Distribution of Energy-Momentum in a Schwarzschild-Quintessence Space-time Geometry

An analysis of the energy-momentum localization for a four-dimensional\break Schwarzschild black hole surrounded by quintessence is presented in order to provide expressions for the distributions of energy and momentum. The calculations are performed by using the Landau-Lifshitz and Weinberg energy-momentum complexes. It is shown that all the momenta vanish, while the expression for the energy depends on the mass $M$ of the black hole, the state parameter $w_{q}$ and the normalization factor $c$. The special case of $w_{q}=-2/3$ is also studied, and two limiting cases are examined.Comment: 9 page

From the Sum of Near-Zero Energy Buildings to the Whole of a Near-Zero Energy Housing Settlement: The Role of Communal Spaces in Performance-Driven Design

Almost a century ago Modernism challenged the structure of the city and reshaped its physical space in order to, amongst other things, accommodate new transportation infrastructure and road networks proclaiming the,nowadays much-debated ‘scientificated’ pursuit of efficiency for the city. This transformation has had a great impact on the way humans still design, move in, occupy and experience the city. Today major cities in Europe, such as Paris and London, are considering banning vehicles from their historic centers. In parallel, significant effort is currently underway internationally by designers, architects, and engineers to integrate innovative technologies and sophisticated solutions for energy production, management, and storage, as well as for efficient energy consumption, into the architecture of buildings. In general, this effort seeks for new technologies and design methods (e.g., DesignBuilder with EnergyPlus simulation engine; Rhicoceros3D with Grasshopper plugin and Ecotect, Radiance and EnergyPlus tools) that would enable a holistic approach to the spatial design of Near-Zero Energy buildings, so that their ecological benefits are an added value to the architectural design and a building’s visual, and material, impact on its surrounding space. The paper inquires how the integration of such technological infrastructure and performance-orientated interfaces changes yet again the structure and form of cities, and to what extent it safeguards social rights and enables equal access to common resources. Drawing from preliminary results and initial considerations of ongoing research that involve the construction of four innovative NZE settlements across Europe, in the context of the EU-funded ZERO-PLUS project, this paper discusses the integration of novel infrastructure in communal spaces of these settlements. In doing so, it contributes to the debate about smart communities and their role in the sustainable management of housing developments and settlements that are designed and developed with the concept of smart territories

Rapid downregulation of innate immune cells, interleukin-12 and interleukin-23 in generalized pustular psoriasis with infliximab in combination with acitretin

Generalized pustular psoriasis (GPP) is a severe inflammatory disease characterized by recurrent eruptions of sterile pustules on erythematous skin. Although tumor necrosis factor (TNF) antagonists may lead to a rapid resolution of GPP, the mechanism of action of these agents remains to be investigated. Here, we sought to evaluate markers of immune response in the skin of a patient who experienced a rapid amelioration of GPP after treatment with infliximab and acitretin

Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes

In the present study, the effects of extracts and polyphenol-rich fractions as well as monomer polyphenols identified in them, from both red and white grapes, on mitomycin C (MMC) induced sister chromatid exchanges (SCEs) in human peripheral blood lymphocytes were investigated. The grape extracts and two of the three polyphenol-rich fractions promoted MMC-induced SCEs at concentrations from 75 to 300 μg/mL. However, none of the extracts or fractions alone induced SCEs. Thus, these results suggest caution especially with regard to the use of grape extracts as dietary supplements. On the other hand, the fact that these extracts were not genotoxic alone may indicate a selective activity against genetically damaged cells. This is the first study regarding the clastogenic effects of grape extracts in human cells. Moreover, from the tested polyphenols, caffeic acid, gallic acid, and rutin hydrate enhanced MMC-induced clastogenicity, whereas ferulic acid, protocatechuic acid, (+)-catechin, (-)-epicatechin, and trans-resveratrol had no effect at concentrations between 5 and 100 μM. The differences in the chemical structures of the tested polyphenols may account for their differential effects on MMC clastogenicity. © 2007 American Chemical Society

Differences in the efficiency between the grab and track starts for both genders in Greek young swimmers

The aim of this study was to determine the differences in the kinematic parameters between the grab and track starts and the differences in these two starts between genders. A total of 27 swimmers at the competitive level participated in the study, 13 boys (mean ± SD: age 15.8 ± 0.8 years, body mass 67.7 ± 7.7 kg and body height 178.6 ± 5.7 cm) and 14 girls (mean ± SD: age 16 ± 0.8 years, body mass 59.2 ± 6.6 kg and body height 166.2 ± 6.7 cm). Each swimmer performed three attempts for both start techniques. The best attempt of the grab start and the track start was taken for further analysis. The following kinematic parameters were analysed: flight distance, flight time, flight velocity, entry angle and reaction time. The males had greater numeric values for the results in all kinematic parameters for the grab start compared with the track start, except for flight velocity and entry angle (flight time 0.42 vs. 0.41 s, flight distance 3.21 vs. 3.14 m, flight velocity 7.76 vs. 7.83 m/s, entry angle 44.22 vs. 43.85 degrees and reaction time 0.86 vs. 0.81 s). The females also had greater numeric values for the results in all kinematic parameters for the grab start compared with the track start, except for flight time (flight time 0.38 vs. 0.38 s, flight distance 2.82 vs. 2.73 m, flight velocity 7.47 vs. 7.31 m/s, entry angle 45.18 vs. 44.79 degrees and reaction time 0.88 vs. 0.82 s). These results indicate that the males had significantly better results for flight time and flight distance compared with the females for the grab start (flight time 0.42 vs. 0.38 s, flight distance 3.21 vs. 2.82 m). In the case of the track start, the males had significantly better results for flight distance (3.14 vs. 2.73 m). Exploring the characteristics of the two starts did not lead to any significant kinematic differences. Therefore, a conclusion that demonstrates the superiority of one of the techniques cannot be reached. The coach, together with each swimmer individually, should devote some time to decide after some tests what type of start is better for the body type and general qualifications of the swimmer

Novel genetic risk variants for pediatric celiac disease

Background: Celiac disease is a complex chronic immune-mediated disorder of the small intestine. Today, the pathobiology of the disease is unclear, perplexing differential diagnosis, patient stratification, and decision-making in the clinic. Methods: Herein, we adopted a next-generation sequencing approach in a celiac disease trio of Greek descent to identify all genomic variants with the potential of celiac disease predisposition. Results: Analysis revealed six genomic variants of prime interest: SLC9A4 c.1919G>A, KIAA1109 c.2933T>C and c.4268-4269delCCinsTA, HoxB6 c.668C>A, HoxD12 c.418G>A, and NCK2 c.745-746delAAinsG, from which NCK2 c.745-746delAAinsG is novel. Data validation in pediatric celiac disease patients of Greek (n = 109) and Serbian (n = 73) descent and their healthy counterparts (n = 111 and n = 32, respectively) indicated that HoxD12 c.418G>A is more prevalent in celiac disease patients in the Serbian population (P < 0.01), while NCK2 c.745-746delAAinsG is less prevalent in celiac disease patients rather than healthy individuals of Greek descent (P = 0.03). SLC9A4 c.1919G>A and KIAA1109 c.2933T>C and c.4268-4269delCCinsTA were more abundant in patients; nevertheless, they failed to show statistical significance. Conclusions: The next-generation sequencing-based family genomics approach described herein may serve as a paradigm towards the identification of novel functional variants with the aim of understanding complex disease pathobiology. © 2016 The Author(s)