Long-term exposure to road traffic noise and incident heart failure: evidence from UK Biobank

Background Evidence on road traffic noise and heart failure (HF) is limited, and little is known on the potential mediation roles of acute myocardial infarction (AMI), hypertension, or diabetes. Objectives The purpose of this study was to evaluate the impacts of long-term road traffic noise exposure on the risk of incident HF considering air pollution, and explore the mediations of the previously mentioned diseases. Methods This prospective study included 424,767 participants without HF at baseline in UK Biobank. The residential-level noise and air pollution exposure was estimated, and the incident HF was identified through linkages with medical records. Cox proportional hazard models were used to estimate HRs. Furthermore, time-dependent mediation was performed. Results During a median 12.5 years of follow-up, 12,817 incident HF were ascertained. The HRs were 1.08 (95% CI: 1.00-1.16) per 10 dB[A] increase in weighted average 24-hour road traffic noise level (Lden), and 1.15 (95% CI: 1.02-1.31) for exposure to Lden >65dB[A] compared with the reference category (Lden ≤55dB[A]), respectively. Furthermore, the strongest combined effects were found in those with both high exposures to road traffic noise and air pollution including fine particles and nitrogen dioxide. Prior AMI before HF within 2 years’ time interval mediated 12.5% of the association of road traffic noise with HF. Conclusions More attention should be paid and a preventive strategy should be considered to alleviate the disease burden of HF related to road traffic noise exposure, especially in participants who survived AMI and developed HF within 2 years

Giant enhancement of higher-order harmonics of an optical-tweezer phonon laser

Phonon lasers, as mechanical analogues of optical lasers, are unique tools for not only fundamental studies of phononics but also diverse applications such as acoustic imaging and force sensing. Very recently, by levitating a micro-size sphere in an optical tweezer, higher-order mechanical harmonics were observed in the phonon-lasing regime, as the first step towards nonlinear levitated optomechanics [Nat. Phys. 19, 414 (2023)]. However, both the lasing strengths and the quality factors of the observed harmonics are typically very low, thus severely hindering their applications. Here we show that, by applying a simple but powerful electronic control to such a levitated micro-sphere, three orders of magnitude enhancement are achievable in the brightness of the phonon lasers, including both the fundamental mode and all its higher-order harmonics. Also, giant improvements of their linewidth and frequency stability are realized in such an electro-optomechanical system, together with further improved higher-order phonon coherence. These results, as a significant step forward for enhancing and controlling micro-object phonon lasers, can be readily used for a wide range of applications involving nonlinear phonon lasers, such as acoustic frequency comb, ultra-sound sensing, atmospherical monitoring, and even bio-medical diagnosis of levitated micro-size objects.Comment: 15 pages, 4 figure

Reliability sequential compliance method for a partially observable gear system subject to vibration monitoring

Assumptions accompanying exponential failure models are often not met in the standard sequential probability ratio test (SPRT) of many products. However, for most of the mechanical products, Weibull distribution conforms to their life distributions better compared to other techniques. The SPRT method for Weibull life distribution is derived in this paper, which enables the implementation of reliability compliance tests for gearboxes. Using historical failure data and condition monitoring data, a life prediction model based on hidden Markov model (HMM) is established to describe the deterioration process of gearboxes, then the predicted remaining useful life (RUL) is transformed into failure data that is used in SPRT for further analysis, which can significantly save on testing time and reduce costs. Explicit expression for the distribution of RUL is derived in terms of the posterior probability that the system is in the unhealthy state. The predicted and actual values of the residual life are compared, and the average relative error is 3.90 %, which verifies the validity of the proposed residual life prediction approach. A comparison with other life prediction and SPRT methods is given to elucidate the efficacy of the proposed approach

Arctic weather routing: a review of ship performance models and ice routing algorithms

With the accelerated melting of the Arctic sea ice, the opening of the Northeast Passage of the Arctic is becoming increasingly accessible. Nevertheless, the constantly changing natural environment of the Arctic and its multiple impacts on vessel navigation performance have resulted in a lack of confidence in the outcomes of polar automated route planning. This paper aims to evaluate the effectiveness of two distinct models by examining the advancements in two essential components of e-navigation, namely ship performance methods and ice routing algorithms. We also seek to provide an outlook on the future directions of model development. Furthermore, through comparative experiments, we have examined the existing research on ice path planning and pointed out promising research directions in future Arctic Weather Routing research

Identification, molecular evolution, codon bias, and expansion analysis of NLP transcription factor family in foxtail millet (Setaria italica L.) and closely related crops

The NODULE-INCEPTION-like protein (NLP) family is a plant-specific transcription factor (TF) family involved in nitrate transport and assimilation in plants, which are essential for improving plant nitrogen use efficiency. Currently, the molecular nature and evolutionary trajectory of NLP genes in the C4 model crop foxtail millet are unknown. Therefore, we performed a comprehensive analysis of NLP and molecular evolution in foxtail millet by scanning the genomes of foxtail millet and representative species of the plant kingdom. We identified seven NLP genes in the foxtail millet genome, all of which are individually and separately distributed on different chromosomes. They were not structurally identical to each other and were mainly expressed on root tissues. We unearthed two key genes (Si5G004100.1 and Si6G248300.1) with a variety of excellent characteristics. Regarding its molecular evolution, we found that NLP genes in Gramineae mainly underwent dispersed duplication, but maize NLP genes were mainly generated via WGD events. Other factors such as base mutations and natural selection have combined to promote the evolution of NLP genes. Intriguingly, the family in plants showed a gradual expansion during evolution with more duplications than losses, contrary to most gene families. In conclusion, this study advances the use of NLP genetic resources and the understanding of molecular evolution in cereals

Review on the roles of specific cell-derived exosomes in Alzheimer's disease

Alzheimer's disease (AD) is the sixth leading cause of death worldwide and cannot be effectively cured or prevented; thus, early diagnosis, and intervention are important. The importance of exosomes, membrane-bound extracellular vesicles produced in the endosome of eukaryotic cells, in the development, diagnosis, and treatment of AD has been recognized; however, their specific functions remain controversial and even unclear. With the development of exosome extraction, isolation, and characterization, many studies have focused on exosomes derived from different cells and body fluids. In this study, we summarized the roles of exosomes derived from different body fluids and cells, such as neuron, glial, stem, and endothelial cells, in the development, diagnosis, monitoring, and treatment of AD. We also emphasize the necessity to focus on exosomes from biological fluids and specific cells that are less invasive to target. Moreover, aside from the concentrations of classic and novel biomarkers in exosomes, the size and number of exosomes may also influence early and differential diagnosis of AD