40 research outputs found
-optimal designs for second-order response surface models
-optimal experimental designs for a second-order response surface model
with predictors are investigated. If the design space is the
-dimensional unit cube, Galil and Kiefer [J. Statist. Plann. Inference 1
(1977a) 121-132] determined optimal designs in a restricted class of designs
(defined by the multiplicity of the minimal eigenvalue) and stated their
universal optimality as a conjecture. In this paper, we prove this claim and
show that these designs are in fact -optimal in the class of all approximate
designs. Moreover, if the design space is the unit ball, -optimal designs
have not been found so far and we also provide a complete solution to this
optimal design problem. The main difficulty in the construction of -optimal
designs for the second-order response surface model consists in the fact that
for the multiplicity of the minimum eigenvalue of the "optimal information
matrix" is larger than one (in contrast to the case ) and as a consequence
the corresponding optimality criterion is not differentiable at the optimal
solution. These difficulties are solved by considering nonlinear Chebyshev
approximation problems, which arise from a corresponding equivalence theorem.
The extremal polynomials which solve these Chebyshev problems are constructed
explicitly leading to a complete solution of the corresponding -optimal
design problems.Comment: Published in at http://dx.doi.org/10.1214/14-AOS1241 the Annals of
Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical
Statistics (http://www.imstat.org
Absorption of Scintillation Light in a 100 Liquid Xenon Ray Detector and Expected Detector Performance
An 800L liquid xenon scintillation ray detector is being developed
for the MEG experiment which will search for decay
at the Paul Scherrer Institut. Absorption of scintillation light of xenon by
impurities might possibly limit the performance of such a detector. We used a
100L prototype with an active volume of 372x372x496 mm to study the
scintillation light absorption. We have developed a method to evaluate the
light absorption, separately from elastic scattering of light, by measuring
cosmic rays and sources. By using a suitable purification technique,
an absorption length longer than 100 cm has been achieved. The effects of the
light absorption on the energy resolution are estimated by Monte Carlo
simulation.Comment: 18 pages, 10 figures (eps). Submitted to Nucl. Instr. and Meth.
Azimuthal anisotropy at RHIC: the first and fourth harmonics
We report the first observations of the first harmonic (directed flow, v_1),
and the fourth harmonic (v_4), in the azimuthal distribution of particles with
respect to the reaction plane in Au+Au collisions at the Relativistic Heavy Ion
Collider (RHIC). Both measurements were done taking advantage of the large
elliptic flow (v_2) generated at RHIC. From the correlation of v_2 with v_1 it
is determined that v_2 is positive, or {\it in-plane}. The integrated v_4 is
about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8)
harmonics upper limits on the magnitudes are reported.Comment: 6 pages with 3 figures, as accepted for Phys. Rev. Letters The data
tables are at
http://www.star.bnl.gov/central/publications/pubDetail.php?id=3
Mid-rapidity anti-proton to proton ratio from Au+Au collisions at GeV
We report results on the ratio of mid-rapidity anti-proton to proton yields
in Au+Au collisions at \rts = 130 GeV per nucleon pair as measured by the
STAR experiment at RHIC. Within the rapidity and transverse momentum range of
and 0.4 1.0 GeV/, the ratio is essentially independent of
either transverse momentum or rapidity, with an average of for minimum bias collisions. Within errors, no
strong centrality dependence is observed. The results indicate that at this
RHIC energy, although the -\pb pair production becomes important at
mid-rapidity, a significant excess of baryons over anti-baryons is still
present.Comment: 5 pages, 3 figures, accepted by Phys. Rev. Let
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial
More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369
Notes for genera: basal clades of Fungi (including Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota)
Compared to the higher fungi (Dikarya), taxonomic and evolutionary studies on the basal clades of fungi are fewer in number. Thus, the generic boundaries and higher ranks in the basal clades of fungi are poorly known. Recent DNA based taxonomic studies have provided reliable and accurate information. It is therefore necessary to compile all available information since basal clades genera lack updated checklists or outlines. Recently, Tedersoo et al. (MycoKeys 13:1--20, 2016) accepted Aphelidiomycota and Rozellomycota in Fungal clade. Thus, we regard both these phyla as members in Kingdom Fungi. We accept 16 phyla in basal clades viz. Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota. Thus, 611 genera in 153 families, 43 orders and 18 classes are provided with details of classification, synonyms, life modes, distribution, recent literature and genomic data. Moreover, Catenariaceae Couch is proposed to be conserved, Cladochytriales Mozl.-Standr. is emended and the family Nephridiophagaceae is introduced
A Unified Approach to Second Order Optimality Criteria in Nonlinear Design of Experiments
D-optimal design, nonlinear regression model, second order approximation, asymptotic expansion,
The Placement of Four Short Implants and Full-Arch Early Loading in the Edentulous Patient Suffering from Severe Mandibular Alveolar Ridge Atrophy
One of the treatments of patients with severe bone atrophy is short implants. It is important to position short implants taking into account the prosthetic loading and right position according to vital anatomical structures. In the presented case report, a seventy-one-year-old female patient underwent the rehabilitation with four short dental implants placed in the anterior mandibula with fully guided surgery to avoid mandibular incisive canal. It solves all the problems in the planning stage when you determine the osteotomy protocol in advance and the prognosis of future restoration according to patient requirements. This clinical case demonstrates the efficiency of patient rehabilitation with the use of short implants in difficult clinical situations