61 research outputs found
Monte Carlo simulation of EAS generated by 10(14) - 10(16) eV protons
Detailed Monte Carlo simulations of extensive air showers to be detected by the Homestake Surface Underground Telescope and other similar detectors located at sea level and mountain altitudes have been performed for 10 to the 14th power to 10 to the 16th power eV primary energies. The results of these Monte Carlo calculations will provide an opportunity to compare the experimental data with different models for the composition and spectra of primaries and for the development of air showers. The results obtained for extensive air showers generated by 10 to the 14th power to 10 to the 16th power eV primary protons are reported
Driver Accelerator Design for the 10 kW Upgrade of the Jefferson Lab IR FEL
An upgrade of the Jefferson Lab IR FEL is now under construction. It will
provide 10 kW output light power in a wavelength range of 2-10 microns. The FEL
will be driven by a modest-sized 80-210 MeV, 10 mA energy-recovering
superconducting RF (SRF) linac. Stringent phase space requirements at the
wiggler, low beam energy, and high beam current subject the design to numerous
constraints. These are imposed by the need for both transverse and longitudinal
phase space management, the potential impact of collective phenomena (space
charge, wakefields, beam break-up (BBU), and coherent synchrotron radiation
(CSR)), and interactions between the FEL and the accelerator RF system. This
report addresses these issues and presents an accelerator design solution
meeting the requirements imposed by physical phenomena and operational
necessities.Comment: submission THC03 for LINAC200
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Resolve at CEBAF
M. Lee's program RESOLVE has recently been in extensive use at CEBAF to help identify and correct optics problems in recirculation arcs and in linac beamlines encountered during the commissioning of the 4-GeV accelerator. The authors describe the integration of the program with their machine applications software package. A significant vertical focusing error in one of the recirculation arcs, which is attributed to edge focusing of dipole magnets, was found from the analysis of difference orbit measurement data. A corrective measure has been successfully implemented. Optics checks in the spreader and recombiner regions are discussed along with linac optics and 60Hz jitter. 7 refs., 4 figs
Beam-Breakup Instability Theory for Energy Recovery Linacs
Here we will derive the general theory of the beam-breakup instability in
recirculating linear accelerators, in which the bunches do not have to be at
the same RF phase during each recirculation turn. This is important for the
description of energy recovery linacs (ERLs) where bunches are recirculated at
a decelerating phase of the RF wave and for other recirculator arrangements
where different RF phases are of an advantage. Furthermore it can be used for
the analysis of phase errors of recirculated bunches. It is shown how the
threshold current for a given linac can be computed and a remarkable agreement
with tracking data is demonstrated. The general formulas are then analyzed for
several analytically solvable cases, which show: (a) Why different higher order
modes (HOM) in one cavity do not couple so that the most dangerous modes can be
considered individually. (b) How different HOM frequencies have to be in order
to consider them separately. (c) That no optics can cause the HOMs of two
cavities to cancel. (d) How an optics can avoid the addition of the
instabilities of two cavities. (e) How a HOM in a multiple-turn recirculator
interferes with itself. Furthermore, a simple method to compute the orbit
deviations produced by cavity misalignments has also been introduced. It is
shown that the BBU instability always occurs before the orbit excursion becomes
very large.Comment: 12 pages, 6 figure
Science Requirements and Conceptual Design for a Polarized Medium Energy Electron-Ion Collider at Jefferson Lab
This report presents a brief summary of the science opportunities and program
of a polarized medium energy electron-ion collider at Jefferson Lab and a
comprehensive description of the conceptual design of such a collider based on
the CEBAF electron accelerator facility.Comment: 160 pages, ~93 figures This work was supported by the U.S. Department
of Energy, Office of Nuclear Physics, under Contract No. DE-AC05-06OR23177,
DE-AC02-06CH11357, DE-AC05-060R23177, and DESC0005823. The U.S. Government
retains a non-exclusive, paid-up, irrevocable, world-wide license to publish
or reproduce this manuscript for U.S. Government purpose
MEIC Design Progress
This paper will report the recent progress in the conceptual design of MEIC, a high luminosity medium energy polarized ring-ring electron-ion collider at Jefferson lab. The topics and achievements that will be covered are design of the ion large booster and the ERL-circulator-ring-based electron cooling facility, optimization of chromatic corrections and dynamic aperture studies, schemes and tracking simulations of lepton and ion polarization in the figure-8 collider ring, and the beam-beam and electron cooling simulations. A proposal of a test facility for the MEIC electron cooler will also be discussed
The molecular basis of breast cancer pathological phenotypes
The histopathological evaluation of morphological features in breast tumours provides prognostic information to guide therapy. Adjunct molecular analyses provide further diagnostic, prognostic and predictive information. However, there is limited knowledge of the molecular basis of morphological phenotypes in invasive breast cancer. This study integrated genomic, transcriptomic and protein data to provide a comprehensive molecular profiling of morphological features in breast cancer. Fifteen pathologists assessed 850 invasive breast cancer cases from The Cancer Genome Atlas (TCGA). Morphological features were significantly associated with genomic alteration, DNA methylation subtype, PAM50 and microRNA subtypes, proliferation scores, gene expression and/or RPPA subtype. Marked nuclear pleomorphism, necrosis, inflammation and high mitotic count were associated with Basal-like subtype and have similar molecular basis. Omics-based signatures were constructed to predict morphological features. The association of morphology transcriptome signatures with overall survival in oestrogen receptor (ER)-positive and ER-negative breast cancer was first assessed using the METABRIC dataset; signatures that remained prognostic in the METABRIC multivariate analysis were further evaluated in five additional datasets. The transcriptomic signature of epithelial tubule formation was prognostic in ER-positive breast cancer. No signature was prognostic in ER-negative. This study provided new insights into the molecular basis of breast cancer morphological phenotypes. The integration of morphological with molecular data has potential to refine breast cancer classification, predict response to therapy, enhance our understanding of breast cancer biology and improve clinical management. This work is publicly accessible at www.dx.ai/tcga_breast
First lasing of the Jefferson Lab IR Demo FEL
As reported previously [1], Jefferson Lab is building a free-electron laser capable of generating a continuous wave kilowatt laser beam. The driver-accelerator consists of a superconducting, energy-recovery accelerator. The initial stage of the program was to produce over 100 W of average power with no recirculation. In order to provide maximum gain the initial wavelength was chosen to be 5 mu-m and the initial beam energy was chosen to be 38.5 MeV. On June 17, 1998, the laser produced 155 Watts cw power at the laser output with a 98% reflective output coupler. On July 28th, 311 Watts cw power was obtained using a 90% reflective output coupler. A summary of the commissioning activities to date as well as some novel lasing results will be summarized in this paper. Present work is concentrated on optimizing lasing at 5 mu-m, obtaining lasing at 3 mu-m, and commissioning the recirculation transport in preparation for kilowatt lasing this fall
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