Additional file 6 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 6: Table S8. Single-cell differentially expressed mRNA in overall cells between COPD patient and healthy control. Table S9. Gene list for construction of protein–protein interaction networ

Additional file 7 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 7: Fig. S3. Functional analysis of DEGs in other clusters between patients with COPD and healthy controls. Bubble plot of KEGG showing the biological function of DEGs in (A) cluster 0, (B) cluster 3, (C) cluster 5, (D) cluster 7, (E) cluster 8, (F) cluster 11, (G) cluster 13, (H) cluster 16. The dot sizes represent enrichment abundance while the colours represent the Q values (blue to red). DEGs: Differentially expressed genes, KEGG: Kyoto Encyclopedia of Genes and Genomes

Additional file 5 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 5: Fig. S2. Functional analysis of marker genes in other clusters. Bubble plot of KEGG showing the biological function of (A) cluster 3, (B) cluster 4, (C) cluster 6, (D) cluster 9, (E) cluster 10, (F) cluster 11, (G) cluster 12, (H) cluster 13, (I) cluster 14, (J) cluster 15, (K) cluster 16, and (L) cluster 17. The dot sizes represent enrichment abundance while the colours represent the Q values (blue to red). KEGG: Kyoto Encyclopedia of Genes and Genomes

Additional file 1 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 1: Table S1. The expression matrix of exosomal RNA sequencing

Additional file 3 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 3: Fig. S1. Correlation between expression level of differentially expressed mRNA and clinical variables. The significant correlations between differentially expressed mRNA and clinical variables were plotted. CAT: COPD assessment test, sneu: sputum neutrophil, slym: sputum lymphocyte, smac: sputum macrophage, seos: sputum eosinophil

Additional file 2 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 2: Table S2. Exosomal differentially expressed mRNA between COPD patient and healthy control. Table S3. Exosomal differentially expressed lncRNA between COPD patient and healthy control. Table S4. Exosomal differentially expressed circRNA between COPD patient and healthy control

Additional file 4 of Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Additional file 4: Table S5. Pairs of mRNA-miRNA predicted by TargetScan. Table S6. Pairs of lncRNA-miRNA predicted by miRcode. Table S7. Pairs of circRNA-miRNA predicted by starBase