Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain

published_or_final_versio

A two-year randomized clinical trial of chlorhexidine varnish on dental caries in Chinese preschool children

The objective of this study was to assess the effect of six-monthly professional applications of chlorhexidine varnish on the prevention of dental caries in primary molars in Chinese preschool children. In a double-blinded, randomized, placebo-controlled clinical trial, 334 children aged 4-5 years were randomly divided into two groups. Children in the test group received six-monthly applications of a 40% chlorhexidine varnish, and the control children received a placebo varnish. Caries status of the children was assessed by two calibrated examiners at baseline and after 24 months, according to criteria recommended by the World Health Organization. The two-year mean caries increments in the test and the control group children were 1.0 and 1.6 decayed, missing, or filled molar surfaces (dmfs-molar), respectively, a 37.3% reduction (t test, p = 0.036). No side-effects were found. It was concluded that six-monthly applications of chlorhexidine varnish were effective in reducing the incidence of dental caries in primary molars.published_or_final_versio

Dynamics of ferroelectric nano cluster in BaTiO3 observed as a real time correlation between two soft X-ray laser pulses

We carry out a theoretical investigation to clarify the dynamic property of photo-created nano-sized ferroelectric cluster observed in the paraelectric BaTiO3 as a real time correlation of speckle pattern between two soft X-ray laser pulses, at just above the paraelectric-ferroelectric phase transition temperature. Based on a model with coupled soft X-ray photon and ferroelectric phonon mode, we study the time dependence of scattering probability by using a perturbative expansion approach. The cluster-associated phonon softening as well as central peak effects are well reproduced in the phonon spectral function via quantum Monte Carlo simulation. Besides, it is found that the time dependence of speckle correlation is determined by the relaxation dynamics of ferroelectric clusters. Near the transition point, cluster excitation is stable, leading to a long relaxation time. While, at high temperature, cluster structure is subject to the thermal fluctuation, ending up with a short relaxation time.Comment: 9 pages, 3 figure

Pseudo-unitary symmetry and the Gaussian pseudo-unitary ensemble of random matrices

Employing the currently discussed notion of pseudo-Hermiticity, we define a pseudo-unitary group. Further, we develop a random matrix theory which is invariant under such a group and call this ensemble of pseudo-Hermitian random matrices as the pseudo-unitary ensemble. We obtain exact results for the nearest-neighbour level spacing distribution for (2 X 2) PT-symmetric Hamiltonian matrices which has a novel form, s log (1/s) near zero spacing. This shows a level repulsion in marked distinction with an algebraic form in the Wigner surmise. We believe that this paves way for a description of varied phenomena in two-dimensional statistical mechanics, quantum chromodynamics, and so on.Comment: 9 pages, 2 figures, LaTeX, submitted to the Physical Review Letters on August 20, 200

Recording advances for neural prosthetics

An important challenge for neural prosthetics research is to record from populations of neurons over long periods of time, ideally for the lifetime of the patient. Two new advances toward this goal are described, the use of local field potentials (LFPs) and autonomously positioned recording electrodes. LFPs are the composite extracellular potential field from several hundreds of neurons around the electrode tip. LFP recordings can be maintained for longer periods of time than single cell recordings. We find that similar information can be decoded from LFP and spike recordings, with better performance for state decodes with LFPs and, depending on the area, equivalent or slightly less than equivalent performance for signaling the direction of planned movements. Movable electrodes in microdrives can be adjusted in the tissue to optimize recordings, but their movements must be automated to be a practical benefit to patients. We have developed automation algorithms and a meso-scale autonomous electrode testbed, and demonstrated that this system can autonomously isolate and maintain the recorded signal quality of single cells in the cortex of awake, behaving monkeys. These two advances show promise for developing very long term recording for neural prosthetic applications

J/ψJ/\psi normal and anomalous suppressions in a hadron and string cascade model

A mechanism for the effective dissociation of a $c\bar{c}$ pair in the colour electric field of strings is introduced into a hadron and string cascade model, i.e. JPCIAE, which is based on the LUND model, simulating ultra-relativistic nucleus - nucleus collisions. This new mechanism together with the known mechanism of nuclear absorption (both baryons and mesons) could reproduce fairly the data of the normal and anomalous $J/\psi$ suppressions in minimum bias pA, AB (with light projectile), and Pb + Pb collisions at 200 A GeV/c. However the impact parameter (E_T) dependence of the $J/\psi$ suppression factor, both, in S + U and Pb + Pb reactions at 200 A GeV/c and 158 A GeV/c, respectively, is not well reproduced. We also tested the additional mechanism of the energy degradation of leading particles, with which both, the normal and anomalous $J/\psi$ suppressions in minimum bias pA, AB, and Pb + Pb collisions and the E_T dependence of the $J/\psi$ suppression factor are better reproduced.Comment: 16 pages (RevTex), 6 ps-figures, to be published in J. Phys.

Central administration of C-x-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice

Aim To explore the roles of C-X-C chemokine receptor type 4 (CXCR4) in spinal processing of neuropathic pain at the central nervous system (CNS). Methods Peripheral neuropathic pain (PNP) induced by partial sciatic nerve ligation (pSNL) model was assessed in mice. Effects of a single intrathecal (central) administration of AMD3100 (intrathecal AMD3100), a CXCR4 antagonist, on pain behavior and pain-related spinal pathways and molecules in the L3-L5 spinal cord segment was studied compare to saline treatment. Results Rotarod test showed that intrathecal AMD3100 did not impair mice motor function. In pSNL-induced mice, intrathecal AMD3100 delayed the development of mechanical allodynia and reversed the established mechanical allodynia in a dose-dependent way. Moreover, intrathecal AMD3100 downregulated the activation of JNK1 and p38 pathways and the protein expression of p65 as assessed by western blotting. Real-time PCR test also demonstrated that substance P mRNA was decreased, while adrenomedullin and intercellular adhesion molecule mRNA was increased following AMD3100 treatment. Conclusion Our results suggest that central (spinal) CXCR4 is involved in the development and maintenance of PNP and the regulation of multiple spinal molecular events under pain condition, implicating that CXCR4 would potentially be a therapeutic target for chronic neuropathic pain.published_or_final_versio

Gryphon M^3 system: integration of MEMS for flight control

By using distributed arrays of micro-actuators as effectors, micro-sensors to detect the optimal actuation location, and microelectronics to provide close loop feedback decisions, a low power control system has been developed for controlling a UAV. Implementing the Microsensors, Microactuators, and Microelectronics leads to what is known as a M^3 (M-cubic) system. This project involves demonstrating the concept of using small actuators (approximately micron-millimeter scale) to provide large control forces for a large-scale system (approximately meter scale) through natural flow amplification phenomenon. This is theorized by using fluid separation phenomenon, vortex evolution, and vortex symmetry on a delta wing aircraft. By using MEMS actuators to control leading edge vortex separation and growth, a desired aerodynamic force can be produced about the aircraft for flight control. Consequently, a MEMS shear stress sensor array was developed for detecting the leading edge separation line where leading edge vortex flow separation occurs. By knowing the leading edge separation line, a closely coupled micro actuation from the effectors can cause the required separation that leads to vortex control. A robust and flexible balloon type actuator was developed using pneumatic pressure as the actuation force. Recently, efforts have started to address the most elusive problem of amplified distributed control (ADC) through data mining algorithms. Preliminary data mining results are promising and this part of the research is ongoing. All wind tunnel data used the baseline 56.5 degree(s) sweepback delta wing with root chord of 31.75 cm