Delivering and participating in a psycho- educational intervention for family caregivers during palliative home care: a qualitative study from the perspectives of health professionals and family caregivers

Abstract Background: Family caregivers in palliative care have a need for knowledge and support from health professionals, resulting in the need for educational and supportive interventions. However, research has mainly focused on the experiences of family caregivers taking part in interventions. To gain an increased understanding of complex interventions, it is necessary to integrate the perspectives of health professionals and family caregivers. Hence, the aim of this study is to explore the perspectives of health professionals and family caregivers of delivering and participating in a psycho-educational intervention in palliative home care. Methods: A psycho-educational intervention was designed for family caregivers based on a theoretical framework describing family caregiver's need for knowing, being and doing. The intervention was delivered over three sessions, each of which included a presentation by healthcare professionals from an intervention manual. An interpretive descriptive design was chosen and data were collected through focus group discussions with health professionals and individual interviews with family caregivers. Data were analysed using framework analysis

Doxorubicin-induced skeletal muscle atrophy:Elucidating the underlying molecular pathways

AIM: Loss of skeletal muscle mass is a common clinical finding in cancer patients. The purpose of this meta-analysis and systematic review was to quantify the effect of doxorubicin on skeletal muscle and report on the proposed molecular pathways possibly leading to doxorubicin-induced muscle atrophy in both human and animal models. METHODS: A systematic search of the literature was conducted in PubMed, EMBASE, Web of Science and CENTRAL databases. The internal validity of included studies was assessed using SYRCLE's risk of bias tool. RESULTS: Twenty eligible articles were identified. No human studies were identified as being eligible for inclusion. Doxorubicin significantly reduced skeletal muscle weight (ie EDL, TA, gastrocnemius and soleus) by 14% (95% CI: 9.9; 19.3) and muscle fibre cross-sectional area by 17% (95% CI: 9.0; 26.0) when compared to vehicle controls. Parallel to negative changes in muscle mass, muscle strength was even more decreased in response to doxorubicin administration. This review suggests that mitochondrial dysfunction plays a central role in doxorubicin-induced skeletal muscle atrophy. The increased production of ROS plays a key role within this process. Furthermore, doxorubicin activated all major proteolytic systems (ie calpains, the ubiquitin-proteasome pathway and autophagy) in the skeletal muscle. Although each of these proteolytic pathways contributes to doxorubicin-induced muscle atrophy, the activation of the ubiquitin-proteasome pathway is hypothesized to play a key role. Finally, a limited number of studies found that doxorubicin decreases protein synthesis by a disruption in the insulin signalling pathway. CONCLUSION: The results of the meta-analysis show that doxorubicin induces skeletal muscle atrophy in preclinical models. This effect may be explained by various interacting molecular pathways. Results from preclinical studies provide a robust setting to investigate a possible dose-response, separate the effects of doxorubicin from tumour-induced atrophy and to examine underlying molecular pathways. More research is needed to confirm the proposed signalling pathways in humans, paving the way for potential therapeutic approaches

Patients need to know

Dr Yvonne Wengstrom (Karolinska Institutet, Stockholm, Sweden) is President of the European Oncology Nursing Society (EONS). She coordinates Care Science Research at the Karolinska Institutet and mentors undergraduate and postgraduate research students in oncology nursing. She is a member of the GAEA (Gathering Information on Adjuvant Endocrine Therapy) Initiative steering committee and recently led a survey which asked more than 500 women in 9 European countries about their experience of receiving adjuvant endocrine therapy for recently diagnosed breast cancer

Symptom experiences during chemotherapy treatment—With focus on nausea and vomiting

Nausea and vomiting are common and well-studied symptoms in cancer care. Most previous studies have focused on the frequency and management of these symptoms. The aim of the study was to acquire a deeper understanding of cancer patients’ symptom experiences with a focus on nausea and vomiting during chemotherapy treatment, and the consequences these have on their daily lives. Nine women with different types of cancer and chemotherapy treatments were admitted for chemotherapy treatment and participated in the study. Semistructured interviews were conducted and analysed using content analysis inspired by Kvale’s methods of clarifying and developing new meaning. Five main categories were identified as ’’before cancer diagnosis’’, ’’being ill—consequences on daily life’’, ’’ going through chemotherapy treatment’’, ’’coping with treatment’’ and ’’after treatment—looking forward to a normal life’’. The present findings suggest that the individual experiences of nausea and vomiting during chemotherapy treatment may have a profound effect on how treatment is perceived and may influence future decisions concerning further treatment

