95 research outputs found
Performance of LV vacuum contactors with condensed composite multicomponent contacts
Paper presents and discusses the investigated results of LV vacuum contactors with contacts made of selected condensed composite materials under both rated and short circuit conditions of operation.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ ΡΠ° ΠΎΠ±Π³ΠΎΠ²ΠΎΡΡΡΡΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π½ΠΈΠ·ΡΠΊΠΎΠ²ΠΎΠ»ΡΡΠ½ΠΈΡ
Π²Π°ΠΊΡΡΠΌΠ½ΠΈΡ
ΠΊΠΎΠ½ΡΠ°ΠΊΡΠΎΡΡΠ² ΡΠ· ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ°ΠΌΠΈ, Π²ΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠΌΠΈ Π· Π²ΠΈΠ±ΡΠ°Π½ΠΈΡ
ΠΊΠΎΠ½Π΄Π΅Π½ΡΠΎΠ²Π°Π½ΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡΠ² Π·Π° ΡΠΌΠΎΠ² ΠΊΠΎΠΌΡΡΠ°ΡΡΠΉΠ½ΠΈΡ
Π²ΠΈΠΏΡΠΎΠ±ΡΠ²Π°Π½Ρ ΠΏΡΠΈ Π΅ΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΡΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΈΡ
ΡΠ° ΠΊΠΎΡΠΎΡΠΊΠΈΡ
Π»Π°Π½ΡΡΠ³ΡΠ².ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½ΠΈΠ·ΠΊΠΎΠ²ΠΎΠ»ΡΡΠ½ΡΡ
Π²Π°ΠΊΡΡΠΌΠ½ΡΡ
ΠΊΠΎΠ½ΡΠ°ΠΊΡΠΎΡΠΎΠ² Ρ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ°ΠΌΠΈ, ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΡΠΌΠΈ ΠΈΠ· Π²ΡΠ±ΡΠ°Π½Π½ΡΡ
ΠΊΠΎΠ½Π΄Π΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠΎΠΌΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΡΠΏΡΡΠ°Π½ΠΈΡΡ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠ°Π±ΠΎΡΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΊΠΎΡΠΎΡΠΊΠΈΡ
ΡΠ΅ΠΏΠ΅ΠΉ
Enzymatically crosslinked Tyramine-Gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction. Current strategies for the treatment of RA can reduce joint inflammation, but the treatment options still represent stability concerns since they are not sufficient and present a fast clearing. Thus, several drug delivery systems (DDS) have been advanced to tackle this limitation. Injectable gellan gum (GG) hydrogels, reduced by physical crosslinking methods, also being proposed as DDS, but this kind of crosslinking can produce hydrogels that become weaker in physiological conditions. Nevertheless, enzymatic crosslinking emerged as an alternative to increase mechanical strength, which can be adjusted by the degree of enzymatic crosslinking. In this study, tyramine-modified gellan gum (Ty-GG) hydrogels were developed via horseradish peroxidase (HRP) crosslinking; and betamethasone was encapsulated within, to increase the specificity and safety in the treatment of patients with RA. Physicochemical results showed that it was possible to modify GG with tyramine, with a degree of substitution of approximately 30%. They showed high mechanical strength and resistance, presenting a controlled betamethasone release profile over time. Ty-GG hydrogels also exhibited no cytotoxic effects and do not negatively affected the metabolic activity and proliferation of chondrogenic primary cells. Furthermore, the main goal was achieved since betamethasone-loaded Ty-GG hydrogels demonstrated to have a more effective therapeutic effect when compared with the administration of betamethasone alone. Therefore, the developed Ty-GG hydrogels represent a promising DDS and a reliable alternative to traditional treatments in patients with RANorte2020 project (βNORTE-08-5369-FSE-000044β), REMIX project (G.A. 778078 β REMIX β H2020-MSCA-RISE-2017), and Gilson Lab, Chonbuk National University, Republic of Korea. The FCT distinction attributed to J. Miguel Oliveira under the Investigator FCT program (IF/01285/2015) is also greatly acknowledged. C. GonΓ§alves also wish to acknowledge FCT for supporting her research (No. SFRH/BPD/94277/2013
Direct phloem transport and pressure concentration waves in linking shoot and rhizosphere activity.
Characterization of poly (L-co-D,L Lactic Acid) and a study of polymer-tissue interaction in subcutaneous implants in wistar rats
Studies on a primitive cerebellar cortex - II. The projection of the posterior lateral-line nerve to the lateral-line lobes of the dogfish brain
Effect of paraquat on ethylene biosynthesis by intact green Phaseolus vulgaris seedlings
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