Pemberian Ekstrak Batang Pohon Pisang Ambon (Musa paradisiaca var. sapientum) Untuk Mempercepat Proses Hemostasis Pada Mencit(Mus muscullus)

Background: In dentistry, tooth extraction sometimes cause postoperative and perioperative comp lications especially in patients with bleeding disorder. Uncontrolled bleeding during tooth extraction may cause some effects such as hypovolemic shock, difficulty of wound healing and it become sa port de entre of pathogenic bacteria that couldlead to an infection. The using of local and systemic haemostatic may cause some side effects for the patients such as alveolar bone necrosis in the socket. Herb plants that can be used to accelerate bleedings, in the population of Trunyans, Bali, is the hump ofbanana ambon. Musa paradisiaca var. sapientumhumpcontains several active compounds such as tannin and lectin. Tanin serve s to incrase the secretion of ADP in the process of platelet agrregration whereas lectin can incrase secretion of von Wilebrand Factor (vWF) in the process of platelet adhesion on the injury vessels. Purpose: To know the influence of granting Musa paradisiaca var. sapientumhump extract in concentration of 25%, 50% and 100% againts haemostatic response on mice. Methods: A whole research sample divided into four groups. Group 1 is control, group of 2 was given 25% extract concentration, group of 3 w as given 50% extract concentration and group of 4 w as given 100% extract concentration of Musa paradisiaca var. sapientum humps. Then all the groups were examined their bleeding time and clotting time. Results: A group with 100% extract of Musa paradisiaca var. sapientum hump having the shortest bleeding time and clotting time. Conclusion: Musa paradisiaca var. sapientum hump extract with concentration of 25%, 50% and 100% could shortening bleeding and clotting time on mice

The Bleeding And Clotting Time Analysis Of The Stem Extract Of Musa Paradisiaca Var. Sapientum (L.) Kunze On Hemostatic Response

A herbal medicine that can be used to accelerate bleeding is the Ambonese banana stem sap (Musa paradisiaca var. Sapientum) through secretion of Adenosin Diphosphate (ADP) and von Willebrand Factor (vWF) in the process of platelet adhesion on the injury vessels. The aim of this study to test the influence of Ambonese banana stem extract in a concentration of 25%, 50% and 100% against hemostatic response on mice. 24 animal study were randomly assigned into four groups. Group 1 was the control, group of 2 was given 25% extract concentration, group of 3 was given 50% extract concentration and group of 4 was given 100% extract concentration of Ambonese banana stem per-oral. Then all the groups were examined their bleeding and clotting time. The administration of Ambonese banana stem extract at the concentrations of 25%, 50 %, and 100% significantly shortened both bleeding time and clotting time compared to control group (p = 0.00). The group with 100% extract of the Ambonese banana stem having the shortest bleeding time and clotting time. The conclusions of this study showed Ambonese banana stem extract has potential as the hemostatic agent by shortening bleeding and clotting time on mice