Measuring the metastatic potential of cancer cells

Cancer cells must secrete proteolytic enzymes to invade adjacent tissues and migrate to a new metastatic site. Urokinase (uPA) is a key enzyme related to metastasis in cancers of the lung, colon, gastric, uterine, breast, brain, and malignant melanoma. A NASA technology utilization project has combined fluorescence microscopy, image analysis, and flow cytometry, using fluorescent dyes, and urokinase-specific antibodies to measure uPA and abnormal DNA levels (related to cancer cell proliferation) inside the cancer cells. The project is focused on developing quantitative measurements to determine if a patient's tumor cells are actively metastasizing. If a significant number of tumor cells contain large amounts of uPA (esp. membrane-bound) then the post-surgical chemotherapy or radiotherapy can be targeted for metastatic cells that have already left the primary tumor. These analytical methods have been applied to a retrospective study of biopsy tissues from 150 node negative, stage 1 breast cancer patients. Cytopathology and image analysis has shown that uPA is present in high levels in many breast cancer cells, but not found in normal breast. Significant amounts of uPA also have been measured in glioma cell lines cultured from brain tumors. Commercial applications include new diagnostic tests for metastatic cells, in different cancers, which are being developed with a company that provides a medical testing service using flow cytometry for DNA analysis and hormone receptors on tumor cells from patient biopsies. This research also may provide the basis for developing a new 'magic bullet' treatment against metastasis using chemotherapeutic drugs or radioisotopes attached to urokinase-specific monoclonal antibodies that will only bind to metastatic cells

Observation of Enhanced Beaming from Photonic Crystal Waveguides

We report on the experimental observation of the beaming effect in photonic crystals enhanced via surface modes. We experimentally map the spatial field distribution of energy emitted from a subwavelength photonic crystal waveguide into free-space, rendering with crisp clarity the diffractionless beaming of energy. Our experimental data agree well with our numerical studies of the beaming enhancement in photonic crystals with modulated surfaces. Without loss of generality, we study the beaming effect in a photonic crystal scaled to microwave frequencies and demonstrate the technological capacity to deliver long-range, wavelength-scaled beaming of energy.Comment: 4 pages, 6 figure

Are simulated aerosol-induced effects on deep convective clouds strongly dependent on saturation adjustment?

Three configurations of a bulk microphysics scheme in conjunction with a detailed bin scheme are implemented in the Weather Research and Forecasting (WRF) model to specifically address the role of the saturation adjustment assumption (i.e., condensing/evaporating the surplus/deficit water vapor relative to saturation in one time step) on aerosol-induced invigoration of deep convective clouds. The bulk model configurations are designed to treat cloud droplet condensation/evaporation using either saturation adjustment, as employed in most bulk models, or an explicit representation of supersaturation over a time step, as used in bin models. Results demonstrate that the use of saturation adjustment artificially enhances condensation and latent heating at low levels and limits the potential for an increase in aerosol concentration to increase buoyancy at mid to upper levels. This leads to a small weakening of the time- and domain-averaged convective mass flux (~-3%) in polluted compared to clean conditions. In contrast, the bin model and bulk scheme with explicit prediction of supersaturation simulate an increase in latent heating aloft and the convective updraft mass flux is weakly invigorated (~5%). The bin model also produces a large increase in domain-mean cumulative surface precipitation in polluted conditions (~18%), while all of the bulk model configurations simulate little change in precipitation. Finally, it is shown that the cold pool weakens substantially with increased aerosol loading when saturation adjustment is applied, which acts to reduce the low-level convergence and weaken the convective dynamics. With an explicit treatment of supersaturation in the bulk and bin models there is little change in cold pool strength, so that the convective response to polluted conditions is influenced more by changes in latent heating aloft. It is concluded that the use of saturation adjustment can explain differences in the response of cold pool evolution and convective dynamics with aerosol loading simulated by the bulk and bin models, but cannot explain large differences in the response of surface precipitation between these models

