Simulating large-size quantum spin chains on cloud-based superconducting quantum computers

Quantum computers have the potential to efficiently simulate large-scale quantum systems for which classical approaches are bound to fail. Even though several existing quantum devices now feature total qubit numbers of more than one hundred, their applicability remains plagued by the presence of noise and errors. Thus, the degree to which large quantum systems can successfully be simulated on these devices remains unclear. Here, we report on cloud simulations performed on several of IBM's superconducting quantum computers to simulate ground states of spin chains having a wide range of system sizes up to one hundred and two qubits. We find that the ground-state energies extracted from realizations across different quantum computers and system sizes reach the expected values to within errors that are small (i.e. on the percent level), including the inference of the energy density in the thermodynamic limit from these values. We achieve this accuracy through a combination of physics-motivated variational Ansatzes, and efficient, scalable energy-measurement and error-mitigation protocols, including the use of a reference state in the zero-noise extrapolation. By using a 102-qubit system, we have been able to successfully apply up to 3186 CNOT gates in a single circuit when performing gate-error mitigation. Our accurate, error-mitigated results for random parameters in the Ansatz states suggest that a standalone hybrid quantum-classical variational approach for large-scale XXZ models is feasible.Comment: 21 pages, 12 figures, 4 tables; title change; substantial revisio

An Automatic Evaluation Framework for Multi-turn Medical Consultations Capabilities of Large Language Models

Large language models (LLMs) have achieved significant success in interacting with human. However, recent studies have revealed that these models often suffer from hallucinations, leading to overly confident but incorrect judgments. This limits their application in the medical domain, where tasks require the utmost accuracy. This paper introduces an automated evaluation framework that assesses the practical capabilities of LLMs as virtual doctors during multi-turn consultations. Consultation tasks are designed to require LLMs to be aware of what they do not know, to inquire about missing medical information from patients, and to ultimately make diagnoses. To evaluate the performance of LLMs for these tasks, a benchmark is proposed by reformulating medical multiple-choice questions from the United States Medical Licensing Examinations (USMLE), and comprehensive evaluation metrics are developed and evaluated on three constructed test sets. A medical consultation training set is further constructed to improve the consultation ability of LLMs. The results of the experiments show that fine-tuning with the training set can alleviate hallucinations and improve LLMs' performance on the proposed benchmark. Extensive experiments and ablation studies are conducted to validate the effectiveness and robustness of the proposed framework.Comment: 10 pages, 9figure

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter.

Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a profound effect on stimulating Telomerase activity in hematopoietic cells. Here, the mechanism of TSY-1 on cellular Telomerase activity was further investigated using HL60, a promyelocytic leukemia cell line, normal peripheral blood mononuclear cells, and CD34+ hematopoietic stem cells derived from umbilical cord blood. TSY-1 increases Telomerase activity in normal peripheral blood mononuclear cells and CD34+ hematopoietic stem cells with innately low Telomerase activity but decreases Telomerase activity in HL60 cells with high intrinsic Telomerase activity, both in a dose-response manner. Gene profiling analysis identified Telomerase reverse transcriptase (TERT) as the potential target gene associated with the TSY-1 effect, which was verified by both RT-PCR and western blot analysis. The β-galactosidase reporter staining assay showed that the effect of TSY-1 on Telomerase activity correlates with cell senescence. TSY-1 induced hypomethylation within TERT core promoter in HL60 cells but induced hypermethylation within TERT core promoter in normal peripheral blood mononuclear cells and CD34+ hematopoietic stem cells. TSY-1 appears to affect the Telomerase activity in different cell lines differently and the effect is associated with TERT expression, possibly via the methylation of TERT promoter

Room-temperature antiferromagnetic CrSe monolayer with tunable metal-insulator transition in ferroelectric heterostructures

Recently, there has been a rapidly growing interest in two-dimensional (2D) transition metal chalcogenide monolayers (MLs) due to their unique magnetic and electronic properties. By using an evolutionary algorithm and first-principles calculations, we report the discovery of a previously unexplored, chemically, energetically, and thermodynamically stable 2D antiferromagnetic (AFM) CrSe ML with a N\'eel temperature higher than room temperature. Remarkably, we predict an electric field-controllable metal-insulator transition (MIT) in a van der Waals (vdW) heterostructure comprised of CrSe ML and ferroelectric Sc2CO2. This tunable transition in CrSe/Sc2CO2 heterostructure is attributed to the change in the band alignment between CrSe and Sc2CO2 caused by the ferroelectric polarization reversal in Sc2CO2. Our findings suggest that 2D AFM CrSe ML has important potential applications in AFM spintronics, particularly in the gate voltage conducting channel.Comment: 13 Pages, 4 Figure

ReSup: Reliable Label Noise Suppression for Facial Expression Recognition

Because of the ambiguous and subjective property of the facial expression recognition (FER) task, the label noise is widely existing in the FER dataset. For this problem, in the training phase, current FER methods often directly predict whether the label of the input image is noised or not, aiming to reduce the contribution of the noised data in training. However, we argue that this kind of method suffers from the low reliability of such noise data decision operation. It makes that some mistakenly abounded clean data are not utilized sufficiently and some mistakenly kept noised data disturbing the model learning process. In this paper, we propose a more reliable noise-label suppression method called ReSup (Reliable label noise Suppression for FER). First, instead of directly predicting noised or not, ReSup makes the noise data decision by modeling the distribution of noise and clean labels simultaneously according to the disagreement between the prediction and the target. Specifically, to achieve optimal distribution modeling, ReSup models the similarity distribution of all samples. To further enhance the reliability of our noise decision results, ReSup uses two networks to jointly achieve noise suppression. Specifically, ReSup utilize the property that two networks are less likely to make the same mistakes, making two networks swap decisions and tending to trust decisions with high agreement. Extensive experiments on three popular benchmarks show that the proposed method significantly outperforms state-of-the-art noisy label FER methods by 3.01% on FERPlus becnmarks. Code: https://github.com/purpleleaves007/FERDenois

bpftime: userspace eBPF Runtime for Uprobe, Syscall and Kernel-User Interactions

In kernel-centric operations, the uprobe component of eBPF frequently encounters performance bottlenecks, largely attributed to the overheads borne by context switches. Transitioning eBPF operations to user space bypasses these hindrances, thereby optimizing performance. This also enhances configurability and obviates the necessity for root access or privileges for kernel eBPF, subsequently minimizing the kernel attack surface. This paper introduces bpftime, a novel user-space eBPF runtime, which leverages binary rewriting to implement uprobe and syscall hook capabilities. Through bpftime, userspace uprobes achieve a 10x speed enhancement compared to their kernel counterparts without requiring dual context switches. Additionally, this runtime facilitates the programmatic hooking of syscalls within a process, both safely and efficiently. Bpftime can be seamlessly attached to any running process, limiting the need for either a restart or manual recompilation. Our implementation also extends to interprocess eBPF Maps within shared memory, catering to summary aggregation or control plane communication requirements. Compatibility with existing eBPF toolchains such as clang and libbpf is maintained, not only simplifying the development of user-space eBPF without necessitating any modifications but also supporting CO-RE through BTF. Through bpftime, we not only enhance uprobe performance but also extend the versatility and user-friendliness of eBPF runtime in user space, paving the way for more efficient and secure kernel operations