365 research outputs found
Comment on 'Note on the dog-and-rabbit chase problem in introductory kinematics'
We comment on the recent paper by Yuan Qing-Xin and Du Yin-Xiao (Eur. J.
Phys. 29 (2008) N43-N45).Comment: 2 pages, no figure
Sensitivity of various body indices and visceral adiposity index in predicting metabolic syndrome among Chinese patients with adult growth hormone deficiency
Rotational Symmetry of Classical Orbits, Arbitrary Quantization of Angular Momentum and the Role of Gauge Field in Two-Dimensional Space
We study the quantum-classical correspondence in terms of coherent wave
functions of a charged particle in two-dimensional central-scalar-potentials as
well as the gauge field of a magnetic flux in the sense that the probability
clouds of wave functions are well localized on classical orbits. For both
closed and open classical orbits, the non-integer angular-momentum quantization
with the level-space of angular momentum being greater or less than is
determined uniquely by the same rotational symmetry of classical orbits and
probability clouds of coherent wave functions, which is not necessarily
-periodic. The gauge potential of a magnetic flux impenetrable to the
particle cannot change the quantization rule but is able to shift the spectrum
of canonical angular momentum by a flux-dependent value, which results in a
common topological phase for all wave functions in the given model. The quantum
mechanical model of anyon proposed by Wilczek (Phys. Rev. Lette. 48, 1144)
becomes a special case of the arbitrary-quantization.Comment: 6 pages, 5 figure
Engineered Cytochrome c-Catalyzed Lactone-Carbene B–H Insertion
Previous work has demonstrated that variants of a heme protein, Rhodothermus marinus cytochrome c (Rma cyt c), catalyze abiological carbene boron–hydrogen (B–H) bond insertion with high efficiency and selectivity. Here we investigated this carbon–boron bond-forming chemistry with cyclic, lactone-based carbenes. Using directed evolution, we obtained a Rma cyt c variant BOR^(LAC) that shows high selectivity and efficiency for B–H insertion of 5- and 6-membered lactone carbenes (up to 24,500 total turnovers and 97.1:2.9 enantiomeric ratio). The enzyme shows low activity with a 7-membered lactone carbene. Computational studies revealed a highly twisted geometry of the 7-membered lactone carbene intermediate relative to 5- and 6-membered ones. Directed evolution of cytochrome c together with computational characterization of key iron-carbene intermediates has allowed us to expand the scope of enzymatic carbene B–H insertion to produce new lactone-based organoborons
Parallel momentum distribution of the Si fragments from P
Distribution of the parallel momentum of Si fragments from the breakup
of 30.7 MeV/nucleon P has been measured on C targets. The distribution
has the FWHM with the value of 110.5 23.5 MeV/c which is consistent
quantitatively with Galuber model calculation assuming by a valence proton in
P. The density distribution is also predicted by Skyrme-Hartree-Fock
calculation. Results show that there might exist the proton-skin structure in
P.Comment: 4 pages, 4 figure
Engineered Cytochrome c-Catalyzed Lactone-Carbene B–H Insertion
Previous work has demonstrated that variants of a heme protein, Rhodothermus marinus cytochrome c (Rma cyt c), catalyze abiological carbene boron–hydrogen (B–H) bond insertion with high efficiency and selectivity. Here we investigated this carbon–boron bond-forming chemistry with cyclic, lactone-based carbenes. Using directed evolution, we obtained a Rma cyt c variant BOR^(LAC) that shows high selectivity and efficiency for B–H insertion of 5- and 6-membered lactone carbenes (up to 24,500 total turnovers and 97.1:2.9 enantiomeric ratio). The enzyme shows low activity with a 7-membered lactone carbene. Computational studies revealed a highly twisted geometry of the 7-membered lactone carbene intermediate relative to 5- and 6-membered ones. Directed evolution of cytochrome c together with computational characterization of key iron-carbene intermediates has allowed us to expand the scope of enzymatic carbene B–H insertion to produce new lactone-based organoborons
Multiparty hierarchical quantum-information splitting
We propose a scheme for multiparty hierarchical quantum-information splitting
(QIS) with a multipartite entangled state, where a boss distributes a secret
quantum state to two grades of agents asymmetrically. The agents who belong to
different grades have different authorities for recovering boss's secret.
