Spikeformer: A Novel Architecture for Training High-Performance Low-Latency Spiking Neural Network

Spiking neural networks (SNNs) have made great progress on both performance and efficiency over the last few years,but their unique working pattern makes it hard to train a high-performance low-latency SNN.Thus the development of SNNs still lags behind traditional artificial neural networks (ANNs).To compensate this gap,many extraordinary works have been proposed.Nevertheless,these works are mainly based on the same kind of network structure (i.e.CNN) and their performance is worse than their ANN counterparts,which limits the applications of SNNs.To this end,we propose a novel Transformer-based SNN,termed "Spikeformer",which outperforms its ANN counterpart on both static dataset and neuromorphic dataset and may be an alternative architecture to CNN for training high-performance SNNs.First,to deal with the problem of "data hungry" and the unstable training period exhibited in the vanilla model,we design the Convolutional Tokenizer (CT) module,which improves the accuracy of the original model on DVS-Gesture by more than 16%.Besides,in order to better incorporate the attention mechanism inside Transformer and the spatio-temporal information inherent to SNN,we adopt spatio-temporal attention (STA) instead of spatial-wise or temporal-wise attention.With our proposed method,we achieve competitive or state-of-the-art (SOTA) SNN performance on DVS-CIFAR10,DVS-Gesture,and ImageNet datasets with the least simulation time steps (i.e.low latency).Remarkably,our Spikeformer outperforms other SNNs on ImageNet by a large margin (i.e.more than 5%) and even outperforms its ANN counterpart by 3.1% and 2.2% on DVS-Gesture and ImageNet respectively,indicating that Spikeformer is a promising architecture for training large-scale SNNs and may be more suitable for SNNs compared to CNN.We believe that this work shall keep the development of SNNs in step with ANNs as much as possible.Code will be available

Parental Labor Migration and Time Use of Children Left Behind in Rural China

This study examines the relationship between parental migration and children’s time use within the setting of rural China. Through drawing on two large survey datasets and distinguishing between various forms of migration (father-only migration, mother-only migration, and the migration of both parents), I find that having a migrant parent is associated with more domestic work time among left-behind children, particularly for teenage girls with migrant mothers. When mothers are absent, adolescent daughters tend to step into a parenting role, take on additional domestic responsibilities and household tasks that are normally performed by the mothers. As a result, the gender gap in domestic labor increases and the traditional gendered division of labor becomes reinforced among left-behind children. Overall, this paper sheds light on the gendered implications of parental migration, especially maternal migration.Master of Art

A semi-analytical model for estimating total suspended matter in highly turbid waters

Total suspended matter (TSM) is related to water quality. High TSM concentrations limit underwater light availability, thus affecting the primary productivity of aquatic ecosystems. Accurate estimation of TSM concentrations in various waters with remote sensing technology is particularly challenging, as the concentrations and optical properties vary greatly among different waters. In this research, a semi-analytical model was established for Hangzhou Bay and Lake Taihu for estimating TSM concentration. The model construction proceeded in two steps. 1) Two indices of the model were calculated by deriving absorption and backscattering coefficients of suspended matter (ap(λ) and bbp(λ)) from the reflectance signal using a semi-analytical method. 2) The two indices were then weighted to derive TSM. The performance of the proposed model was tested using in situ reflectance and Geostationary Ocean Color Imager (GOCI) data. The derived TSM based on in situ reflectance and GOCI images both corresponded well with the in situ TSM with low mean relative error (32%, 41%), root mean square error (20.1 mg/L, 43.1 mg/L), and normalized root mean square error (33%, 55%). The model was further used for the slightly turbid Xin’anjiang Reservoir to demonstrate its applicability to derive ap(λ) and bbp(λ) in other water types. The results indicated that the form Rrs −1(λ1) − Rrs −1(λ2) could minimize the effect of CDOM absorption in deriving ap(λ) from the total absorption. The model exploited the different relationships between TSM concentration and multiband reflectance, thus improving the performance and application range in deriving TSM

Cost-effectiveness analysis of atezolizumab in patients with non-small-cell lung cancer ineligible for treatment with a platinum-containing regimen: a United Kingdom health care perspective

