128 research outputs found
Terahertz Room-Temperature Photonic Crystal Nanocavity Laser
We describe an efficient surface-passivated photonic crystal nanocavity
laser, demonstrating room-temperature operation with 3-ps total pulse duration
(detector response limited) and low-temperature operation with
ultra-low-threshold near 9uW.Comment: 6 pages, 3 figure
Cooperative spontaneous emission in nonuniform media
The subject of this paper is modification of cooperative spontaneous emission
by a nonuniform medium, with nonuniform distributions of electromagnetic field.
A brief analyzis is presented and it is postulated, that if spontaneous
emission from an atom is strongly suppressed, cooperative emission with another
atom may be a preferred emission channel and counteract the suppression.Comment: The final publication is available at http://www.epj.or
Visualizing dimensionality reduction of systems biology data
One of the challenges in analyzing high-dimensional expression data is the
detection of important biological signals. A common approach is to apply a
dimension reduction method, such as principal component analysis. Typically,
after application of such a method the data is projected and visualized in the
new coordinate system, using scatter plots or profile plots. These methods
provide good results if the data have certain properties which become visible
in the new coordinate system and which were hard to detect in the original
coordinate system. Often however, the application of only one method does not
suffice to capture all important signals. Therefore several methods addressing
different aspects of the data need to be applied. We have developed a framework
for linear and non-linear dimension reduction methods within our visual
analytics pipeline SpRay. This includes measures that assist the interpretation
of the factorization result. Different visualizations of these measures can be
combined with functional annotations that support the interpretation of the
results. We show an application to high-resolution time series microarray data
in the antibiotic-producing organism Streptomyces coelicolor as well as to
microarray data measuring expression of cells with normal karyotype and cells
with trisomies of human chromosomes 13 and 21
Room temperature plasmon laser by total internal reflection
Plasmon lasers create and sustain intense and coherent optical fields below
light's diffraction limit with the unique ability to drastically enhance
light-matter interactions bringing fundamentally new capabilities to
bio-sensing, data storage, photolithography and optical communications.
However, these important applications require room temperature operation, which
remains a major hurdle. Here, we report a room temperature semiconductor
plasmon laser with both strong cavity feedback and optical confinement to
1/20th of the wavelength. The strong feedback arises from total internal
reflection of surface plasmons, while the confinement enhances the spontaneous
emission rate by up to 20 times.Comment: 8 Page, 2 Figure
General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq
Background
Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to mitigate the detrimental effects of gene dose differences. However, recent genomic research on female heterogametic ZZ/ZW systems has generated surprising results. In two bird species and one lepidopteran no evidence for a global dosage compensating mechanism has been found. The recent advent of massively parallel RNA sequencing now opens up the possibility to gauge the generality of this observation with a broader phylogenetic sampling. It further allows assessing the validity of microarray-based inference on dosage compensation with a novel technology.
Results
We here expemplify this approach using massively parallel sequencing on barcoded individuals of a bird species, the European crow (Corvus corone), where previously no genetic resources were available. Testing for Z-linkage with quantitative PCR (qPCR,) we first establish that orthology with distantly related species (chicken, zebra finch) can be used as a good predictor for chromosomal affiliation of a gene. We then use a digital measure of gene expression (RNA-seq) on brain transcriptome and confirm a global lack of dosage compensation on the Z chromosome. RNA-seq estimates of male-to-female (m:f) expression difference on the Z compare well to previous microarray-based estimates in birds and lepidopterans. The data further lends support that an up-regulation of female Z-linked genes conveys partial compensation and suggest a relationship between sex-bias and absolute expression level of a gene. Correlation of sex-biased gene expression on the Z chromosome across all three bird species further suggests that the degree of compensation has been partly conserved across 100 million years of avian evolution.
Conclusions
This work demonstrates that the study of dosage compensation has become amenable to species where previously no genetic resources were available. Massively parallele transcriptome sequencing allows re-assessing the degree of dosage compensation with a novel tool in well-studies species and, in addition, gain valuable insights into the generality of mechanisms across independent taxonomic group for both the XX/XY and ZZ/ZW system
Dynamic light diffusion, Anderson localization and lasing in disordered inverted opals: 3D ab-initio Maxwell-Bloch computation
We report on 3D time-domain parallel simulations of Anderson localization of
light in inverted disordered opals displaying a complete photonic band-gap. We
investigate dynamic diffusion processes induced by femtosecond laser
excitations, calculate the diffusion constant and the decay-time distribution
versus the strength of the disorder. We report evidence of the transition from
delocalized Bloch oscillations to strongly localized resonances in
self-starting laser processes.Comment: 4 pages, 5 figure
The Impact of Profit Taxation on Capitalized Investment with Options to Delay and Divest
Eine Bilanzierung der Verschiebungen der Lebensverlauf-Beschäftigungsprofile von verheirateten Frauen der Jahrgänge zwischen 1940 und 1960
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