109 research outputs found

    Le personnage de Grisildis dans The Clerk's Tale de Chaucer : un discours sur l’effacement ?

    Get PDF
    Dès le prologue du Conte de l’Universitaire d’Oxford, l’Hôtelier impose les formes du conte qu’il attend de l’Universitaire, un « beau récit d’aventures ». Le thème de l’obéissance structure l’ensemble du conte. S’agit-il d’un plaidoyer en faveur de la soumission des femmes que la patience transformerait en saintes, en héroïnes dignes de figurer dans les récits hagiographiques ? Que signifie l’effacement de Grisildis ? Le narrateur cherche-t-il à peindre une Grisildis effacée ou plutôt à effacer ce type de femme admirable, certes, mais peu authentique ? Le conte ne suggère-t-il pas au contraire l’envers de ce décor, teinté de légendaire, ainsi que les coulisses d’un monde réel reflétant les mutations économiques et sociales de l’Angleterre du xive siècle.The prologue of The Clerk’s Tale broaches the problem of obedience both explicitly and ambiguously since obedience has several meanings. The Host imposes the form, structure and contents of the tale which must be som murie thyng of aventures. This article is a reflection on obedience and on the obvious or hidden intentions of the tale: should it be read as a plea vindicating obedience and patience granting women and wives a holy or heroic status? Does the narrator aim at emphasizing the virtues of a self-effacing wife or rather to efface this type of admirable but unauthentic women? The tale may seek to contrast this portrayal with references to more legendary figures ambiguously set against the realistic backdrop of the social economic changes of xivth century England

    Marie-Pascale Halary, La Question de la beauté et le discours romanesque au début du xiiie siècle

    Get PDF
    Dans le sillage de sa thèse intitulée Beauté et littérature au tournant des xiie et xiiie siècles, Marie-Pascale Halary revient sur une problématique dont l’approche est propre au Moyen Âge : la beauté. Problématique évidente si l’on pense, par ex., à la culture matérielle et aux productions artistiques, qui puisent abondamment leur inspiration dans les sujets littéraires, la beauté comporte cependant une dimension théologique spécifique à l’époque et à la perception de l’image ainsi que les ..

    The Cellular Prion Protein PrPc Is Involved in the Proliferation of Epithelial Cells and in the Distribution of Junction-Associated Proteins

    Get PDF
    BACKGROUND: The physiological function of the ubiquitous cellular prion protein, PrP(c), is still under debate. It was essentially studied in nervous system, but poorly investigated in epithelial cells. We previously reported that PrP(c) is targeted to cell-cell junctions of polarized epithelial cells, where it interacts with c-Src. METHODOLOGY/FINDINGS: We show here that, in cultured human enterocytes and in intestine in vivo, the mature PrP(c) is differentially targeted either to the nucleus in dividing cells or to cell-cell contacts in polarized/differentiated cells. By proteomic analysis, we demonstrate that the junctional PrP(c) interacts with cytoskeleton-associated proteins, such as gamma- and beta-actin, alpha-spectrin, annexin A2, and with the desmosome-associated proteins desmoglein, plakoglobin and desmoplakin. In addition, co-immunoprecipitation experiments revealed complexes associating PrP(c), desmoglein and c-Src in raft domains. Through siRNA strategy, we show that PrP(c) is necessary to complete the process of epithelial cell proliferation and for the sub-cellular distribution of proteins involved in cell architecture and junctions. Moreover, analysis of the architecture of the intestinal epithelium of PrP(c) knock-out mice revealed a net decrease in the size of desmosomal junctions and, without change in the amount of BrdU incorporation, a shortening of the length of intestinal villi. CONCLUSIONS/SIGNIFICANCE: From these results, PrP(c) could be considered as a new partner involved in the balance between proliferation and polarization/differentiation in epithelial cells
    • …
    corecore