Stereoselective Construction of 2,7-Disubstituted <i>fused</i>-Bis Tetrahydrofuran Skeletons: Biomimetic-Type Synthesis and Biological Evaluation of (±)- and (−)-Aplysiallene and Their Derivatives

A series of <i>trans</i>/<i>trans</i> and <i>cis</i>/<i>cis</i> <i>fused</i>-bis tetrahydrofuran compounds have been obtained stereoselectively in high yields via a one-pot operation involving the intramolecular haloetherification of (<i>Z</i>,<i>Z</i>)-diene diol <b>19a</b> and (<i>E</i>,<i>E</i>)-diene disilylether <b>19d</b>, respectively. This method was subsequently applied to the biomimetic-type synthesis of (±)- and (−)-aplysiallene. The inhibitory activities of these compounds and their bromodiene isomers toward Na⁺/K⁺ ATPase were determined in vitro, and gave IC₅₀ values of approximately 15 μM in all cases

Baseline characteristics, medications, angiographic and procedural characteristics during the index hospitalization in the propensity score-matched cohort.

(DOCX)</p

Kaplan-Meier event curves for clinical outcomes in patients with two-vessel or three-vessel disease including proximal LAD.

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Angiographic and procedural characteristics: PCI group versus CABG group.

Angiographic and procedural characteristics: PCI group versus CABG group.</p

Fig 2 -

Crude kaplan-meier curves for the cumulative incidence of (A) all-cause death/MI/stroke, (B) all-cause death, (C) any coronary revascularization, and (D) all-cause death/MI/stroke/any coronary revascularization. PCI = percutaneous coronary intervention; CABG = coronary artery bypass grafting; MI = myocardial infarction.</p

List of clinical research coordinators.

(DOCX)</p

Subgroup analyses for the primary outcome measure (death/MI/stroke).

Subgroup analyses for the primary outcome measure (death/MI/stroke).</p

Clinical outcomes: PCI group versus CABG group in patients with two-vessel disease who underwent multi-vessel revascularization including LAD.

(DOCX)</p

Kaplan-Meier event curves for clinical outcomes in patients with two-vessel disease including LAD.

(TIF)</p

Baseline characteristics and medications during the index hospitalization: PCI group versus CABG group.

Baseline characteristics and medications during the index hospitalization: PCI group versus CABG group.</p