safety Stock and Reorder Point at UD. Mete Mubaraq Lombe. The study was designed as a case study of using primary data and secondary data, variables in this study include a Total Inventory Cost, Ordering Cost and Carrying Cost. There were some of the results obtained in this study. First, the type of raw materials used is cashew nuts peeled from Region Lombe by way of partnering. The volume of purchase of raw materials over the past year as many as 52,000 kg. Booking fees during the year 2017 are Rp 43,872,000. Storage costs during the year 2017 are Rp 48,144,000. Secondly, the supply of raw materials of peeled cashew nuts more efficiently by using the EOQ method. It can be seen from the difference in TIC companies issued in the year 2017 is Rp. 45,878,000.4 while the EOQ method based on the TIC of Rp 18,762,434.4. So the difference in TIC is Rp. 27,115,566. Thirdly, in order not to run out of stock in the warehouse, then the safety stock that must always be available in the company as much as 1,459.26 kg and company do a reorder point when the raw materials in the warehouse as much as 1,690.46 kg

Examining the determination of flood victim’s knowledge sharing behavior: From the perspectives of social cognitive theory

During the occurrence of disaster, knowledge sharing plays as important role. Through effective knowledge sharing, it can help victims save lives; received immediate relief and support; and minimize the disaster effect. But lack of works has been done to examine the determinants of knowledge sharing within disaster management context.Therefore, this study aims to provide a better understanding of knowledge sharing during the occurrence of disaster.In order to examine the determinant of individual’s knowledge sharing behavior during the occurrence of disaster, the researcher will use social cognitive theory (SCT) to conceptualize a theoretical model for this study.This study holds self-efficacy, reciprocity, social support and social recognition as an influence individual in sharing knowledge during the occurrence of disaster.The methodology begins with constructing a questionnaire to investigate the theoretical model. The respondents are victims that have had experience in sharing knowledge during the flood.This study was used a Structural Equation Modeling (SEM) to test causal relationships between constructs.Hopefully, by proposed theoretical model through this research can provide additional insight on what influence knowledge sharing behavior within disaster management context

Neural markers of a greater female responsiveness to social stimuli

Abstract Background There is fMRI evidence that women are neurally predisposed to process infant laughter and crying. Other findings show that women might be more empathic and sensitive than men to emotional facial expressions. However, no gender difference in the brain responses to persons and unanimated scenes has hitherto been demonstrated. Results Twenty-four men and women viewed 220 images portraying persons or landscapes and ERPs were recorded from 128 sites. In women, but not in men, the N2 component (210–270) was much larger to persons than to scenes. swLORETA showed significant bilateral activation of FG (BA19/37) in both genders when viewing persons as opposed to scenes. Only women showed a source of activity in the STG and in the right MOG (extra-striate body area, EBA), and only men in the left parahippocampal area (PPA). Conclusion A significant gender difference was found in activation of the left and right STG (BA22) and the cingulate cortex for the subtractive condition women minus men, thus indicating that women might have a greater preference or interest for social stimuli (faces and persons).</p

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay

The molecular mechanisms by which glioblastoma multiforme (GBM) refracts and becomes resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly due to the presence of hypoxic regions, which are frequently found in GBM tumors. We investigated the radiosensitizing effects of MEK/ERK inhibition on GBM cell lines under hypoxic conditions. Four human GBM cell lines, T98G, U87MG, U138MG and U251MG were treated with the MEK/ERK inhibitor U0126, the HIF-1α inhibitor FM19G11 or γ-irradiation either alone or in combination under hypoxic conditions. Immunoblot analysis of specific proteins was performed in order to define their anti‑oncogenic or radiosensitizing roles in the different experimental conditions. MEK/ERK inhibition by U0126 reverted the transformed phenotype and significantly enhanced the radiosensitivity of T98G, U87MG, U138MG cells but not of the U251MG cell line under hypoxic conditions. U0126 and ERK silencing by siRNA reduced the levels of DNA protein kinase catalytic subunit (DNA-PKcs), Ku70 and K80 proteins and clearly reduced HIF-1α activity and protein expression. Furthermore, DNA-PKcs siRNA-mediated silencing counteracted HIF-1α activity and downregulated protein expression suggesting that ERKs, DNA-PKcs and HIF-1α cooperate in radioprotection of GBM cells. Of note, HIF-1α inhibition under hypoxic conditions drastically radiosensitized all cell lines used. MEK/ERK signal transduction pathway, through the sustained expression of DNA-PKcs, positively regulates HIF-1α protein expression and activity, preserving GBM radioresistance in hypoxic condition