35,590 research outputs found
Short-time critical dynamics at perfect and non-perfect surface
We report Monte Carlo simulations of critical dynamics far from equilibrium
on a perfect and non-perfect surface in the 3d Ising model. For an ordered
initial state, the dynamic relaxation of the surface magnetization, the line
magnetization of the defect line, and the corresponding susceptibilities and
appropriate cumulant is carefully examined at the ordinary, special and surface
phase transitions. The universal dynamic scaling behavior including a dynamic
crossover scaling form is identified. The exponent of the surface
magnetization and of the line magnetization are extracted. The impact
of the defect line on the surface universality classes is investigated.Comment: 11figure
Dynamic Monte Carlo Study of the Two-Dimensional Quantum XY Model
We present a dynamic Monte Carlo study of the Kosterlitz-Thouless phase
transition for the spin-1/2 quantum XY model in two dimensions. The short-time
dynamic scaling behaviour is found and the dynamical exponent , and
the static exponent are determined at the transition temperature.Comment: 6 pages with 3 figure
Analyticity and the counting rule of matrix poles
By studying scattering amplitudes in the large limit, we
clarify the dependence of the matrix pole position. It is
demonstrated that analyticity and the counting rule exclude the existence
of matrix poles with . Especially the properties
of and with respect to the expansion are discussed.
We point out that in general tetra-quark resonances do not exist.Comment: This paper replaces hep-ph/0412175. The latter is withdraw
The principle of least action and the geometric basis of D-branes
We analyze thoroughly the boundary conditions allowed in classical non-linear
sigma models and derive from first principle the corresponding geometric
objects, i.e. D-branes. In addition to giving classical D-branes an intrinsic
and geometric foundation, D-branes in nontrivial H flux and D-branes embedded
within D-branes are precisely defined. A well known topological condition on
D-branes is replaced
Measurement of the c-axis optical reflectance of AFeAs (A=Ba, Sr) single crystals: Evidence of different mechanisms for the formation of two energy gaps
We present the c-axis optical reflectance measurement on single crystals of
BaFeAs and SrFeAs, the parent compounds of FeAs based
superconductors. Different from the ab-plane optical response where two
distinct energy gaps were observed in the SDW state, only the smaller energy
gap could be seen clearly for \textbf{E}c-axis. The very pronounced
energy gap structure seen at a higher energy scale for
\textbf{E}ab-plane is almost invisible. We propose a novel picture
for the band structure evolution across the SDW transition and suggest
different driving mechanisms for the formation of the two energy gaps.Comment: 4 page
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
BACKGROUND: Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood. METHODS: BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis. The virus-infected mice were treated with the CC chemokine antagonist Met-RANTES or anti-RANTES mAb to determine the role of RANTES in affecting TBEV-induced neurological disease. The underlying signaling mechanisms were delineated using RANTES promoter luciferase reporter assay, siRNA-mediated knockdown, and pharmacological inhibitors in human brain-derived cell culture models. RESULTS: In a mouse model, pathological features including marked inflammatory cell infiltrates were observed in brain sections, which correlated with a robust up-regulation of RANTES within the brain but not in peripheral tissues and sera. Antagonizing RANTES within CNS extended the survival of mice and reduced accumulation of infiltrating cells in the brain after TBEV infection. Through in vitro studies, we show that virus infection up-regulated RANTES production at both mRNA and protein levels in human brain-derived cell lines and primary progenitor-derived astrocytes. Furthermore, IRF-3 pathway appeared to be essential for TBEV-induced RANTES production. Site mutation of an IRF-3-binding motif abrogated the RANTES promoter activity in virus-infected brain cells. Moreover, IRF-3 was activated upon TBEV infection as evidenced by phosphorylation of TBK1 and IRF-3, while blockade of IRF-3 activation drastically reduced virus-induced RANTES expression. CONCLUSIONS: Our findings together provide insights into the molecular mechanism underlying RANTES production induced by TBEV, highlighting its potential importance in the process of neuroinflammatory responses to TBEV infection
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