Scalable squeezed light source for continuous variable quantum sampling

We propose a novel squeezed light source capable of meeting the stringent requirements of continuous variable quantum sampling. Using the effective $\chi_2$ interaction induced by a strong driving beam in the presence of the $\chi_3$ response in an integrated microresonator, our device is compatible with established nanophotonic fabrication platforms. With typical realistic parameters, squeezed states with a mean photon number of 10 or higher can be generated in a single consistent temporal mode at repetition rates in excess of 100MHz. Over 15dB of squeezing is achievable in existing ultra-low loss platforms

Type IIB Orientifolds with NS-NS Antisymmetric Tensor Backgrounds

We consider six dimensional N=1 space-time supersymmetric Type IIB orientifolds with non-zero untwisted NS-NS sector B-field. The B-field is quantized due to the requirement that the Type IIB spectrum be left-right symmetric. The presence of the B-field results in rank reduction of both 99 and 55 open string sector gauge groups. We point out that in some of the models with non-zero B-field there are extra tensor multiplets in the Z_2 twisted closed string sector, and we explain their origin in a simple example. Also, the 59 open string sector states come with a multiplicity that depends on the B-field. These two facts are in accord with anomaly cancellation requirements. We point out relations between various orientifolds with and without the B-field, and also discuss the F-theory duals of these models.Comment: 13 pages, revtex, minor misprints correcte

Dissipation-driven quantum phase transitions in collective spin systems

We consider two different collective spin systems subjected to strong dissipation -- on the same scale as interaction strengths and external fields -- and show that either continuous or discontinuous dissipative quantum phase transitions can occur as the dissipation strength is varied. First, we consider a well known model of cooperative resonance fluorescence that can exhibit a second-order quantum phase transition, and analyze the entanglement properties near the critical point. Next, we examine a dissipative version of the Lipkin-Meshkov-Glick interacting collective spin model, where we find that either first- or second-order quantum phase transitions can occur, depending only on the ratio of the interaction and external field parameters. We give detailed results and interpretation for the steady state entanglement in the vicinity of the critical point, where it reaches a maximum. For the first-order transition we find that the semiclassical steady states exhibit a region of bistability.Comment: 12 pages, 16 figures, removed section on homodyne spectr

Distinguishing left- and right-handed molecules by two-step coherent pulses

Chiral molecules with broken parity symmetries can be modeled as quantum systems with cyclic-transition structures. By using these novel properties, we design two-step laser pulses to distinguish left- and right-handed molecules from the enantiomers. After the applied pulse drivings, one kind chiral molecules are trapped in coherent population trapping state, while the other ones are pumped to the highest states for ionizations. Then, different chiral molecules can be separated.Comment: 11 pages, 3 figures

Collimation of Highly Variable Magnetohydrodynamic Disturbances around a Rotating Black Hole

We have studied non-stationary and non-axisymmetric perturbations of a magnetohydrodynamic accretion onto a rotating (Kerr) black hole. Assuming that the magnetic field dominates the plasma accretion, we find that the accretion suffers a large radial acceleration resulting from the Lorentz force, and becomes highly variable compared with the electromagnetic field there. In fact, we further find an interesting perturbed structure of the plasma velocity with a large peak in some narrow region located slightly inside of the fast-magnetosonic surface. This is due to the concentrated propagation of the fluid disturbances in the form of fast-magnetosonic waves along the separatrix surface. If the fast-magnetosonic speed is smaller in the polar regions than in the equatorial regions, the critical surface has a prolate shape for radial poloidal field lines. In this case, only the waves that propagate towards the equator can escape from the super-fast-magnetosonic region and collimate polewards as they propagate outwards in the sub-fast-magnetosonic regions. We further discuss the capabilities of such collimated waves in accelerating particles due to cyclotron resonance in an electron-positron plasma.Comment: 15 pages, 6 postscript figures, LaTe