2 research outputs found
Table1_Strategies for Improving Postpartum Contraception Compared With Routine Maternal Care: A Systematic Review and Meta-Analysis.PDF
Objectives: This study aimed to systematically review the effectiveness of service interventions for improving postpartum contraception, including contraceptive use, prevention of repeat pregnancies and induced abortions.Methods: A systematic literature search was conducted in three databases until June 2022 (PROSPERO registration CRD42022328349). Estimates of intervention effects from meta-analyses were represented as odds ratios (OR) with 95% confidence intervals (CI).Results: 16 studies with 14,289 participants were included, with four kinds of interventions recognized. Interventions effect in increasing use of contraceptives and decreasing rates of repeated pregnancy for up to 6 months postpartum (OR = 2.24, 0.06, 95% CI = 1.46–3.44, 0.02–0.22, respectively), with no significant associations with contraceptive use at 12 months postpartum, prevention of postpartum repeat pregnancies and induced abortions during 1 year after childbirth.Conclusion: We concluded that interventions impact the initiation of postpartum contraceptive use and prevention of repeat pregnancy with an overall certainty from low to moderate. These findings highlight the need for additional studies to integrate the beneficial effect of several interventions and then design more feasible strategies, which is important for the maternal and child healthcare systems.</p
Nanocolloidosomes with Selective Drug Release for Active Tumor-Targeted Imaging-Guided Photothermal/Chemo Combination Therapy
Selective drug release
is highly desirable for photothermal/chemo combination therapy when
two or even more theranostic agents are encapsulated together within
the same nanocarrier. A conventional nanocarrier can hardly achieve
this goal. Herein, doxorubicin and indocyanine green (DOX/ICG)-loaded
nanocolloidosomes (NCs), with selective drug release, were fabricated
as a novel multifunctional theranostic nanoplatform for photothermal/chemo
combination therapy. Templating from galactose-functionalized hydroxyethyl
starch-polycaprolactone (Gal-HES-PCL) nanoparticles-stabilized Pickering
emulsions, the resultant DOX/ICG@Gal-HES-PCL NCs had a diameter of
around 140 nm and showed an outstanding tumor-targeting ability, preferable
tumor penetration capability, and promotion of photothermal effect.
Moreover, these NCs can be used for NIR fluorescence imaging and thus
render real-time imaging of solid tumors with high contrast. Collectively,
such NCs achieved the best in vivo antitumor efficacy combined with
laser irradiation compared with DOX/ICG@HES-PCL NCs and DOX/ICG mixture.
These NCs are valuable for active tumor-targeted imaging-guided combination
therapy against liver cancer and potentially other diseases