BackgroundCost-effectiveness of atezolizumab, as a treatment for advanced non-small-cell lung cancer (NSCLC) patients who cannot receive a platinum-containing regimen,was still unknown. Our objective was to evaluate the cost-effectiveness of atezolizumab vs. chemotherapy in this indication from the perspective of UK healthcare system.MethodsFrom the global, randomised, open-label, phase III IPSOS trial, clinical inputs and patient characteristics were obtained. A partitioned survival model with three health states was built: Progression-free survival, progressed disease and death. A lifetime time horizon was applied, with an annual discount rate of 3.5%. Additionally, the willingness-to-pay threshold of £50,000/QALY was utilized. Primary outcomes were quality-adjusted life-year (QALY), costs, and incremental cost-effectiveness ratio (ICER). Sensitivity, scenario, and subgroup analyses were used to assess the reliability of base-case results. Price simulations were carried out in order to provide information for the pricing strategy at specific willingness-to-pay threshold.ResultsIn the base-case analysis, atezolizumab resulted in a gain of 0.28 QALYs and an ICER of £94,873/QALY compared to chemotherapy, demonstrating no cost-effectiveness. Price simulation results revealed that atezolizumab would be preferred at a price lower than £2,215 (a reduction of 41.8%) at the willingness-to-pay threshold of £50,000. Sensitivity, scenario and subgroup analyses revealed these conclusions were generally robust, the model was most sensitive to the price of atezolizumab and subsequent medication. Furthermore, atezolizumab was found to be more cost-effective for patients displaying a positive PD-L1 expression, with an ICER of £72,098/QALY as compared to chemotherapy.ConclusionAtezolizumab is not cost-effective for patients with advanced NSCLC ineligible for platinum-containing regimen, potential price reduction is necessary

Phylogenetic, Expression, and Bioinformatic Analysis of the ABC1

We studied 17 ABC1 genes in Populus trichocarpa, all of which contained an ABC1 domain consisting of about 120 amino acid residues. Most of the ABC1 gene products were located in the mitochondria or chloroplasts. All had a conserved VAVK-like motif and a DFG motif. Phylogenetic analysis grouped the genes into three subgroups. In addition, the chromosomal locations of the genes on the 19 Populus chromosomes were determined. Gene structure was studied through exon/intron organization and the MEME motif finder, while heatmap was used to study the expression diversity using EST libraries. According to the heatmap, PtrABC1P14 was highlighted because of the high expression in tension wood which related to secondary cell wall formation and cellulose synthesis, thus making a contribution to follow-up experiment in wood formation. Promoter cis-element analysis indicated that almost all of the ABC1 genes contained one or two cis-elements related to ABA signal transduction pathway and drought stress. Quantitative real-time PCR was carried out to evaluate the expression of all of the genes under abiotic stress conditions (ABA, CdCl2, high temperature, high salinity, and drought); the results showed that some of the genes were affected by these stresses and confirmed the results of promoter cis-element analysis

PromptStyle: Controllable Style Transfer for Text-to-Speech with Natural Language Descriptions

Style transfer TTS has shown impressive performance in recent years. However, style control is often restricted to systems built on expressive speech recordings with discrete style categories. In practical situations, users may be interested in transferring style by typing text descriptions of desired styles, without the reference speech in the target style. The text-guided content generation techniques have drawn wide attention recently. In this work, we explore the possibility of controllable style transfer with natural language descriptions. To this end, we propose PromptStyle, a text prompt-guided cross-speaker style transfer system. Specifically, PromptStyle consists of an improved VITS and a cross-modal style encoder. The cross-modal style encoder constructs a shared space of stylistic and semantic representation through a two-stage training process. Experiments show that PromptStyle can achieve proper style transfer with text prompts while maintaining relatively high stability and speaker similarity. Audio samples are available in our demo page

htof::A New Open-source Tool for Analyzing Hipparcos, Gaia, and Future Astrometric Missions

We present htof, an open-source tool for interpreting and fitting the intermediate astrometric data (IAD) from both the 1997 and 2007 reductions of Hipparcos, the scanning-law of Gaia, and future missions such as the Nancy Grace Roman Space Telescope (NGRST). htof solves for the astrometric parameters of any system for any arbitrary combination of absolute astrometric missions. In preparation for later Gaia data releases, htof supports arbitrarily high-order astrometric solutions (e.g. five-, seven-, nine-parameter fits). Using htof, we find that the IAD of 6617 sources in Hipparcos 2007 might have been affected by a data corruption issue. htof integrates an ad-hoc correction that reconciles the IAD of these sources with their published catalog solutions. We developed htof to study masses and orbital parameters of sub-stellar companions, and we outline its implementation in one orbit fitting code (orvara, https://github.com/t-brandt/orvara). We use htof to predict a range of hypothetical additional planets in the $\beta$~Pic system, which could be detected by coupling NGRST astrometry with Gaia and Hipparcos. htof is pip installable and available at https://github.com/gmbrandt/htof .Comment: Accepted to AJ. References updated in version 2. The Hipparcos 2007 Re-reduction Java Tool Intermediate Astrometric Data are available at , via the "zip file" link at https://www.cosmos.esa.int/web/hipparcos/hipparcos-2 : "...human readable version of the IAD of the Java tool in a zip file [warning: ~350 MB]...

