12 research outputs found
From tension to compression: Asymmetric mechanical behaviour of trabecular bone's organic phase
Juvenile bovine bone is an appropriate surrogate for normal and reduced density human bone in biomechanical testing: a validation study
Histological determination of the human origin from dry bone: a cautionary note for subadults
Immune Reconstitution Kinetics following Intentionally Induced Mixed Chimerism by Nonmyeloablative Transplantation
Immune tolerance in recipients of combined haploidentical bone marrow and kidney transplantation
Fuel consumption patterns, price trends and prospects for Britain
Difficulties inhibiting inter-fuel substitutions will mean that oil will remain the pace setter for unit energy prices, at least until AD 2010. Because of our over-dependence on this depleting resource, the overall upward trend of unit prices for all fuels, as experienced during the previous decade, will continue, despite short-term falls. However, the price mechanism alone appears to be too blunt an instrument to ensure the rational use of energy.
The complementary roles of deletion and regulation in transplantation tolerance
Neonatal tolerance of alloantigens was described in mice nearly half a century ago, but unfortunately, the translation of these early findings into the clinical arena proved to be much more challenging than was first anticipated. However, the past decade has seen considerable progress in our understanding of the mechanisms that contribute to transplantation tolerance in experimental models. This review outlines our current understanding of the mechanisms of allograft tolerance, emphasizing the complementary roles of deletion and regulation of alloreactive T cells
The emerging role of ADAM metalloproteinases in immunity
Proteolysis is an irreversible physiological process that can result in the termination or activation of protein function. Many transmembrane proteins that are involved in the cellular communication between immune cells and structural cells-for example, Notch, CD23, CD44, and membrane-anchored cytokines and their receptors-are cleaved by the ADAM (a disintegrin and metalloproteinase) family of enzymes. Here, we review recent insights into the molecular activation, substrate specificity and function of ADAM proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17