A Study on Raththa Moolam

Since the most common disease in the modern society is Raththa Moolam, number of sufferers may be increasing day by day. So the author had selected this disease for this dissertation work. 20 patients of either sex were selected as both In-patients and out-patients and they were administered with the trial drug Raththa Moola Nei– 4gm twice daily during the whole study period. The trial drugs were subjected to biochemical and pharmacological studies. At the end of the trial study, majority of the cases showed good results. The clinical study on Raththa moolam with reference to its aetiology, symptomatology, treatment and prognosis were carried out of out patient and in patient wards of post graduate department of maruthuvam. Twenty cases were selected from out patient department and treated in the inpatient ward. Another twenty patients were treated as out-patients. All the patients were treated with Raththa moola Nei 4 gm BD The results were found to be very good in almost every cases. There was marked improvement within two days of treatment. There was good relief with in three to five days in mild cases. In moderate cases good relief was found within 10 – 15 days of treatment. In longstanding cases fair results were found within 20-30 days of treatment. All the In-patients cases were followed in the o.p after discharge. None of the cases reported for recurrence during the clinical study. No side effects were observed clinically in any of these cases during the course of treatment. All the drugs were put to use after careful purification process laid down for them individually. Ethical war of purification for every raw drug were followed as mention in the Siddha Literatures before the process of preparation. The trial drugs were found to correct the deranged three humours thereby correcting abana, prana vayus, pithams such as anal,ranjaga, prasaga, sathaga, alosaga pithams and the vitiated kabam were relieved from constipation, irritation and anxiety. After the treatment appetite become normal. Phamacological studies showed that the trial drugs Raththa Moola Neiand Pathai legiyam had Syptic and anti-inflammatory actions

Management of renal cell carcinoma with solitary metastasis

BACKGROUND: Distant metastasis are common in Renal cell carcinoma (RCC) nearly one forth of the patients have metastasis at presentation while another 50% develop metastasis during the follow-up. A small percentage of these are solitary metastasis. We describe survival after surgical excision or radiotherapy of solitary metastatic lesion from renal cell carcinoma PATIENTS AND METHODS: Between 1988–2001, 43 patients with solitary metastasis to different sites from renal cell carcinoma underwent either surgical excision or radiotherapy were analyzed. The solitary nature of the lesions was confirmed by investigations. All patients have had radical nephrectomy for the primary lesion. Survival analysis was carried out by Kaplan Meier Method. RESULTS: All solitary metastatic lesions were treated with intent of cure either by excision or radiotherapy. Of these, 13 patients had solitary metastasis at the time of presentation in whom 3-year overall median survival was 26 months. The survival of those who developed solitary metastases during follow-up after nephrectomy for primary was 45 months. The patients with long interval between diagnosis and development of metastasis, early stage and low grade of the primary tumor had better prognosis. CONCLUSION: Complete resection of either synchronous or metachronous solitary metastases from renal cell carcinoma is justified and can contribute to a long-term survival in this select group of patients

Cascaded multicavity resonantly enhanced Mach-Zehnder modulator

Abstract—A resonantly enhanced modulator structure with cascaded multiple resonant cavities is proposed and analyzed. The microwave effective index of the electrode can be much higher than the optical index. Therefore, the electrode structure can be optimized for high modulation efficiency and high resonant enhancement. I

Microwave-Assisted Synthesis of N-Substituted Maleimide Derivatives as Exogenous Antioxidant Agents

A series of N-substituted maleimide derivatives have been developed via acetic acid-mediated microwave reaction pathway, which was identified as the incomparable method for this maleimide compounds. All the synthesized compounds were tested for antioxidant activity by DPPH and H 2 O 2 methods. Compounds 5h and 5m were displayed with higher antioxidant activity in two methods. The structure–activity relationship demonstrated that the compounds having electron releasing substitutions 5h and 5m generally show beneficial activity than electron capture substitution cores. Thus, compounds 5h and 5m may be useful as an exogenous antioxidant. © 2018 Wiley Periodicals, Inc

Removal of Acid Blue25 from aqueous solutions using Bengal gram fruit shell (BGFS) biomass

The feasibility for the removal of Acid Blue25 (AB25) by Bengal gram fruit shell (BGFS), an agricultural by-product, has been investigated as an alternative for high-cost adsorbents. The impact of various experimental parameters such as dose, different dye concentration, solution pH, and temperature on the removal of Acid Blue25 (AB25) has been studied under the batch mode of operation. pH is a significant impact on the sorption of AB25 onto BGFS. The maximum removal of AB25 was achieved at a pH of 2 (83.84%). The optimum dose of biosorbent was selected as 200mg for the removal of AB25 onto BGFS. Kinetic studies reveal that equilibrium reached within 180minutes. Biosorption kinetics has been described by Lagergren equation and biosorption isotherms by classical Langmuir and Freundlich models. Equilibrium data were found to fit well with the Langmuir and Freundlich models, and the maximum monolayer biosorption capacity was 29.41mg g(-1) of AB25 onto BGFS. The kinetic studies indicated that the pseudo-second-order (PSO) model fitted the experimental data well. In addition, thermodynamic parameters have been calculated. The biosorption process was spontaneous and exothermic in nature with negative values of Delta G degrees (-1.6031 to -0.1089kJ mol(-1)) and Delta H degrees (-16.7920kJ mol(-1)). The negative G degrees indicates the feasibility of physical biosorption process. The results indicate that BGFS could be used as an eco-friendly and cost-effective biosorbent for the removal of AB25 from aqueous solution

Organic field-effect transistor-based flexible sensors

Flexible electronic devices have attracted a great deal of attention in recent years due to their flexibility, reduced complexity and lightweight. Such devices can conformably attach themselves to any bendable surface and can possess diverse transduction mechanisms. Consequently, with continued emphasis on innovation and development, major technological breakthroughs have been achieved in this area. This review focuses on the advancements of using organic field-effect transistors (OFETs) in flexible electronic applications in the past 10 years. In addition, to the above mentioned features, OFETs have multiple advantages such as low-cost, readout integration, large-area coverage, and power efficiency, which yield synergy. To begin with, we have introduced organic semiconductors (OSCs), followed by their applications in various device configurations and their mechanisms. Later, the use of OFETs in flexible sensor applications is detailed with multiple examples. Special attention is paid to discussing the effects induced on physical parameters of OFETs with respect to variations in external stimuli. The final section provides an outlook on the mechanical aspects of OSCs, activation and revival processes of sensory layers, small area analysis, and pattern recognition techniques for electronic devices

An efficient and green approach: One pot, multi component, reusable catalyzed synthesis of pyranopyrazoles and investigation of biological assays

An ecofriendly itinerary for the synthesis of pyranopyrazole derivatives having thioether link has been established via reusable, green catalyst, green solvent and multicomponent domino approach. To avoid impurities, usage of toxic solvents, toxic catalyst, simple workup and quantitative yields were strategies of this method. In addition, all the reported compounds were tested for their antioxidant and antibacterial properties. Some compounds displayed higher antioxidant activity than the standard drug (6a and 6j), while some other active compounds showed prominent antibacterial activity (6e and 6n). The results demonstrated that these active compounds may be used to support as a decent stand for further investigation in a way to ascertain innovative antioxidant and antibacterial medicines. Keywords: Green synthesis, Ecofriendly solvent, Pyranopyrazoles, Antioxidant, Antibacteria