24 research outputs found
The magnetocaloric effect and critical behavior in amorphous Gd 60Co 40-xMn x alloys.
The amorphous alloys Gd60Co40−xMnx (x = 0, 5, 10, 15) were prepared by melt spinning. The Curie temperature,T c, increases monotonously with Mn addition, ranging from 198 K for x = 0 to 205 K for x = 15, while the maximum values of −ΔSM under the applied field change from 0 to 5 T are 7.7, 7.1, 6.2 and 5.4 J·kg−1·K−1 for x = 0, 5, 10, and 15, respectively. All samples undergo a second order ferri-paramagnetic phase transition. The critical behavior around the transitiontemperature is investigated in detail, using both the standard Kouvel-Fisher procedure as well as the study of the field dependence of the magnetocaloric effect. Results indicate that the obtained critical exponents are reliable, and that the present alloys exhibit local magnetic interaction
Magnetic properties and magnetocaloric effects in GdCo9Si2 compound with multiple magnetic phase transitions
The structure and magnetic properties of polycrystalline GdCo9Si2 compound have been investigated. It has a BaCd11 structure and undergoes two magnetic phase transitions: an antiferromagnetic to ferrimagnetic transition occurring at rv93 K, and a ferrimagnetic to paramagnetic transition at 420 K, which results in a positive and a negative magnetic entropy change, respectively. The two peak values of magnetic entropy change are -0.6 and 1.1 J·kg-1 K-1 for DH ¼ 5 T. Furthermore, there exists a metal-semiconductor transition temperature (TP), below which the resistance increases with increasing temperature, while the semiconductor characteristic is observed above TP. The magnetic domain structures are characterized by stripe and grid structures 1 lm wide. Although the MCE is small for applications, its study is useful to clearly understand the nature of multiple magnetic phase transitions in the GdCo9Si2 compound
Low hysteresis and large room temperature magnetocaloric effect of Gd 5Si2.05-xGe1.95-xNi2x (2x 0.08, 0.1) alloys
Gd5Si2.05-xGe1.95-xNi2x (2x ¼ 0.08, 0.1) alloys were prepared by arc melting followed by annealing at 1273 K for 96 h. Mixed monoclinic Gd5Si2Ge2-type phase, orthorhombic Gd5Si4-type phase, and a small amount of Gd5Si3-type phase were obtained in these alloys. Gd5Si2.01Ge1.91Ni0.08 alloy undergoes a second-order transition (TC) around 300 K, whereas Gd5Si2Ge1.9Ni0.1 alloy exhibits two
II I transitions including a first-order transition (TC ) at rv295 K and second-order transition (TC ) at rv301 K. Ni substitution can effectively reduce the thermal hysteresis and magnetic hysteresis while
max maintaining large magnetic entropy change. The maximum magnetic entropy changes (|DSM |) of 1 -1
Gd5Si2.05-xGe1.95-xNi2x alloys with 2x ¼ 0.08 and 0.1 are 4.4 and 5.0 J kg- K, respectively, for 0–2 T, and are 8.0 and 9.1 J kg-1 K-1, respectively, for 0–5 T. Low hysteresis performance and relatively large magnetic entropy change make these alloys favorable for magnetic refrigeration applications
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
A Five-Gene Signature Based on Stromal/Immune Scores in the Tumor Microenvironment and Its Clinical Implications for Liver Cancer
Deterministic fabrication of nanostructures for plasmonic lens by focused ion beam
Plasmonic lens is a key component in the development of sub-wavelength resolution optical system for bio-imaging and nanolithography applications. In order to develop a deterministic fabrication capability for nanostructures on plasmonic lens by using focused ion beam, this paper presents a highly robust and accurate surface topography model based on level set method. Sputtered atom distribution and angular dependence of sputter yield are calculated by Monte Carlo simulation programs SRIM/TRIM and TRIDYN, respectively. Redeposition effect is included in the physical model and successfully embedded into a topography simulation program by applying the level set method. The proposed model is validated and evaluated in the focused ion beam fabrication experiments. Simulation error of less than 7% is obtained. Two types of nanostructures for plasmonic lens were fabricated using the machining parameters approved by this simulation model. Simulation errors of 7 and 2 nm were found in a nanodots array and a spiral Bragg grating, respectively. The results clearly demonstrate the effectiveness of the modelling approach developed for deterministic fabrication of nanostructure
An integrated system for ultra-precision machine tool design in conceptual and fundamental design stage
Investigation on the thermal effects during nanometric cutting process while using nanoscale diamond tools
In this paper, large scale molecular dynamics simulations are carried out to investigate the thermal effect on nanometric cutting of copper while using a single tip and a multi-tip nanoscale diamond tool. A new concept of atomistic equivalent temperature is proposed and used to characterize the temperature distribution in the cutting zone. The results show that the cutting heat generated while using a multi-tip tool is larger than that of using a single tip tool. The local temperature is found to be higher at the inner sides of the multi-tip tool cutting edges than the outer sides. Applying centro-symmetry parameters and radius distribution function, the local annealing process and its effect on the integrity of the machined nanostructures are analyzed. It is observed that the local annealing at the machined surface can improve the surface integrity of the machined nanostructures, especially in the multi-tip diamond tool cutting process. There exists a great potential to control the thickness of residual atomic defect layer through an optimal selection of the cutting speed with designed depth of cut