Image_2_Global trends and hotspots in research on osteoporosis rehabilitation: A bibliometric study and visualization analysis.PNG

BackgroundThe field of rehabilitation medicine plays an essential role in the comprehensive management of osteoporosis and its consequences. The benefits of therapeutic exercise are increasingly being recognized in this area, which receives an increasing number of publications. this study was designed to comprehensively identify collaborative networks, parse and track research trends, spotlight present hotspots, and accurately predict frontiers and focus on the health topics related to osteoporosis rehabilitation.MethodsThis research adopted computer retrieval of osteoporosis rehabilitation-related research published in the Web of Science Core Collection (WoSCC) from inception to June 14, 2022. The bibliometric visualization and comparative analysis involving countries, institutions, journals, authors, references, and keywords were performed using the CiteSpace and VOSviewer software.ResultsA total of 3,268 articles were included, and the number of articles published each year has demonstrated a steady increase. The United States and the University of Melbourne were the highest productive country and institution, with 1,325 and 87 articles, respectively. The journal of osteoporosis international has published the greatest number of articles, with 221 publications, and the journal of bone and mineral research ranked first in the co-citation counts (cited by 11,792 times). The most productive and highly-cited authors were Heinonen A and Cummings S, with 35 publications and 680 citations.ConclusionsAt present, “physical activity,” “weight bearing exercise,” “muscle strength,” “whole body vibration,” “postmenopausal women,” “older women,” children, men are the noteworthy research hot topics. Future research that focus on the major modes and parameters of physical activity/exercise for osteoporosis (including whole body vibration, weight bearing exercises, resistance training), targeted multicomponent training regimens, rehabilitation therapy for postmenopausal women, older women, children and men, osteoporosis related-sarcopenia and fractures, and mesenchymal stem cells are becoming frontiers and focus on the health topics related to osteoporosis rehabilitation in the upcoming years, which are worthy of further exploration.</p

Image_1_Global trends and hotspots in research on osteoporosis rehabilitation: A bibliometric study and visualization analysis.JPEG

BackgroundThe field of rehabilitation medicine plays an essential role in the comprehensive management of osteoporosis and its consequences. The benefits of therapeutic exercise are increasingly being recognized in this area, which receives an increasing number of publications. this study was designed to comprehensively identify collaborative networks, parse and track research trends, spotlight present hotspots, and accurately predict frontiers and focus on the health topics related to osteoporosis rehabilitation.MethodsThis research adopted computer retrieval of osteoporosis rehabilitation-related research published in the Web of Science Core Collection (WoSCC) from inception to June 14, 2022. The bibliometric visualization and comparative analysis involving countries, institutions, journals, authors, references, and keywords were performed using the CiteSpace and VOSviewer software.ResultsA total of 3,268 articles were included, and the number of articles published each year has demonstrated a steady increase. The United States and the University of Melbourne were the highest productive country and institution, with 1,325 and 87 articles, respectively. The journal of osteoporosis international has published the greatest number of articles, with 221 publications, and the journal of bone and mineral research ranked first in the co-citation counts (cited by 11,792 times). The most productive and highly-cited authors were Heinonen A and Cummings S, with 35 publications and 680 citations.ConclusionsAt present, “physical activity,” “weight bearing exercise,” “muscle strength,” “whole body vibration,” “postmenopausal women,” “older women,” children, men are the noteworthy research hot topics. Future research that focus on the major modes and parameters of physical activity/exercise for osteoporosis (including whole body vibration, weight bearing exercises, resistance training), targeted multicomponent training regimens, rehabilitation therapy for postmenopausal women, older women, children and men, osteoporosis related-sarcopenia and fractures, and mesenchymal stem cells are becoming frontiers and focus on the health topics related to osteoporosis rehabilitation in the upcoming years, which are worthy of further exploration.</p

Table_2_Global trends and hotspots in research on osteoporosis rehabilitation: A bibliometric study and visualization analysis.DOC

BackgroundThe field of rehabilitation medicine plays an essential role in the comprehensive management of osteoporosis and its consequences. The benefits of therapeutic exercise are increasingly being recognized in this area, which receives an increasing number of publications. this study was designed to comprehensively identify collaborative networks, parse and track research trends, spotlight present hotspots, and accurately predict frontiers and focus on the health topics related to osteoporosis rehabilitation.MethodsThis research adopted computer retrieval of osteoporosis rehabilitation-related research published in the Web of Science Core Collection (WoSCC) from inception to June 14, 2022. The bibliometric visualization and comparative analysis involving countries, institutions, journals, authors, references, and keywords were performed using the CiteSpace and VOSviewer software.ResultsA total of 3,268 articles were included, and the number of articles published each year has demonstrated a steady increase. The United States and the University of Melbourne were the highest productive country and institution, with 1,325 and 87 articles, respectively. The journal of osteoporosis international has published the greatest number of articles, with 221 publications, and the journal of bone and mineral research ranked first in the co-citation counts (cited by 11,792 times). The most productive and highly-cited authors were Heinonen A and Cummings S, with 35 publications and 680 citations.ConclusionsAt present, “physical activity,” “weight bearing exercise,” “muscle strength,” “whole body vibration,” “postmenopausal women,” “older women,” children, men are the noteworthy research hot topics. Future research that focus on the major modes and parameters of physical activity/exercise for osteoporosis (including whole body vibration, weight bearing exercises, resistance training), targeted multicomponent training regimens, rehabilitation therapy for postmenopausal women, older women, children and men, osteoporosis related-sarcopenia and fractures, and mesenchymal stem cells are becoming frontiers and focus on the health topics related to osteoporosis rehabilitation in the upcoming years, which are worthy of further exploration.</p

