Variability in Near-Surface Ultraviolet Radiation and Its Dependence on Atmospheric Parameters

Natural radiations such as ultraviolet (UV) radiation sourced from sun are known to be the main causes of skin cancer, sunburn, eye damage, premature aging of skin and other skin related diseases. Its percentage of radiation reaching the earth populace and its impacts are not well known. Its variability in near-surface relating to its impacts on populace depends on some atmospheric parameters. Hence, this work was embarked on to determine the variability in near-surface UV radiation and its dependency on some atmospheric parameters at different time of the day in Offa, Nigeria. The variability was determined using the data obtained from meteorological garden, Science Laboratory Technology Department, Federal Polytechnic Offa, Nigeria. The data obtained were solar UV radiation, solar radiation, temperature, humidity and pressure at 30 minutes interval. Relationships were determined and correlations were derived using SPSS Pearson Correlation tool. The results showed a significant level of correlation with p-value of 0.01 and 0.05 levels. Thus, the results revealed some good relationships between the solar UV radiation and other atmospheric parameters with significance level less than p-value obtained. Inferentially, interdependent relationships were found to exist. Therefore, the nature of relationship obtained could be a yardstick for decision making in short term environmental planning on solar UV radiation depending of some atmospheric parameters within Offa locality

The Effectiveness of Using Application as An Online Basic Computer Learning Medium in Higher Education Institution

The use of Google Meet (GM) application for teaching and learning implementation online is one of the methods in the teaching manual that has been introduced by the Ministry of Higher Education (MOHE). This study aimed to identify the level of readiness of students and self-motivation by students when using the GM application as a medium for online learning Basic Computer subject in Higher Education Institution during pandemic Covid-19. A quantitative study was conducted with the participation of 43 students from Diploma level in Universiti Islam Antarabangsa Sultan Abdul Halim Mu’adzam Shah (UniSHAMS). A set of questionnaires had been provided with three main categories consists of Online Learning Medium, Online Learning Method Using Application, and Relationship Between Online Learning Application’s Features with Self-Motivation. The findings of this study show that Online Learning Medium improves self-motivation and directly encourages students to adopt technology into their learning. Furthermore, learning application directly affects their self-motivation. Online learning medium, as mediated by online learning application, can affect self-motivation. The results suggested that MOHE must encourage the use of online learning application for teaching and learning in their schools to align with the technology growth rapidly

Amphiphilic Molecules Exhibiting Zwitterionic Excited-State Intramolecular Proton Transfer and Near-Infrared Emission for the Detection of Amyloid β Aggregates in Alzheimer’s Disease

Chromophores with zwitterionic excited-state intramolecular proton transfer (ESIPT) have been shown to have larger Stock shifts and red-shifted emission wavelengths compared to the conventional π-delocalized ESIPT molecules. However, there is still a dearth of design strategies to expand the current library of zwitterionic ESIPT compounds. Herein, we report a novel zwitterionic excited-state intramolecular proton transfer system enabled by addition of triazamacrocycle (TACN) fragments on a dicyanomethylene-4H-pyran (DCM) scaffold. The solvent-dependent steady-state photophysical studies and pKa measurements strongly support that the ESIPT process is more efficient with two TACN groups attached to the DCM scaffold and not affected by polar protic solvents. Impressively, compound DCM-OH-2-DT emits with a near-infrared (NIR) emission wavelength at 740 nm along with an uncommonly large Stokes shift of ~ 280 nm. Moreover, DCM-OH-2-DT shows high affinity towards soluble amyloid β (Aβ) oligomers in vitro and in 5xFAD mouse brain sections, and we have successfully applied DCM-OH-2-DT for the NIR fluorescence in vivo imaging of Aβ aggregates and demonstrated its potential use as an early diagnostic agent for AD. Overall, this study can provide a general molecular design strategy for developing new zwitterionic ESIPT compounds with NIR emission for further in vivo imaging applications