392 research outputs found
Steady Stokes flow with long-range correlations, fractal Fourier spectrum, and anomalous transport
We consider viscous two-dimensional steady flows of incompressible fluids
past doubly periodic arrays of solid obstacles. In a class of such flows, the
autocorrelations for the Lagrangian observables decay in accordance with the
power law, and the Fourier spectrum is neither discrete nor absolutely
continuous. We demonstrate that spreading of the droplet of tracers in such
flows is anomalously fast. Since the flow is equivalent to the integrable
Hamiltonian system with 1 degree of freedom, this provides an example of
integrable dynamics with long-range correlations, fractal power spectrum, and
anomalous transport properties.Comment: 4 pages, 4 figures, published in Physical Review Letter
Modeling rhythmic patterns in the hippocampus
We investigate different dynamical regimes of neuronal network in the CA3
area of the hippocampus. The proposed neuronal circuit includes two fast- and
two slowly-spiking cells which are interconnected by means of dynamical
synapses. On the individual level, each neuron is modeled by FitzHugh-Nagumo
equations. Three basic rhythmic patterns are observed: gamma-rhythm in which
the fast neurons are uniformly spiking, theta-rhythm in which the individual
spikes are separated by quiet epochs, and theta/gamma rhythm with repeated
patches of spikes. We analyze the influence of asymmetry of synaptic strengths
on the synchronization in the network and demonstrate that strong asymmetry
reduces the variety of available dynamical states. The model network exhibits
multistability; this results in occurrence of hysteresis in dependence on the
conductances of individual connections. We show that switching between
different rhythmic patterns in the network depends on the degree of
synchronization between the slow cells.Comment: 10 pages, 9 figure
Noise Induced Complexity: From Subthreshold Oscillations to Spiking in Coupled Excitable Systems
We study stochastic dynamics of an ensemble of N globally coupled excitable
elements. Each element is modeled by a FitzHugh-Nagumo oscillator and is
disturbed by independent Gaussian noise. In simulations of the Langevin
dynamics we characterize the collective behavior of the ensemble in terms of
its mean field and show that with the increase of noise the mean field displays
a transition from a steady equilibrium to global oscillations and then, for
sufficiently large noise, back to another equilibrium. Diverse regimes of
collective dynamics ranging from periodic subthreshold oscillations to
large-amplitude oscillations and chaos are observed in the course of this
transition. In order to understand details and mechanisms of noise-induced
dynamics we consider a thermodynamic limit of the ensemble, and
derive the cumulant expansion describing temporal evolution of the mean field
fluctuations. In the Gaussian approximation this allows us to perform the
bifurcation analysis; its results are in good agreement with dynamical
scenarios observed in the stochastic simulations of large ensembles
Using the Hadamard and related transforms for simplifying the spectrum of the quantum baker's map
We rationalize the somewhat surprising efficacy of the Hadamard transform in
simplifying the eigenstates of the quantum baker's map, a paradigmatic model of
quantum chaos. This allows us to construct closely related, but new, transforms
that do significantly better, thus nearly solving for many states of the
quantum baker's map. These new transforms, which combine the standard Fourier
and Hadamard transforms in an interesting manner, are constructed from
eigenvectors of the shift permutation operator that are also simultaneous
eigenvectors of bit-flip (parity) and possess bit-reversal (time-reversal)
symmetry.Comment: Version to appear in J. Phys. A. Added discussions; modified title;
corrected minor error
Derivation of the Effective Chiral Lagrangian for Pseudoscalar Mesons from QCD
We formally derive the chiral Lagrangian for low lying pseudoscalar mesons
from the first principles of QCD considering the contributions from the normal
part of the theory without taking approximations. The derivation is based on
the standard generating functional of QCD in the path integral formalism. The
gluon-field integration is formally carried out by expressing the result in
terms of physical Green's functions of the gluon. To integrate over the
quark-field, we introduce a bilocal auxiliary field Phi(x,y) representing the
mesons. We then develop a consistent way of extracting the local pseudoscalar
degree of freedom U(x) in Phi(x,y) and integrating out the rest degrees of
freedom such that the complete pseudoscalar degree of freedom resides in U(x).
With certain techniques, we work out the explicit U(x)-dependence of the
effective action up to the p^4-terms in the momentum expansion, which leads to
the desired chiral Lagrangian in which all the coefficients contributed from
the normal part of the theory are expressed in terms of certain Green's
functions in QCD. Together with the existing QCD formulae for the anomaly
contributions, the present results leads to the complete QCD definition of the
coefficients in the chiral Lagrangian. The relation between the present QCD
definition of the p^2-order coefficient F_0^2 and the well-known approximate
result given by Pagels and Stokar is discussed.Comment: 16 pages in RevTex, some typos are corrected, version for publication
in Phys. Rev.
Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment
BACKGROUND: Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor transgenic mouse persisted long after adoptive transfer as memory T cells. When recipient mice were challenged with the OVA-expressing E.G7 thymoma, tumor growth was delayed and sometimes prevented. The reasons for therapeutic failures were not clear. METHODS: OT-I CTL were adoptively transferred to C57BL/6 mice 21 – 28 days prior to tumor challenge. At this time, the donor cells had the phenotypical and functional characteristics of memory CD8+ T cells. Recipients which developed tumor despite adoptive immunotherapy were analyzed to evaluate the reason(s) for therapeutic failure. RESULTS: Dose-response studies demonstrated that the degree of tumor protection was directly proportional to the number of OT-I CTL adoptively transferred. At a low dose of OT-I CTL, therapeutic failure was attributed to insufficient numbers of OT-I T cells that persisted in vivo, rather than mechanisms that actively suppressed or anergized the OT-I T cells. In recipients of high numbers of OT-I CTL, the E.G7 tumor that developed was shown to be resistant to fresh OT-I CTL when examined ex vivo. Furthermore, these same tumor cells no longer secreted a detectable level of OVA. In this case, resistance to immunotherapy was secondary to selection of clones of E.G7 that expressed a lower level of tumor antigen. CONCLUSIONS: Memory engraftment with tumor-specific CTL provides long-term protection against tumor. However, there are several limitations to this immunotherapeutic strategy, especially when targeting a single antigen. This study illustrates the importance of administering large numbers of effectors to engraft sufficiently efficacious immunologic memory. It also demonstrates the importance of targeting several antigens when developing vaccine strategies for cancer
Continuation for thin film hydrodynamics and related scalar problems
This chapter illustrates how to apply continuation techniques in the analysis
of a particular class of nonlinear kinetic equations that describe the time
evolution through transport equations for a single scalar field like a
densities or interface profiles of various types. We first systematically
introduce these equations as gradient dynamics combining mass-conserving and
nonmass-conserving fluxes followed by a discussion of nonvariational amendmends
and a brief introduction to their analysis by numerical continuation. The
approach is first applied to a number of common examples of variational
equations, namely, Allen-Cahn- and Cahn-Hilliard-type equations including
certain thin-film equations for partially wetting liquids on homogeneous and
heterogeneous substrates as well as Swift-Hohenberg and Phase-Field-Crystal
equations. Second we consider nonvariational examples as the
Kuramoto-Sivashinsky equation, convective Allen-Cahn and Cahn-Hilliard
equations and thin-film equations describing stationary sliding drops and a
transversal front instability in a dip-coating. Through the different examples
we illustrate how to employ the numerical tools provided by the packages
auto07p and pde2path to determine steady, stationary and time-periodic
solutions in one and two dimensions and the resulting bifurcation diagrams. The
incorporation of boundary conditions and integral side conditions is also
discussed as well as problem-specific implementation issues
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