AdS Duals of Matrix Strings

We review recent work on the holographic duals of type II and heterotic matrix string theories described by warped AdS_3 supergravities. In particular, we compute the spectra of Kaluza-Klein primaries for type I, II supergravities on warped AdS_3xS^7 and match them with the primary operators in the dual two-dimensional gauge theories. The presence of non-trivial warp factors and dilaton profiles requires a modification of the familiar dictionary between masses and ``scaling'' dimensions of fields and operators. We present these modifications for the general case of domain wall/QFT correspondences between supergravities on warped AdS_{d+1}xS^q geometries and super Yang-Mills theories with 16 supercharges.Comment: 7 pages, Proceedings of the RTN workshop ``The quantum structure of spacetime and the geometric nature of fundamental interactions'', Leuven, September 200

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction.

Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown. To examine this, RNU rats received intramyocardial injection of 1 × 107 NHP or human iPSC-CMs or the same number of respective fibroblasts or PBS control (n = 9-14/group) at 4 days after 60-min coronary artery occlusion-reperfusion. Cardiac function and left ventricular remodeling were similarly improved in both iPSC-CM-treated groups. To mimic the ischemic environment in the infarcted heart, both cultured NHP and human iPSC-CMs underwent 24-hr hypoxia in vitro. Both cells and media were collected, and similarities in transcriptomic as well as metabolomic profiles were noted between both groups. In conclusion, both NHP and human iPSC-CMs confer similar cardioprotection in a rodent myocardial infarction model through relatively similar mechanisms via promotion of cell survival, angiogenesis, and inhibition of hypertrophy and fibrosis

Tachyonic Inflation in a Warped String Background

We analyze observational constraints on the parameter space of tachyonic inflation with a Gaussian potential and discuss some predictions of this scenario. As was shown by Kofman and Linde, it is extremely problematic to achieve the required range of parameters in conventional string compactifications. We investigate if the situation can be improved in more general compactifications with a warped metric and varying dilaton. The simplest examples are the warped throat geometries that arise in the vicinity of of a large number of space-filling D-branes. We find that the parameter range for inflation can be accommodated in the background of D6-branes wrapping a three-cycle in type IIA. We comment on the requirements that have to be met in order to realize this scenario in an explicit string compactification.Comment: Latex, JHEP class, 20 pages, 4 figures. v2: references added, small error in section 7 corrected, published versio

A practical solution to the sign problem in a matrix model for dynamical compactification

The matrix model formulation of superstring theory offers the possibility to understand the appearance of 4d space-time from 10d as a consequence of spontaneous breaking of the SO(10) symmetry. Monte Carlo studies of this issue is technically difficult due to the so-called sign problem. We present a practical solution to this problem generalizing the factorization method proposed originally by two of the authors (K.N.A. and J.N.). Explicit Monte Carlo calculations and large-N extrapolations are performed in a simpler matrix model with similar properties, and reproduce quantitative results obtained previously by the Gaussian expansion method. Our results also confirm that the spontaneous symmetry breaking indeed occurs due to the phase of the fermion determinant, which vanishes for collapsed configurations. We clarify various generic features of this approach, which would be useful in applying it to other statistical systems with the sign problem.Comment: 44 pages, 64 figures, v2: some minor typos correcte

Canonical Quantization of Open String and Noncommutative Geometry

We perform canonical quantization of open strings in the $D$-brane background with a $B$-field. Treating the mixed boundary condition as a primary constraint, we get a set of secondary constraints. Then these constraints are shown to be equivalent to orbifold conditions to be imposed on normal string modes. These orbifold conditions are a generalization of the familiar orbifold conditions which arise when we describe open strings in terms of closed strings. Solving the constraints explicitly, we obtain a simple Hamiltonian for the open string, which reveals the nature of noncommutativity transparently.Comment: 14 pages, RevTex, added reference

SD-brane gravity fields and rolling tachyons

S(pacelike)D-branes are objects arising naturally in string theory when Dirichlet boundary conditions are imposed on the time direction. SD-brane physics is inherently time-dependent. Previous investigations of gravity fields of SD-branes have yielded undesirable naked spacelike singularities. We set up the problem of coupling the most relevant open-string tachyonic mode to massless closed-string modes in the bulk, with backreaction and Ramond-Ramond fields included. We find solutions numerically in a self-consistent approximation; our solutions are naturally asymptotically flat and time-reversal asymmetric. We find completely nonsingular evolution; in particular, the dilaton and curvature are well-behaved for all time. The essential mechanism for spacetime singularity resolution is the inclusion of full backreaction between the bulk fields and the rolling tachyon. Our analysis is not the final word on the story, because we have to make some significant approximations, most notably homogeneity of the tachyon on the unstable branes. Nonetheless, we provide significant progress in plugging a gaping hole in prior understanding of the gravity fields of SD-branes.Comment: References added. Analysis for much broader range of solutions presented. Conclusions unchanged. Time-reversal symmetric examples ruled out, new examples are provide

N=8 SCFT and M Theory on AdS_4 x RP^7

We study M theory on AdS_4 \times \RP^7 corresponding to 3 dimensional ${\cal N}=8$ superconformal field theory which is the strong coupling limit of 3 dimensional super Yang-Mills theory. For SU(N) theory, a wrapped M5 brane on \RP^5 can be interpreted as baryon vertex. For $SO(N)/Sp(2N)$ theory, by using the property of (co-)homology of \RP^7, we classify various wrapping branes and consider domain walls and the baryon vertex.Comment: 17 pages, Changed baryon like operator as M5 branes in M theory rather than D6 brane in IIA theory. To appear in Phys.Rev.

Domain-Domain Interactions Underlying Herpesvirus-Human Protein-Protein Interaction Networks

Protein-domains play an important role in mediating protein-protein interactions. Furthermore, the same domain-pairs mediate different interactions in different contexts and in various organisms, and therefore domain-pairs are considered as the building blocks of interactome networks. Here we extend these principles to the host-virus interface and find the domain-pairs that potentially mediate human-herpesvirus interactions. Notably, we find that the same domain-pairs used by other organisms for mediating their interactions underlie statistically significant fractions of human-virus protein inter-interaction networks. Our analysis shows that viral domains tend to interact with human domains that are hubs in the human domain-domain interaction network. This may enable the virus to easily interfere with a variety of mechanisms and processes involving various and different human proteins carrying the relevant hub domain. Comparative genomics analysis provides hints at a molecular mechanism by which the virus acquired some of its interacting domains from its human host