Isolation, characterization, and genomic analysis of a novel bacteriophage MA9V-1 infecting Chryseobacterium indologenes: a pathogen of Panax notoginseng root rot

Chryseobacterium indologenes is one of the primary causative agents of root rot of Panax notoginseng, which significantly affected plant growth and caused economic losses. With the increasing incidence of antibiotic-resistant bacterial phytopathogens, phage therapy has been garnered renewed attention in treating pathogenic bacteria. However, the therapeutic potential of phage therapy on root rot of P. notoginseng has not been evaluated. In this study, we isolated a novel lytic phage MA9V-1 infecting C. indologenes MA9 from sewage and monitored the formation of clear and round plaques with a diameter of approximately 0.5–1.5 mm. Phage MA9V-1 exhibited rapid absorption (>75% in 8 min), a latency period of 20 min, and a burst size of 10 particles per cell. Transmission electron microscopy indicated that the phage MA9V-1 is a new myovirus hosting C. indologenes MA9. Sequencing of phage genomes revealed that phage MA9V-1 contained a linear double-stranded DNA genome of 213,507 bp with 263 predicted open reading frames, including phage structure, host lysing, and DNA polymerase/helicase but no genes of tRNA, virulence, and antibiotic resistance. Our proteomic tree and genomic analysis revealed that phage MA9V-1 shares identity with Sphingomonas phage PAU and Tenacibaculum phage PTm1; however, they also showed apparent differences. Further systemic evaluation using phage therapy experiments on P. notoginseng suggested that phage MA9V-1 can be a potential candidate for effectively controlling C. indologenes MA9 infection. Thus, we have presented a novel approach to solving root rot in P. notoginseng

orvara::An Efficient Code to Fit Orbits using Radial Velocity, Absolute, and/or Relative Astrometry

We present an open-source Python package, Orbits from Radial Velocity, Absolute, and/or Relative Astrometry (orvara), to fit Keplerian orbits to any combination of radial velocity, relative astrometry, and absolute astrometry data from the Hipparcos-Gaia Catalog of Accelerations. By combining these three data types, one can measure precise masses and sometimes orbital parameters even when the observations cover a small fraction of an orbit. orvara achieves its computational performance with an eccentric anomaly solver five to ten times faster than commonly used approaches, low-level memory management to avoid python overheads, and by analytically marginalizing out parallax, barycenter proper motion, and the instrument-specific radial velocity zero points. Through its integration with the Hipparcos and Gaia intermediate astrometry package htof, orvara can properly account for the epoch astrometry measurements of Hipparcos and the measurement times and scan angles of individual Gaia epochs. We configure orvara with modifiable .ini configuration files tailored to any specific stellar or planetary system. We demonstrate orvara with a case study application to a recently discovered white dwarf/main sequence (WD/MS) system, HD 159062. By adding absolute astrometry to literature RV and relative astrometry data, our comprehensive MCMC analysis improves the precision of HD 159062B's mass by more than an order of magnitude to $0.6083^{+0.0083}_{-0.0073}\,M_\odot$. We also derive a low eccentricity and large semimajor axis, establishing HD 159062AB as a system that did not experience Roche lobe overflow.Comment: 24 pages, 5 figures, 5 tables. AJ accepted with minor changes. orvara is available at https://github.com/t-brandt/orvar

Precise Masses and Orbits for Nine Radial Velocity Exoplanets

Radial velocity (RV) surveys have discovered hundreds of exoplanetary systems but suffer from a fundamental degeneracy between planet mass $M_p$ and orbital inclination $i$. In this paper we break this degeneracy by combining RVs with complementary absolute astrometry taken from the Gaia EDR3 version of the cross-calibrated Hipparcos-Gaia Catalog of Accelerations (HGCA). We use the Markov Chain Monte Carlo orbit code $\tt orvara$ to simultaneously fit literature RVs and absolute astrometry from the HGCA. We constrain the orbits, masses, and inclinations of nine single and massive RV companions orbiting nearby G and K stars. We confirm the planetary nature of six companions: HD 29021 b ($4.47_{-0.65}^{+0.67}\,M_{\rm Jup}$), HD 81040 b ($7.24_{-0.37}^{+1.0}\,M_{\rm Jup}$), HD 87883 b ($6.31_{-0.32}^{+0.31}\,M_{\rm Jup}$), HD 98649 b ($9.7_{-1.9}^{+2.3}\,M_{\rm Jup}$), HD 106252 b ($10.00_{-0.73}^{+0.78}\,M_{\rm Jup}$), and HD 171238 b ($8.8_{-1.3}^{+3.6}\,M_{\rm Jup}$). We place one companion, HD 196067 b ($12.5_{-1.8}^{+2.5}\,M_{\rm Jup}$) on the planet-brown dwarf boundary, and two companions in the low mass brown dwarf regime: HD 106515 Ab ($18.9_{-1.4}^{+1.5}\,M_{\rm Jup}$), and HD 221420 b (${20.6}_{-1.6}^{+2.0}\,M_{\rm Jup}$). The brown dwarf HD 221420 b, with a semi-major axis of ${9.99}_{-0.70}^{+0.74}$ AU, a period of ${27.7}_{-2.5}^{+3.0}$ years, and an eccentricity of $0.162_{-0.030}^{+0.035}$ represents a promising target for high-contrast imaging. The RV orbits of HD 87883 b, HD 98649 b, HD 171238 b, and HD 196067 b are not fully constrained yet because of insufficient RV data. We find two possible inclinations for each of these orbits due to difficulty in separating prograde from retrograde orbits, but we expect this will change decisively with future Gaia data releases