Thermoelasticity of Fe2+-bearing bridgmanite

We present LDA+U calculations of high temperature elastic properties of bridgmanite with composition (Mg$_{(1-x)}$Fe$_{x}^{2+}$)SiO$_3$ for $0\le{x}\le0.125$. Results of elastic moduli and acoustic velocities for the Mg-end member (x=0) agree very well with the latest high pressure and high temperature experimental measurements. In the iron-bearing system, we focus particularly on the change in thermoelastic parameters across the state change that occurs in ferrous iron above $\sim$30 GPa, often attributed to a high-spin (HS) to intermediate spin (IS) crossover but explained by first principles calculations as a lateral displacement of substitutional iron in the perovskite cage. We show that the measured effect of this change on the equation of state of this system can be explained by the lateral displacement of substitutional iron, not by the HS to IS crossover. The calculated elastic properties of (Mg$_{0.875}$Fe$_{0.125}^{2+}$)SiO$_3$ along an adiabatic mantle geotherm, somewhat overestimate longitudinal velocities but produce densities and shear velocities quite consistent with Preliminary Reference Earth Model data throughout most of the lower mantle.Comment: Accepted for Geophysical Research Letters (DOI: 10.1002/2014GL062888

Probabilistic Fragmentation and Effective Power Law

A simple fragmentation model is introduced and analysed. We show that, under very general conditions, an effective power law for the mass distribution arises with realistic exponent. This exponent has a universal limit, but in practice the effective exponent depends on the detailed breaking mechanism and the initial conditions. This dependence is in good agreement with experimental results of fragmentation.Comment: 4 pages Revtex, 2 figures, zipped and uuencode

Quantum criticality as a resource for quantum estimation

We address quantum critical systems as a resource in quantum estimation and derive the ultimate quantum limits to the precision of any estimator of the coupling parameters. In particular, if L denotes the size of a system and \lambda is the relevant coupling parameters driving a quantum phase transition, we show that a precision improvement of order 1/L may be achieved in the estimation of \lambda at the critical point compared to the non-critical case. We show that analogue results hold for temperature estimation in classical phase transitions. Results are illustrated by means of a specific example involving a fermion tight-binding model with pair creation (BCS model).Comment: 7 pages. Revised and extended version. Gained one author and a specific exampl

17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle

Rationale & Aim: Estrogen and estrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of HCV life cycle is/are affected by estrogens. Methods: Huh7 cells infected with the JFH1 virus (genotype 2a) were exposed to dehydroepiandrosterone, testosterone, progesterone and 17β-estradiol (tested with/without its receptor antagonist fulvestrant). Dose-response curves were established to calculate IC50 values. To dissect how 17β-estradiol interferes with phases of HCV life cycle, its effects were measured on the HCV pseudo-particle system (viral entry), the sub-genomic replicon N17/JFH1 and the replicon cell line Huh7-J17 (viral replication). Finally, in a dual-step infection model, infectious supernatants, collected from infected cells exposed to hormones, were used to infect naïve cells. Results: Progesterone and testosterone showed no inhibitory effect on HCV; dehydroepiandrosterone was only mildly inhibitory. In contrast, 17β-estradiol inhibited infection by 64-67% (IC50 values 140 to 160 nM). Fulvestrant reverted the inhibition by 17β-estradiol in a dose-dependent manner. 17β-estradiol exerted only a slight inhibition (<20%) on HCV pseudo-particles, and had no effect on cells either transiently or stably (Huh7-J17 cells) expressing the N17/JFH1 replicon. In the dual-step infection model, a significant IC50 decline occurred between primary (134 nM) and secondary (100 nM) infections (p=0.02), with extracellular HCV RNA and infectivity being reduced to a higher degree in comparison to its intracellular counterpart. Conclusions: 17β-estradiol inhibits HCV acting through its intracellular receptors, mainly interfering with late phases (assembly/release) of the HCV life cycle

Exploring complex networks via topological embedding on surfaces

We demonstrate that graphs embedded on surfaces are a powerful and practical tool to generate, characterize and simulate networks with a broad range of properties. Remarkably, the study of topologically embedded graphs is non-restrictive because any network can be embedded on a surface with sufficiently high genus. The local properties of the network are affected by the surface genus which, for example, produces significant changes in the degree distribution and in the clustering coefficient. The global properties of the graph are also strongly affected by the surface genus which is constraining the degree of interwoveness, changing the scaling properties from large-world-kind (small genus) to small- and ultra-small-world-kind (large genus). Two elementary moves allow the exploration of all networks embeddable on a given surface and naturally introduce a tool to develop a statistical mechanics description. Within such a framework, we study the properties of topologically-embedded graphs at high and low `temperatures' observing the formation of increasingly regular structures by cooling the system. We show that the cooling dynamics is strongly affected by the surface genus with the manifestation of a glassy-like freezing transitions occurring when the amount of topological disorder is low.Comment: 18 pages, 7 figure

Angular momentum effects in Michelson-Morley type experiments

The effect of the angular momentum density of a gravitational source on the times of flight of light rays in an interferometer is analyzed. The calculation is made imagining that the interferometer is at the equator of the gravity source and, as long as possible, the metric, provided it is stationary and axisymmetric, is not approximated. Finally, in order to evaluate the size of the effect in the case of the Earth a weak field approximation is introduced. For laboratory scales and non-geodesic paths the correction turns out to be comparable with the sensitivity expected in gravitational waves interferometric detectors, whereas it drops under the threshold of detectability when using free (geodesic) light rays.Comment: 12 pages, LaTeX; more about the detection technique, references added; accepted for publication in GR

Extended DFT+U+V method with on-site and inter-site electronic interactions

In this article we introduce a generalization of the popular DFT+U method based on the extended Hubbard model that includes on-site and inter-site electronic interactions. The novel corrective Hamiltonian is designed to study systems for which electrons are not completely localized on atomic states (according to the general scheme of Mott localization) and hybridization between orbitals from different sites plays an important role. The application of the extended functional to archetypal Mott - charge-transfer (NiO) and covalently bonded insulators (Si and GaAs) demonstrates its accuracy and versatility and the possibility to obtain a unifying and equally accurate description for a broad range of very diverse systems

Quantum estimation via minimum Kullback entropy principle

We address quantum estimation in situations where one has at disposal data from the measurement of an incomplete set of observables and some a priori information on the state itself. By expressing the a priori information in terms of a bias toward a given state the problem may be faced by minimizing the quantum relative entropy (Kullback entropy) with the constraint of reproducing the data. We exploit the resulting minimum Kullback entropy principle for the estimation of a quantum state from the measurement of a single observable, either from the sole mean value or from the complete probability distribution, and apply it as a tool for the estimation of weak Hamiltonian processes. Qubit and harmonic oscillator systems are analyzed in some details.Comment: 7 pages, slightly revised version, no figure