Comparison between the influence of roxadustat and recombinant human erythropoietin treatment on blood pressure and cardio-cerebrovascular complications in patients undergoing peritoneal dialysis

IntroductionRoxadustat treatment in PD patients is equivalent to ESAs in increasing hemoglobin (Hb). But blood pressure, cardiovascular parameters, cardio-cerebrovascular complications and prognosis in the two groups before and after treatment has not been sufficiently discussed.MethodsSixty PD patients who were treated with roxadustat for renal anemia in our PD center recruited from June 2019 to April 2020 as roxadustat group. PD patients treated with rHuEPO were enrolled at a 1:1 ratio as rHuEPO group using the method of propensity score matching. Hb, blood pressure, cardiovascular parameters, cardio-cerebrovascular complications and prognosis were compared between the two group. All patients were followed up for at least 24 months.ResultsThere were no significant differences in baseline clinical data or laboratory values between roxadustat group and rHuEPO group. After 24 months of follow-up, there was no significant difference in Hb levels (p > 0.05). There were no significant changes in blood pressure, or the incidence of nocturnal hypertension before and after treatment in roxadustat group (p > 0.05), while blood pressure significantly increased in rHuEPO group after treatment (p < 0.05). Compared with roxadustat group after follow-up, rHuEPO group had a higher incidence of hypertension, the levels of cardiovascular parameters were worse and cardio-cerebrovascular complications had a higher incidence (p < 0.05). Cox regression analysis showed age, systolic blood pressure, fasting blood glucose, and rHuEPO use before baseline were risk factors for cardio-cerebrovascular complications in PD patients, while treatment with roxadustat was a protective factor for cardiovascular and cerebrovascular complications.ConclusionCompared with rHuEPO, roxadustat had less influence on blood pressure or cardiovascular parameters, and it was associated with a lower risk of cardio-cerebrovascular complications in patients undergoing PD. Roxadustat has a cardio-cerebrovascular protective advantage in PD patients with renal anemia

Ultra-thin transmissive crystalline silicon high-contrast grating metasurfaces

Dielectric metasurfaces made from crystalline silicon, titanium dioxide, gallium nitride and silicon nitride have developed rapidly for applications in the visible wavelength regime. High performance metasurfaces typically require the realisation of subwavelength, high aspect ratio nanostructures, the fabrication of which can be challenging. Here, we propose and demonstrate the operation of high performance metasurfaces in ultra-thin (100 nm) crystalline silicon at the wavelength of 532 nm. Using optical beam analysis, we discuss fabrication complexity and show that our approach is more fabrication-tolerant than the nanofin approach, which has so far produced the highest performance metasurfaces, but may be difficult to manufacture, especially when using nanoimprint lithography

Development of a Ten-lncRNA Signature Prognostic Model for Breast Cancer Survival: A Study with the TCGA Database

Long noncoding RNA (lncRNA) plays a critical role in the development of tumors. The aim of our study was construction of a lncRNA signature model to predict breast cancer (BRCA) patient survival. We downloaded RNA-seq data and relevant clinical information from the Cancer Genome Atlas (TCGA) database. Differentially expressed lncRNA were computed using the “edgeR” package and subjected to the univariate and multivariate Cox regression analysis. Corresponding protein-coding genes were used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway analysis. Finally, 521 differentially expression lncRNA were obtained. We constructed a ten-lncRNA signature model (LINC01208, RP5-1011O1.3, LINC01234, LINC00989, RP11-696F12.1, RP11-909N17.2, CTC-297N7.9, CTA-384D8.34, CTC-276P9.4, and MAPT-IT1) to predict BRCA patient survival using the multivariate Cox proportional hazard regression model. The C-index was 0.712, and AUC scores of training, test, and entire sets were 0.746, 0.717, and 0.732, respectively. Univariate Cox regression analysis indicated that age, tumor status, N status, M status, and risk score were significantly related to overall survival in patients with BRCA. Further, the multivariate analysis showed that risk score and M status had outstanding independent prognostic values, both with p<0.001. The Gene Ontology (GO) function and KEEG pathway analysis was primarily enriched in immune response, receptor binding, external surface of plasma membrane, signal transduction, cytokine-cytokine receptor interaction, and cell adhesion molecules (CAMs). Finally, we constructed a ten-lncRNA signature model that can serve as an independent prognostic model to predict BRCA patient survival

