8 research outputs found
Effect of hydraulic retention time on up-flow anaerobic stage reactor performance at constant loading in the presence of antibiotic tylosin
Full text linkPerformance of a membrane-equipped methanogenic reactor in a two-phase anaerobic digestion system
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Anaerobic digestion of a synthetic wastewater containing starch by a membrane reactor
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Immunohistochemical expression of latent membrane protein 1 (LMP1) and p53 in nasopharyngeal carcinoma: Moroccan experience
Get PDFBackground: Nasopharyngeal carcinoma (NPC) is a malignant epithelial
tumor intimately associated with Epstein-Barr virus (EBV). NPC is a
characteristic tumor displaying epidemiological, genetic and regional
distribution properties that makes it unique by its natural behavior.
Objectives: To assess the expression pattern of LMP1 and p53 proteins
in the different histological types of NPC in a sample of the Moroccan
population and to define any association between the expression of
those proteins with the sex,the age and the histological types of NPC.
Methods: Archival formalin-fixed, paraffin-embedded NPC biopsies were
evaluated in 23 Moroccan patients for the presence of LMP1 and p53
using immunohistochemistry (IHC). Results: No LMP1 expression was
observed whereas 8 of 23 cases (34. 7%) had detectable p53 protein in
the nuclei of tumor cells. After statistical analysis according to the
Fisher’s exact probability test, no significant association
between p53 expression and histological type, age and sex distributions
was demonstrated (p>0.05). Conclusion: This study confirms that p53
overexpression is present in a subset of Moroccan NPC patients. Our
results are consistent with those reported by other studies concerning
the same NPC endemic risk area and provide original data concerning
Morocco