Except for boss's Bell-state measurement, no nonlocal operation is involved.
The presented scheme is also shown to be secure against eavesdropping. Such a
hierarchical QIS is expected to find useful applications in the field of modern
multipartite quantum cryptography.Comment: 6 pages, 2 table
The accretion flow geometry of MAXI J1820+070 through broadband noise research with Insight-HXMT
Here we present a detailed study of the broadband noise in the power density
spectra of the black hole X-ray binary MAXI J1820+070 during the hard state of
its 2018 outburst, using the Hard X-ray Modulation Telescope (Insight-HXMT)
observations. The broadband noise shows two main humps, which might separately
correspond to variability from a variable disk and two Comptonization regions.
We fitted the two humps with multiple Lorentzian functions and studied the
energy-dependent properties of each component up to 100--150 keV and their
evolution with spectral changes. The lowest frequency component is considered
as the sub-harmonic of QPO component and shows different energy dependence
compared with other broadband noise components. We found that although the
fractional rms of all the broadband noise components mainly decrease with
energy, their rms spectra are different in shape. Above 20--30 keV, the
characteristic frequencies of these components increase sharply with energy,
meaning that the high-energy component is more variable on short timescales.
Our results suggest that the hot inner flow in MAXI J1820+070 is likely to be
inhomogeneous. We propose a geometry with a truncated accretion disk, two
Comptonization regions
High-Level Expression of Notch1 Increased the Risk of Metastasis in T1 Stage Clear Cell Renal Cell Carcinoma
Background: Although metastasis of clear cell renal cell carcinoma (ccRCC) is basically observed in late stage tumors, T1 stage metastasis of ccRCC can also be found with no definite molecular cause resulting inappropriate selection of surgery method and poor prognosis. Notch signaling is a conserved, widely expressed signal pathway that mediates various cellular processes in normal development and tumorigenesis. This study aims to explore the potential role and mechanism of Notch signaling in the metastasis of T1 stage ccRCC. Methodology/Principal Findings: The expression of Notch1 and Jagged1 were analyzed in tumor tissues and matched normal adjacent tissues obtained from 51 ccRCC patients. Compared to non-tumor tissues, Notch1 and Jagged1 expression was significantly elevated both in mRNA and protein levels in tumors. Tissue samples of localized and metastatic tumors were divided into three groups based on their tumor stages and the relative mRNA expression of Notch1 and Jagged1 were analyzed. Compared to localized tumors, Notch1 expression was significantly elevated in metastatic tumors in T1 stage while Jagged1 expression was not statistically different between localized and metastatic tumors of all stages. The average size of metastatic tumors was significantly larger than localized tumors in T1 stage ccRCC and the elevated expression of Notch1 was significantly positive correlated with the tumor diameter. The functional significance of Notch signaling was studied by transfection of 786-O, Caki-1 and HKC cell lines with full-length expression plasmids of Notch1 and Jagged1
IDN2 and Its Paralogs Form a Complex Required for RNA–Directed DNA Methylation
IDN2/RDM12 has been previously identified as a component of the RNA–directed DNA methylation (RdDM) machinery in Arabidopsis thaliana, but how it functions in RdDM remains unknown. By affinity purification of IDN2, we co-purified two IDN2 paralogs IDP1 and IDP2 (IDN2 PARALOG 1 and 2). The coiled-coil domain between the XS and XH domains of IDN2 is essential for IDN2 homodimerization, whereas the IDN2 C-terminal XH domain but not the coiled-coil domain is required for IDN2 interaction with IDP1 and IDP2. By introducing the wild-type IDN2 sequence and its mutated derivatives into the idn2 mutant for complementation testing, we demonstrated that the previously uncharacterized IDN2 XH domain is required for the IDN2-IDP1/IDP2 complex formation as well as for IDN2 function. IDP1 is required for de novo DNA methylation, siRNA accumulation, and transcriptional gene silencing, whereas IDP2 has partially overlapping roles with IDP1. Unlike IDN2, IDP1 and IDP2 are incapable of binding double-stranded RNA, suggesting that the roles of IDP1 and IDP2 are different from those of IDN2 in the IDN2-IDP1/IDP2 complex and that IDP1 and IDP2 are essential for the functioning of the complex in RdDM
- …