Research on the Mechanical Properties and NMR Characteristics of Cement Mortar during Freeze-Thaw Cycles

Low-field nuclear magnetic resonance (NMR) technology has the characteristics of nondestructive, rapid, and accurate. In the present paper, the mechanical properties and the size and distribution of pores of cement mortar during freeze-thaw cycles were studied by using the NMR technology for the first time. The change law of surface and quality, compressive strength, splitting tensile strength, and elastic modulus of cement mortar under 0, 25, 50, 75, and 100 freeze-thaw cycles were studied. And the changes of T2 spectra of cement mortar under different freeze-thaw environments were analyzed; the change rule between freeze-thaw cycles and the size of the pore within the cement mortar were also obtained. Moreover, the relationship between the mechanical properties and the pore structure of cement mortar was studied

Soil disturbance evaluation of soft clay based on stress-normalized small-strain stiffness

Soil disturbance includes the change of stress state and the damage of soil structure. The field testing indices reflect the combined effect of both changes and it is difficult to identify the soil structure disturbance directly from these indices. In the present study, the small-strain shear modulus is used to characterize soil structure disturbance by normalizing the effective stress and void ratio based on Hardin equation. The procedure for evaluating soil sampling disturbance in the field and the further disturbance during the subsequent consolidation process in laboratory test is proposed, and then validated by a case study of soft clay ground. Downhole seismic testing in the field, portable piezoelectric bender elements for the drilled sample and bender elements in triaxial apparatus for the consolidated sample were used to monitor the shear wave velocity of the soil from intact to disturbed and even remolded states. It is found that soil sampling disturbance degree by conventional thin-wall sampler is about 30% according to the proposed procedure, which is slightly higher than that from the modified volume compression method proposed by Hong and Onitsuka (1998). And the additional soil disturbance induced by consolidation in laboratory could reach about 50% when the consolidation pressure is far beyond the structural yield stress, and it follows the plastic volumetric strain quite well

Comparative Analysis of Strength and Deformation Behavior of Cemented Tailings Backfill under Curing Temperature Effect

Mineral resources are increasingly being developed in cold and permafrost regions. However, the mechanical and physical properties of cemented tailings backfill (CTB) cured at normal temperature are no longer applicable. To clarify the reasons for this variability, a series of tests were performed. The mechanical properties of CTB with different cement&ndash;tailings ratios (CTR, 1:4, 1:8, 1:12, 1:16, and 1:20) were tested at different curing ages (3, 7 and 28 days) and curing temperatures (20 &deg;C, 5 &deg;C, &minus;5 &deg;C, and &minus;20 &deg;C). The differences of CTB in mechanical and physical properties under positive- and negative-temperature curing conditions were analyzed, and the microscopic failure process of CTB under negative-temperature curing conditions was discussed. The results revealed that the mechanical properties and deformation behavior of CTB under positive- and negative-temperature curing conditions were different. The frozen CTB had higher early strength than the standard-temperature curing condition (20 &deg;C), and the lower the temperature, the higher the early strength. The low-temperature curing condition, on the other hand, was not beneficial to CTB&rsquo;s long-term strength. The low-temperature curing condition was not conducive to the long-term strength of CTB. After yielding, strain hardening and strain softening appeared in the deformation behavior of frozen backfill, indicating ductility. In contrast to the typical-temperature curing condition, the frozen CTB showed a new failure pattern that has little relation to curing time or CTR. Furthermore, the failure process of frozen backfill was reviewed and studied, which was separated into four stages, and altered as the curing time increased. The results of this study can act as a guide for filling mines in permafrost and cold climates

Study on selenium accumulation characteristics of different ploidies

The selenium accumulation characteristics of Solanum nigrum with different ploidy were studied by the pot experiment, and the biomass, selenium content and selenium accumulation of diploid (Solanum photeinocarpum), tetraploid (Solanum photeinocarpum) and hexaploid (Solanum nigrum) plants were determined, the results showed that there was a difference between the biomass and selenium content of three kinds of ploidy plants of S. nigrum. The biomass of various organs and shoots of hexaploid S. nigrum plants was significantly higher than that of tetraploid and diploid plants. In terms of selenium content and selenium accumulation, the hexaploid plants had the highest selenium content and selenium accumulation in stems, leaves and shoots. After comprehensive comparison, the hexaploid S. nigrum has large biomass and strong selenium-enriching ability, so it can be used as an excellent plant material for soil selenium absorption and transformation