3 research outputs found
Porous Zirconium Metal–Organic Framework Constructed from 2D → 3D Interpenetration Based on a 3,6-Connected kgd Net
A new
porous zirconium metal–organic framework (Zr MOF), Zr<sub>6</sub>(μ<sub>3</sub>-O)<sub>4</sub>(μ<sub>3</sub>-OH)<sub>4</sub>(OH)<sub>6</sub>(H<sub>2</sub>O)<sub>6</sub>(BTB)<sub>2</sub>·6DMF·H<sub>2</sub>O (<b>1</b>; H<sub>3</sub>BTB = 5′-(4-carboxyphenyl)Â[1,1′:3′,1″-terphenyl]-4,4″-dicarboxylic
acid), based on Zr<sub>6</sub> clusters and tricarboxylate ligands
has been constructed and characterized. The Zr<sub>6</sub> clusters
were linked by BTB ligands to generate a 2D network of kgd topology.
The interpenetrations among the 2D networks gave rise to a 3D porous
framework, which represents the first Zr MOF constructed from 2D →
3D interpenetration. The gas uptake and catalytic properties for <b>1</b> have also been studied
Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy
Currently, no effective
and safe medicines are available to treat
diabetic nephropathy (DN). Bardoxolone methyl (CDDO-Me) has displayed
promising anti-DN activity as well as serious side effects in clinical
trials, probably because the highly reactive α-cyano-α,β-unsaturated
ketone (CUK) in ring A of CDDO-Me can covalently bind to thiol functionalities
in many biomacromolecules. In this study, we designed and synthesized
a γ-glutamyl transpeptidase (GGT)-based and CUK-modified derivative
of CDDO-Me (<b>2</b>) to address this issue. <b>2</b> can
be specifically cleaved by GGT, which is highly expressed in the kidney,
to liberate CDDO-Me in situ. It should be noted that <b>2</b> exhibited anti-DN efficacy comparable to that of CDDO-Me with much
less toxicity in cells and <i>db</i>/<i>db</i> mice, suggesting that its safety is better than CDDO-Me. Our findings
not only reveal the therapeutic potential of <b>2</b> but also
provide a strategy to optimize other synthetic molecules or natural
products bearing a pharmacophore like CUK to achieve safer pharmaceutical
drugs
A Zn Metal–Organic Framework with High Stability and Sorption Selectivity for CO<sub>2</sub>
A three-dimensional porous Zn metal–organic
framework (<b>UPC-12</b>) with high thermal and chemical stability
was isolated in high yield and purity from a hydrothermal reaction. <b>UPC-12</b> exhibits high selectivity for CO<sub>2</sub> due to
the formation of hydrogen bonds between CO<sub>2</sub> molecules and
the −COOH groups exposed inside the channels and the effective
π–π interactions between CO<sub>2</sub> molecules
and the pillared bipyridine moieties of the MOF. The adsorption–desorption
process was studied, for the first time, by both <sup>13</sup>C CP-TOSS
NMR spectroscopy and in situ DRIFTS