Region of Excessive Flux of PeV Cosmic Rays in the Direction Toward Pulsars PSR J1840+5640 and LAT PSR J1836+5925

An analysis of arrival directions of extensive air showers (EAS) registered with the EAS MSU and EAS-1000 prototype arrays has revealed a region of excessive flux of PeV cosmic rays in the direction toward pulsars PSR J1840+5640 and LAT PSR J1836+5925 at significance level up to 4.5sigma. The first of the pulsars was discovered almost 30 years ago and is a well-studied old radio pulsar located at the distance of 1.7pc from the Solar system. The second pulsar belongs to a new type of pulsars, discovered by the space gamma-ray observatory Fermi, pulsations of which are not observed in optical and radio wavelengths but only in the gamma-ray range of energies (gamma-ray-only pulsars). In our opinion, the existence of the region of excessive flux of cosmic rays registered with two different arrays provides a strong evidence that isolated pulsars can give a noticeable contribution to the flux of Galactic cosmic rays in the PeV energy range.Comment: 14 pages; v.2: a few remarks to match a version accepted for Astronomy Letters added. They can be found by redefining the \NEW command in the preamble of the LaTeX fil

Neogene calc-alkaline intrusive magmatism of post-collisional origin along the Outer Carpathians: a comparative study of the Pieniny Mountains and adjacent areas

A petrographical and geochemical analysis was carried out on intrusive rocks from the Pieniny and Moravian areas, with special attention to boron content and K-Ar radiometric ages. The intrusions form medium- to high-potassium calc-alkaline andesitic suites, which are compositionally slightly different from each other and from the other calc-alkaline sequences in the Carpathian-Pannonian Region. No significant geochemical differences were observed within the different phase intrusions in the Pieniny areas. However, there is a slight difference in major and trace element composition between the Moravian and Pieniny intrusions. The andesitic rocks in the Pieniny and Moravian area are enriched in large ion lithophile elements and light rare earth elements and depleted in high field strength elements, indicating a metasomatized mantle source of the parent magmas. The low boron concentration of the andesitic rocks in the Pieniny area is in the range measured in back-arc, intraplate basalts of the Bakony-Balaton Highland volcanic field, whereas the higher boron content of the Moravian rocks overlaps with that of the Western Carpathian andesites. This may indicates the heterogeneity of the mantle lithosphere below the areas, or indicates different magma evolution histories. On the basis of the systematic geochronological study, the intrusive rocks along the Outer Carpathians can be divided on three groups, which overlap with each other temporally. The oldest magmatism occurred from 14.8 Ma to 11.0 Ma in the Uhersky Brod area, Moravia, which was followed by the emplacement of andesitic dikes and sills in the Pieniny Mts., south Poland (13.5–10.8 Ma). In the Pieniny area, two intrusive phases were distinguished. Partly overlapping with this area, but generally younger than this magmatism, the emplacement of the youngest intrusions is referable to the Poiana Botizei-Ţibleş-Toroiaga-Rodna-Bârgâu intrusive area, Romania, where magmatic activity started at ~11.8 Ma and terminated at 8.0 Ma

Purinergic mechanisms in the control of gastrointestinal motility

For many years, ATP and adenosine have been implicated in movement regulation of the gastrointestinal tract. They act through three major receptor subtypes: adenosine or P1 receptors, P2X receptors and P2Y receptors. Each of these major receptor types can be subdivided into several different classes and is widely distributed amongst various neurons, muscle types, glia and interstitial cells that regulate intestinal functions. Several key roles for the different receptors and their endogenous ligands have been identified in physiological and pharmacological studies. For example, adenosine acting at A1 receptors appears to inhibit intestinal motility in various pathological conditions. Similarly, ATP acting at P2Y receptors is an important component of inhibitory neuromuscular transmission, acting as a cotransmitter with nitric oxide. ATP acting at P2X and P2Y1 receptors is important for synaptic transmission in simple descending excitatory and inhibitory reflex pathways. Some P2Y receptor subtypes prefer uridine nucleotides over purine nucleotides. Thus, roles for UTP and UDP as enteric transmitters in place of ATP cannot be excluded. ATP also appears to be important for sensory transduction, especially in chemosensitive pathways that initiate local inhibitory reflexes. Despite this evidence, data are lacking about the roles of either adenosine or ATP in more complex motility patterns such as segmentation or the interdigestive migrating motor complex. Clarification of roles for purinergic transmission in these common, but understudied, motility patterns will depend on the use of subtype-specific antagonists that in some cases have not yet been developed