Approche du patrimoine hospitalier en Bourgogne à travers une tradition charitable du XIII e siècle

Hospital heritage in Burgundy through the specific case study of Hôtel-Dieu de Tonnerre – The authors’ attention has been caught by an interesting 2011 publication “Patrimoine hospitalier en Bourgogne” which highlights the strong tradition for hospital and charity foundations in Burgundy. This also demonstrates the great European Instances interest in “the present and future of European hospital heritage”. The authors show how some of the modern health concerns were already present in Burgundy from XIII century especially with “ N. D. des Fontenilles” the outstanding Hôtel-Dieu in Tonnerre.Approche du patrimoine hospitalier en Bourgogne à travers une tradition charitable du XIIIe siècle – Les auteurs signalent la parution en 2011 du document Patrimoine hospitalier en Bourgogne (Somogy Éditions d’art) qui relève tout à la fois la richesse et l’ancienneté des fondations hospitalières et charitables dans cette région. La publication témoigne en outre de l’intérêt porté par les Institutions européennes quant «au présent et à l’avenir du patrimoine hospitalier». En mentionnant l’Hôtel-Dieu N.-D. des Fontenilles à Tonnerre, fondé en 1292 par Marguerite de Bourgogne, les auteurs montrent combien certaines préoccupations «modernes » d’ordre sanitaire étaient présentes en Bourgogne dès le XIIIe siècle.Pourcelot-Roubeau Yvette, Pourcelot Alain. Approche du patrimoine hospitalier en Bourgogne à travers une tradition charitable du XIII e siècle. In: Revue d'histoire de la pharmacie, 100e année, N. 377, 2013. pp. 101-108

Prise en charge à l'officine du psoriasis

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

Valorisation de la fonctionnalité des poudres microenrobées par des lipides

DIJON-BU Médecine Pharmacie (212312103) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

The spray drying of acetazolamide as a method to modify crystal properties and to improve compression behaviour

Acetazolamide shows a very poor compression ability and tablets must usually be produced through a wet granulation process. However, the possibility to obtain pure acetazolamide for direct compression could be interesting for industrial application. With the scope to obtain a material for direct compression, three different crystallisation methods were chosen, with respect to acetazolamide solvent solubility. (a) Acetazolamide was dissolved in an ammonia solution and then spray dried. It was possible to characterise the spherical particles as a mixture of two polymorphic forms, I and II by Powder X-ray diffraction study. (b) Pure form I was obtained by slowly cooling to room temperature a boiling water solution. (c) Pure form II, the marketed form, was obtained by neutralisation of an ammonia solution. Their compression behaviour was investigated firstly by a rotary press. Whilst pure polymorphic forms I and II could not be compressed, the spray dried particles showed very good compression properties. In fact, tablets were obtained only by spray dried particles, which show very good properties under compression and the absence of capping tendency. On the other hand, it was impossible to obtain tablets from polymorphic forms I and II, whatever compression pressures were used. In order to explain their densification mechanism, a single-punch tablet machine, equipped for the measurement of the upper punch displacement in the die, was used. From calculated Heckel’s parameters, it was demonstrated that the spray dried material shows a greater particle rearrangement in the initial stage of compression due to its spherical habit and minor wrinkledness of particle surface. The crystalline structure due to the presence of polymorphic forms I and II concur to lowering the intrinsic elasticity of the material. This fact avoids the risk of the rupturing the interpaticulate bonds, which are formed during the compression, concurring to the consolidation of the tablet