Table_1_Global trends and hotspots in research on osteoporosis rehabilitation: A bibliometric study and visualization analysis.DOC

BackgroundThe field of rehabilitation medicine plays an essential role in the comprehensive management of osteoporosis and its consequences. The benefits of therapeutic exercise are increasingly being recognized in this area, which receives an increasing number of publications. this study was designed to comprehensively identify collaborative networks, parse and track research trends, spotlight present hotspots, and accurately predict frontiers and focus on the health topics related to osteoporosis rehabilitation.MethodsThis research adopted computer retrieval of osteoporosis rehabilitation-related research published in the Web of Science Core Collection (WoSCC) from inception to June 14, 2022. The bibliometric visualization and comparative analysis involving countries, institutions, journals, authors, references, and keywords were performed using the CiteSpace and VOSviewer software.ResultsA total of 3,268 articles were included, and the number of articles published each year has demonstrated a steady increase. The United States and the University of Melbourne were the highest productive country and institution, with 1,325 and 87 articles, respectively. The journal of osteoporosis international has published the greatest number of articles, with 221 publications, and the journal of bone and mineral research ranked first in the co-citation counts (cited by 11,792 times). The most productive and highly-cited authors were Heinonen A and Cummings S, with 35 publications and 680 citations.ConclusionsAt present, “physical activity,” “weight bearing exercise,” “muscle strength,” “whole body vibration,” “postmenopausal women,” “older women,” children, men are the noteworthy research hot topics. Future research that focus on the major modes and parameters of physical activity/exercise for osteoporosis (including whole body vibration, weight bearing exercises, resistance training), targeted multicomponent training regimens, rehabilitation therapy for postmenopausal women, older women, children and men, osteoporosis related-sarcopenia and fractures, and mesenchymal stem cells are becoming frontiers and focus on the health topics related to osteoporosis rehabilitation in the upcoming years, which are worthy of further exploration.</p

TUNEL staining in the inferior retinas after PONT.

<p>(A) The number of positive-staining cells increased significantly in the inferior retinas 1 week after PONT, compared with the normal retinas (P<0.01). There were no significant differences between normal and any other group. (B) The positive cells in the GCL of the inferior retina 1 week after PONT (red). The positive staining was located in the nuclei (C, D), which is shown with DAPI (blue). (n = 4, 3, 3, 5 and 4 in normal, 12 h, 1d, 4d and 1w groups respectively.).</p

Western-blot analysis of the inferior retinas after PONT.

<p>Each band from one animal. (A) The expression levels of TNF-α in the inferior retinas did not change after PONT at different time-points (P>0.05). (B) MnSOD level increased significantly 1 day after PONT and had returned to normal 4 days after PONT (*P<0.05) (C) P-JNK1 level did not change after PONT (P>0.05). P-JNK2/3 levels increased significantly from 1 day until 1 week after PONT (*P<0.05). (D) The levels of p-c-jun increased from 1 day until 1 week after PONT (*P<0.05). (n = 3 in each group.).</p

Western-blot analysis of the inferior retinas after treatment with PBS or LBP.

<p>Each band is from one animal. (A) The expression of MnSOD 1 day after PONT both in PBS and LBP groups. (B, C, D, E) The expressions of p-JNK2/3, p-c-jun, BDNF, IGF-1 both 1 day and 1 week after PONT both in PBS and LBP groups. (n = 3, 3, 5 and 4 in PBS 1 day, LBP 1 day, PBS 1 week and LBP 1 week groups respectively.).</p

Schematic diagrams showing the procedures for the estimation of RGC survival.

<p>Rats were fed with PBS or LBP 1 week before CONT or PONT until sacrifice. (A) In CONT experiments, CONT was performed and then a piece of gelatin soaked with FG was placed close to the ON stump to label RGCs on day 0. Rats were sacrificed 1 week or 2 weeks after surgery. (B) In PONT experiments, SC labeling was performed 1 week before PONT and rats were sacrificed 1 week or 4 weeks after surgery.</p

Effects of LBP on survival of RGCs 1 week and 2 weeks after CONT.

<p>RGCs were labeled by FG. The arrows indicate microglia which were easily distinguished from RGCs and not counted. The blue arrowheads indicate RGCs. (A, C, D) Orally feeding of 0.1 mg/kg, 1 mg/kg and 10 mg/kg LBP showed no significant effects on the survival of RGCs 1 week after CONT (compared with PBS group) and no significant difference among the three different dosages of LBP groups was detected. (A, E, F) 1 mg/kg LBP showed no significant effects on the survival of RGCs 2 weeks after CONT (compared with PBS group). (n = 10, 8, 16, 12 in PBS, 0.1 mg/kg LBP, 1 mg/kg LBP, 10 mg/kg LBP groups sacrificed 1 week after CONT and n = 7 and 6 in PBS and 1 mg/kg LBP groups sacrificed 2 weeks after CONT.).</p

Western-blot analysis of the inferior retinas after treatment with PBS or LBP.

<p>(A) LBP increased the expression of MnSOD 1 day after PONT (*P<0.05). (B, C) LBP decreased the expression of p-JNK2/3 and p-c-jun (*P<0.05). (D) LBP did not change the expression of BDNF either 1 day or 1 week after PONT (P>0.05). (E) LBP increased the expression of IGF-1 1 day after PONT (*P<0.05), but did not change the expression of IGF-1 1 week after PONT (P>0.05). (n = 3, 3, 5 and 4 in PBS 1 day, LBP 1 day, PBS 1 week and LBP 1 week groups respectively.).</p