CRITICAL ISSUES OF PAPILLOMA VIRUS INFECTION PREVENTION

The article details the issue of malignancy caused by human papilloma virus (HPV), as well as characteristics of this virus. Its genetic stability allows for efficient prevention of this pathology through vaccination. 2 vaccines, which are approved by the FDA end EMEA for use and are registered in Russia, have been created and are successfully used for this purpose. The authors believe that the best results may be achieved by combining screening examination programmes with universal reasonable administration of scheduled voluntary vaccination of Russia’s population.Key words: human papilloma virus, HPV infection, cervical cancer, malignancies, prevention, vaccination

CERVICAL CANCER IS NOT A CHILDREN'S ILLNESS, ISN'T IT?

The authors highlight the foreign authors review about the spread and peculiarities of the HPV infection and HPV'associated uterine cervix impairment in teenage girls. The interaction between HPV infection and uterine cervix impairment were described. There are also the most important prevention approaches in this issue. Key words: human papilloma virus, uterine cervix impairment, cervical cancer, screening, vaccination, teenage girls

CERVICAL CANCER IS NOT A CHILDREN'S ILLNESS, ISN'T IT?

The authors highlight the foreign authors review about the spread and peculiarities of the HPV infection and HPV'associated uterine cervix impairment in teenage girls. The interaction between HPV infection and uterine cervix impairment were described. There are also the most important prevention approaches in this issue. Key words: human papilloma virus, uterine cervix impairment, cervical cancer, screening, vaccination, teenage girls

CRITICAL ISSUES OF PAPILLOMA VIRUS INFECTION PREVENTION

The article details the issue of malignancy caused by human papilloma virus (HPV), as well as characteristics of this virus. Its genetic stability allows for efficient prevention of this pathology through vaccination. 2 vaccines, which are approved by the FDA end EMEA for use and are registered in Russia, have been created and are successfully used for this purpose. The authors believe that the best results may be achieved by combining screening examination programmes with universal reasonable administration of scheduled voluntary vaccination of Russia’s population.Key words: human papilloma virus, HPV infection, cervical cancer, malignancies, prevention, vaccination

РАК ШЕЙКИ МАТКИ - НЕ ДЕТСКАЯ БОЛЕЗНЬ

The authors highlight the foreign authors review about the spread and peculiarities of the HPV infection and HPV'associated uterine cervix impairment in teenage girls. The interaction between HPV infection and uterine cervix impairment were described. There are also the most important prevention approaches in this issue. Key words: human papilloma virus, uterine cervix impairment, cervical cancer, screening, vaccination, teenage girls.В статье изложены систематизированные данные зарубежных авторов, касающиеся распространенности и особенностей естественного течения ВПЧ-инфекции и ВПЧ-ассоциированных поражений шейки матки у девочек-подростков. Представлена взаимосвязь ВПЧ-инфекции и поражений шейки матки с рисковым поведением подростков; приведены наиболее важные направления их профилактики.Ключевые слова: вирус папилломы человека, девочки-подростки, рисковое поведение, интраэпителиальные поражения низкой степени (LSIL), интраэпителиальные поражения высокой степени (HSIL), рак шейки матки, скрининг, вакцинация. (Педиатрическая фармакология 2009;6(3):29-35)

АКТУАЛЬНЫЕ ВОПРОСЫ ПРОФИЛАКТИКИ ПАПИЛЛОМАВИРУСНОЙ ИНФЕКЦИИ

The article details the issue of malignancy caused by human papilloma virus (HPV), as well as characteristics of this virus. Its genetic stability allows for efficient prevention of this pathology through vaccination. 2 vaccines, which are approved by the FDA end EMEA for use and are registered in Russia, have been created and are successfully used for this purpose. The authors believe that the best results may be achieved by combining screening examination programmes with universal reasonable administration of scheduled voluntary vaccination of Russia’s population.Key words: human papilloma virus, HPV infection, cervical cancer, malignancies, prevention, vaccination.В статье подробно освещаются проблемы злокачественных новообразований, вызванных вирусом папилломы человека (ВПЧ), а также свойства самого вируса. Его генетическая стабильность обеспечивает возможность эффективной профилактики данной патологии путем вакцинации. Для этой цели уже созданы и успешно применяются 2 вакцины, которые одобрены к применению FDA, ЕМЕА и зарегистрированы в России. Авторы считают, что наилучших результатов можно достичь сочетанием скрининговых программ обследования с повсеместной разумной организацией плановой добровольной вакцинации населения России.Ключевые слова: вирус папилломы человека, ВПЧ-инфекция, рак шейки матки, злокачественные новообразования, профилактика, вакцинация.(Педиатрическая фармакология 2011;8(1):17-21

Inositols: pharmacology and findings of clinical trials. Current evidence and prospects

Yu.E. Dobrokhotova1, O.A. Gromova2, A.S. Dukhanin1, Z.Kh. Kumykova3, E.V. Sheremetyeva4, G.I. Tabeeva3 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2Federal Research Center "Informatics and Management" of the Russian Academy of Sciences, Moscow, Russian Federation 3V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation 4National Medical Research Center of Endocrinology, Moscow, Russian Federation Alterations in reproductive functions are associated with metabolic disorders, eating habits and lifestyle. In this context, a growing body of research is currently focused on the use of various vitamins and vitamin-like substances, such as inositol, in female patients with alterations in reproductive functions and metabolic disorders. Co-administration of inositol with pathogenetic therapy can be recommended to women of reproductive age with metabolic syndrome, as an additional option for preserving fertility and activating ovarian functions in young female patients with diminished ovarian reserve. Myoinositol and D-chiroinositol are inositol stereoisomers demonstrating the highest metabolic activity. The beneficial ratio of Myoinositol (MI) to D-chiroinositol (DCI) ensures the healthy state of organs and tissues, while a misbalance or depletion of inositol levels can cause various diseases. Combination of MI and DCI in a 5:1 ratio with manganese and folic acid is an&nbsp; original non-hormonal formula designed to improve functional state of the female reproductive system as well as carbohydrate and lipid metabolism. In addition, this combination should be considered as a promising alternative for the management of metabolic disorders in perimenopausal women. Keywords: reproductive function, metabolism, inositol, myoinositol, D-chiroinositol, polycystic ovary syndrome, ovarian reserve, menopause, metabolic syndrome, manganese, folic acid. For citation: Dobrokhotova Yu.E., Gromova O.A., Dukhanin A.S. et al. Inositols: pharmacology and findings of clinical trials. Current evidence and prospects. Russian Journal of Woman and Child Health. 2022;5(4):309–319 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-309-319. <br