European Oncology Nursing Society extravasation guidelines

An infrequent, but potential complication of chemotherapy is vesicant chemotherapy extravasation. Vesicants have the potential to cause blistering and ulceration when they extravasate from the vein or are inadvertently administered into the tissue. In 2007, the European Oncology Nursing Society published guidelines for extravasation prevention, detection, and management. Recommended management includes topical heating for plant alkaloid extravasations and topical cooling for anthracycline and other antitumor antibiotic vesicants. For treatment of antracycline extravasations topical dimethylsulfoxide (DMSO), sodium thiosulfate, and hyaluronidase have been described in the literature but due to lack of evidence to support their use as vesicant extravasation antidotes, it is recommended that these agents are studied further. Furthermore, Savenes (dexrazoxane) is the only registered drug for the treatment of antracycline extravasation. Nurses need to be aware of current evidence-based guidelines for detecting and managing vesicant extravasations and need to be prepared to administer evidence-based treatment

Nurses in cancer care—Stress when encountering existential issues

Previous research related to stress among health care staff has highlighted several complex issues; however, a deeper analysis of the existential components has been lacking. The purpose of this paper is to study the stress of registered nurses who work with terminally ill and dying cancer patients, according to an earlier model developed by Ekedahl [2001. How can you bear the Challenge of Working at the Edges of Life and Death? Coping Processes with Hospital Chaplains Encountering Existential Confrontation: a Study in Psychology of Religion., Uppsala University, Thesis Uppsala]. The present study is qualitative and hypothesis-generating. The material analyzed are based on a life story approach and interviews carried out with 15 Swedish nurses working in hospices, oncology wards, and outpatient services for patients with advanced cancer. The nurses’ stress levels ranged from low to severe, including multifaceted stress with existential dimensions. Different types of stress appear to be related with the individual, group, institutional, and cultural level

Nurses in cancer care—coping strategies when encountering existential issues

Summary This paper is a presentation of general/secular coping strategies and strategies related to the caritas orientation that nurses in cancer care use when encountering stress. As a concept, caritas indicates the will to do good. The paper tries to provide an answer to the question of which functional and dysfunctional coping strategies nurses use when coping with work-related stress. The study is qualitative and hypothesis-generating. The material analysed consists of 15 interviews with Swedish registered nurses and is based on a life-story approach. Pargament’s coping theory related to the psychology of religion has been applied for interpretation purposes. The nurses use several coping strategies with the dominant strategy being a general boundary demarcation. Other strategies that were used for coping included emotional outlets, caritas—oblivion and periodically changing activity. The strategies can be used in a functional or dysfunctional way; e.g. dysfunctional coping was present when there was a lack of human support and boundary demarcation

Supportive care for patients with oesophageal and other upper gastrointestinal cancers: The role of a specialist nurse in the team

Summary The care pathway of patients with upper gastrointestinal cancers is complex. We retrospectively evaluated the patients’ opinions of support and supportive care given by a specialist nurse who led the care of such patients. A study-specific questionnaire addressed the support given by the specialist nurse and other professionals in the team before, during and after treatment. Virtually all 73 responders considered the support of the specialist nurse important (87–94%). This support seemed more appreciated than that of outpatient clinic (P ¼ 0:00) and surgical ward staff (P ¼ 0:01) during the diagnostic phase, and during the follow-up it became more important than that of all other team professionals. A second studyspecific questionnaire assessed the supportive care. Of 49 patients, 71–94% completely agreed that the supportive care given by the specialist nurse was satisfactory, and 90–100% considered it important. Whereas 10% had difficulty in understanding physicians’ information, none had such problems regarding information given by the nurse (P ¼ 0:09). Review of documented contacts between the specialist nurse and 75 patients with oesophago-gastric cancer revealed that contacts were frequent during follow-up, and nutritional problems predominated. Thus, specialist nurses can be recommended as leaders of the care pathway of patients with upper gastrointestinal cancers

European Oncology Nursing Society breakthrough cancer pain guidelines

Purpose: The overall aim of the project was to update and inform nurses of current best practice based on previously published literature to enable nurses to assess and manage breakthrough cancer pain (BTCP) and thereby to provide optimal management of BTCP. Methods: The EONS started a project in 2010 by recruiting a working group and a multidisciplinary advisory board to develop guidelines with the purpose of helping oncology nurses understand and recognise BTCP. Results: This paper presents and overview of the guideline. Key recommendations include; using an algorithm for assessment of BTCP, individualise treatment interventions, optimization of analgesia and reassessment of outcomes of interventions. Conclusions: By implementing the EONS guidelines nurses will utilise the latest available knowledge in clinical practice and the understanding and management of BTCP will improve assessment and overall management of breakthrough pain in cancer patients. (C) 2013 Elsevier Ltd. All rights reserved