Recomposing of Industrial Supply Chain and Constructing of Digital CBD

Drawing lessons from the development of cities at home and abroad success and lost experience, through practice research, this paper systemically analysis the evolution of urban economy space. In the scope of global industrial supply chain’s recomposing, it is discusses that modern city’s function structure characteristic, focusing “integrative logistics management service”. According to Dalian’s geography and resource advantage in district industry supply chain, this paper also proposes the digital CBD planning of Dalian which focuses integrative logistics management service

From Control to Competition: Trust Institution in E-Business

Global economy has formed a huge challenge to the trust of traditional business. It’s a important problem of all enterprise how to build a effective trust institution in the new economy. The rapid development of E-business is bringing a turning point of trust institution. In traditional trust institution, trust means that principal controls the agent in fact. The evolution of trust institution was closely related to the development of technology because of control. This paper presents, with the innovation of technology and system, precondition of trust through the method of controlling has already been out of the existence. The development of E-business will have influence on the evolution of trust institution, Advantages of E-business can promote monitor from man-made to market-made, from control to competition. It will build an effectual trust institution

Taking Advantage of E-Logistics to Strengthen the Competitive Advantage of Enterprises in China

With the fast development of the global economy, how to deliver the right products to the end-users in the demanding time and places becomes more and more important to the enterprises. In order to improve the competitive advantages, Chinese enterprises, especially the large manufacturers, need to develop e-logistics function and modern supply chain management systems. This paper describes the changing environment, such as competition, global trends, and logistics operations. Then the e-logistics is discussed, and it presents that the Descartes can improve the level of the information sharing and creates a new source of advantage to ensure competitiveness in today’s dynamic manufacturing marketplace. At last some suggestions are given, including establishing an integrated network, selecting the right industries, and so on

β2- but not β1-adrenoceptor activation modulates intracellular oxygen availability

β-Adrenoceptors (β-ARs) play a critical role in the regulation of cardiovascular function. Intracellular oxygen homeostasis is crucial for the survival of cardiomyocytes. However, it is still unclear whether β-AR activation can modulate intracellular oxygen. Here we used mitochondrial and cytosolic target Renilla luciferase to detect intracellular oxygen concentration. Pharmacological experiments revealed that β2-AR activation specifically regulates intracellular oxygen in cardiomyocytes and COS7 cells. This effect was abrogated by inhibitory G protein (Gi) inhibition, endothelial nitric oxide synthase (eNOS) blockade, and NO scavenging, implicating that the β2-AR–Gi–eNOS pathway is involved in this regulation. β2-AR activation increased the AMP/ATP ratio, AMPK activity, ROS production and prolyl hydroxylase activity. These effects also contribute to the regulation of β2-AR signalling, thus providing an additional layer of complexity to enforce the specificity of β1-AR and β2-AR signalling. Collectively, the study provides novel insight into the modulation of oxygen homeostasis, broadens the scope of β2-AR function, and may have crucial implications for β2-AR signalling regulation