1 research outputs found
Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8
Baicalein,
a flavonoid derived from the roots of <i>Scutellariae
baicalensis</i> Georgi, has shown health benefits for an array
of human diseases including dementia. The senescence-accelerated mouse
prone 8 (SAMP8) strain is extensively used as a senile dementia model.
To further investigate the effects of baicalein in SAMP8 mice, behavioral
testing, biochemical detection, and gut microbiota analysis were performed.
The results demonstrated that treatment with baicalein ameliorated
the senescence status of the SAMP8 mice, as manifested by reducing
the grading score of senescence. Additionally, baicalein improved
the cognitive functions of the SAMP8 mice, including spatial learning
and memory abilities, object recognition memory, and olfactory memory.
Furthermore, baicalein significantly inhibited the release of proinflammatory
cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1β),
and tumor necrosis factor-α (TNF-α) in the brain cortex
of SAMP8 mice. Gut microbiota analysis revealed that treatment with
baicalein markedly altered the abundance of six genera in SAMP8 mice.
Correlation analysis indicated that the abundances of <i>Mucispirillum</i>, <i>Bacteroides</i>, and <i>Sutterella</i> were
negatively correlated with cognitive abilities and that <i>Christensenellaceae</i> was positively correlated with cognition. Furthermore, the abundance
of <i>Christensenellaceae</i> was negatively correlated
with the levels of IL-6 and TNF-α, while [<i>Prevotella</i>] was positively correlated with the levels of IL-1β and IL-6.
In addition, <i>Mucispirillum</i> and <i>Bacteroides</i> were positively correlated with the level of IL-6 in the brain
cortex. These data indicated that baicalein ameliorates senescence
status and improves cognitive function in SAMP8 mice and that this
effect might be attributable to suppression of cortical proinflammatory
cytokines and modulation of the intestinal microbiome