Effects of Low Dose Radiation on Mammals 1

Radiation has been applied widely to clinics, researches and industries nowadays. Irradiation by atomic bomb produced many victims in Hiroshima and Nagasaki. Radiation effects on animals and human belings have been reported extensively, especially at a dose range of high amount of radiation. As radiation effects at low dose have not been well studied, it is believed that even a small amount of radiation produces hazardous effects. However, it might not be true. Beneficial effects of a low dose of radiation are summarized here

Effects of the Atomic Bomb Explosion in Nagasaki : A Medical Perspective 1

A review of the medical effects of the Nagasaki atomic bomb explosion encountered between 1945 and 1990 was conducted. In the early stage, severe and various manifestations due to a combination of heat rays, blast and radiation were detected, but the accurate number of deaths among victims during this early period remains obscure. Keloid scars, cataract, leukemia, thyroid cancer, breast cancer and lung cancer have been established as diseases related to the atomic bomb explosion. Recent epidemiologic investigations show that the incidence of other diseases such as gastric cancer and skin cancer are also relatively high among atomic bomb survivors in Nagasaki

Mortality of Atomic Bomb Survivors in Nagasaki 1

In 1945, an atomic bomb was exploded on Nagasaki. The Scientific Data Center for the Atomic Bomb Disaster was founded in Nagasaki University to analyse radiation effects on atomic bomb survivors. There were about 110,000 victims registered living in Nagasaki as of 1968. Since then, data of 2,000,000 items of health examination has been stored in the computer in the Scientific Data Center. The analysed results of the mortality, the survival and the risk estimation were presented

Storing Medical Records of A-Bomb Survivors on Optical Disks

Medical records of A-bomb survivors include numerical data and non-numerical data such as handwritten description. We have been storing the numerical data in medical records into a data base. We started to store the nonnumerical data on optical disks. We analyzed the significance and usefulness of storing them. The nonnumerical data of symptoms can not be evaluated by but can be analyzed with the numerical data. It was concluded that storing non-numerical data in the medical records on the optical disks would be worthy

Death Rate of Survivors in Nagasaki at Early Time of A-Bomb Explosion

The death rate of survivors at early time after A-bomb explosion was analyzed with the A-bomb disaster survey in Nagasaki city. Survivors who were alive September 1st, 1945 was 20,746 persons, in which 17,869 persons (86.1%) had information for the analysis. The death rate in 1945 of survivors exposed in their houses at less than 1,199 m from the hypocenter was higher than those exposed not in their houses. The death rate of survivors in 1946 decreased rapidly, although that of survivors exposed at less than 1,199 m from the hypocenter was still high

Factors Determining Satisfaction with Daily Life of Elderly A-bomb Survivors

From the analysis of questionnaires to elderly A-bomb survivors of over 65 years old, we analysed factors which determined satisfaction with daily life. Analysed categories were housing condition, life style, occupational status, health condition and family status. From the analysis, to be an A-bomb survivor was not a factor for satisfaction with daily life, and it became clear that living in a rented room, not satisfying one\u27s job and low income were serious factors which kept elderly people from the satisfaction with daily life. It must be necessary to improve these factors for the satisfaction of elderly people

Changes of Concentrations of Free Amino Acids in HeLa Cells Induced by Antitumor Agent

In this report we have investigated that the amino acid is most actively metabolized in the tumor cells damaged by antitumor agents, and discussed imbalanced amino acid procedure to be combined with cancer chemotherapy. The concentrations of 24 free amino acids in medium and in cells were determined in HeLa cells treated with Adriamycin. The free amino acids that decreased in the medium but increased in cells were glutamine and arginine. From this result, we treated HeLa cells with Adriamycin in medium of glutamine-deficiency and obtained a marked cytocidal effect. It would be difficult to make tumor tissues of glutamine-depletion in the whole body. For clinical application, local administration such as intraarterial infusion of L-glutamine antagonists combined with antitumor agents is expected as a practical administration method